Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands

Oohashi, Makoto; Toshima, Hiroo; Hayama, Koremasa; Ogura, Ichiro

doi:10.5114/pjr.2020.95458

Cited by 10 publications

(10 citation statements)

References 17 publications

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“…It has been reported that the scintigraphy is useful for detecting oral and maxillofacial lesions 6–14 . Recently, SPECT/CT has been applied for the evaluation of oral and maxillofacial lesions 15–22 . However, to our knowledge, few reports have been published on SUV of normal structures in the head and neck with bone SPECT/CT.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14] Recently, SPECT/CT has been applied for the evaluation of oral and maxillofacial lesions. [15][16][17][18][19][20][21][22] However, to our knowledge, few reports have been published on SUV of normal structures in the head and neck with bone SPECT/CT. The aim of this study is to evaluate maximum SUV of normal structures in the head and neck with bone SPECT/CT.…”

Section: Introductionmentioning

confidence: 99%

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Maximum standardized uptake value of normal structures in the head and neck with bone SPECT/CT

Tezuka

Ogura

2022

J Med Imag Rad Onc

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Introduction:The quantitative parameter was successfully derived from the quantitative bone SPECT/CT images. The aim of this study was to evaluate maximum standardized uptake value (SUV) of normal structures in the head and neck with bone SPECT/CT. Methods: Fifty-three patients with jaw lesions (11 chronic osteomyelitis, eight osteoradionecrosis and 34 medication-related osteonecrosis of the jaw) who had bone SPECT/CT were prospectively included. The maximum SUV of normal structures including vertebrae, sternal body, parietal bone and hyoid bone were analysed. Statistical analyses for the maximum SUV were performed by Pearson's rank correlation test. A P value lower than 0.05 was considered statistically significant. Results: The maximum SUVs of vertebrae, sternal body, parietal bone and hyoid bone of all patients were 8.10 AE 3.72, 5.16 AE 2.05, 3.67 AE 1.55 and 1.44 AE 0.56, respectively. Furthermore, the maximum SUV of vertebrae was significantly correlated with that of sternal body (Y = 0.527X + 5.388 (R 2 = 0.084, P = 0.035)). Conclusions: Maximum SUV with bone SPECT/CT should be useful for characterization of normal structures in the head and neck. Furthermore, the data reported herein can be used for reference in future studies and in clinical settings for head and neck lesions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maximum standardized uptake value of normal structures in the head and neck with bone SPECT/CT

Tezuka

Ogura

2022

J Med Imag Rad Onc

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“…Quantitative SPECT/CT offers the possibility to continue and expand the potential of quantitative nuclear medicine applications [9,10]. Quantitative salivary gland SPECT/CT holds promise as an objective imaging modality for assessment of salivary dysfunction [11][12][13]. Furthermore, SUV using Q.Metrix [14,15] and GI-BONE [16][17][18][19] software could be useful for the evaluation of jaw lesions.…”

Section: Introductionmentioning

confidence: 99%

Volumetric analysis of mandibular lesions with SPECT/CT: a pilot clinical study of maximum standardized uptake value

Minami¹,

Ogawa²,

Ogura³

2022

Pol J Radiol

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Purpose This study was designed to investigate mandibular lesions using volumetric analysis with bone single-photon emission computed tomography/computed tomography (SPECT/CT). Material and methods Eight patients with mandibular lesions underwent SPECT/CT scan acquisition 4 hours after injection of Tc-99m hydroxymethylene diphosphonate (HMDP). Regarding volumetric analysis, maximum standar-dized uptake value (SUV) was obtained using software and a workstation (Q.Volumetrix MI and GEniE-Xeleris 4 DR, respectively). The localization and size of the volume of interest (VOI) can be drawn over the lesion, mesial, distal, and opposite side as normal using the CT, SPECT, and SPECT/CT transaxials, coronals, and sagittals as the anatomical reference. Q.Volumetrix MI can analyse SUV of lesions by organ segmentation using optional pan and zoom imaging. Then, the dosimetry software provided multiple quantitative data for a given VOI. Statistical analyses for the maximum SUV were performed by Mann-Whitney U test. A p -value lower than 0.05 was considered as statistically significant. Results Maximum SUVs for medication-related osteonecrosis of the jaw ( n = 4, 25.4 ± 4.9), chronic osteomyelitis ( n = 3, 14.6 ± 3.1), and squamous cell carcinoma ( n = 1, 31.7) were significantly higher than those of the opposite side as normal mandible (3.8 ± 0.7, 4.6 ± 1.8, and 7.4, respectively; p = 0.000). Conclusions Volumetric analysis with SPECT/CT could be useful for the evaluation of mandibular lesions, such as detecting and surgical planning.

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“…Recently, single photon emission computed tomography (SPECT)/CT has been found to be useful for the evaluation of oral and maxillofacial lesions 17‐22 . Investigating salivary gland dysfunction with SPECT/CT may be a useful tool for evaluating salivary gland dysfunction 23,24 .…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11][12][13][14][15][16] Recently, single photon emission computed tomography (SPECT)/ CT has been found to be useful for the evaluation of oral and maxillofacial lesions. [17][18][19][20][21][22] Investigating salivary gland dysfunction with SPECT/CT may be a useful tool for evaluating salivary gland dysfunction. 23,24 Furthermore, time-activity curves (TAC) using SPECT/CT may also be useful for evaluating salivary gland dysfunction.…”

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A clinical pilot study of salivary gland secretion for xerostomia patients with Sjögren’s syndrome using SPECT/CT

Minami

Ogura

2021

Gerodontology

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Introduction This study examined whether time‐activity curves (TAC) can be used to differentiate between patients with and without Sjögren's syndrome using SPECT/CT. Methods Thirteen xerostomia patients (5 with Sjögren's syndrome and 8 without Sjögren's syndrome) underwent SPECT/CT. Salivary gland secretion data were digitally observed, producing separate time‐activity curves (TAC) for the submandibular glands and parotid glands using SPECT/CT. The salivary gland secretion fraction was defined as A (before stimulation test [counts/frame]) divided by B (after stimulation test [counts/frame]). The A/B ratios of patients with Sjögren's syndrome and those without Sjögren's syndrome were compared using the Mann‐Whitney U test for nonparametric data. Results The A/B ratio of parotid glands with Sjögren's syndrome (1.3 ± 0.2) was significantly lower than for those without Sjögren's syndrome (2.7 ± 0.7). The A/B ratio of submandibular glands with Sjögren's syndrome (1.3 ± 0.4) is significantly lower than for those without Sjögren's syndrome (1.8 ± 0.6). Conclusion The TAC for the submandibular glands and parotid glands using SPECT/CT may be useful for the objective and quantitative diagnosis of Sjögren's syndrome.

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Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands

Cited by 10 publications

References 17 publications

Maximum standardized uptake value of normal structures in the head and neck with bone SPECT/CT

Maximum standardized uptake value of normal structures in the head and neck with bone SPECT/CT

Volumetric analysis of mandibular lesions with SPECT/CT: a pilot clinical study of maximum standardized uptake value

A clinical pilot study of salivary gland secretion for xerostomia patients with Sjögren’s syndrome using SPECT/CT

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