Gallstones are associated with carotid atherosclerosis

Méndez-Sánchez, Nahúm; Zamora-Valdés, Daniel; Flores-Rangel, José A.; Pérez-Sosa, Julio A; Vásquez-Fernández, Francisco; Lezama-Mora, Jezer; Vázquez-Elizondo, Genaro; Ponciano-Rodríguez, Guadalupe; Ramos, Martha H.; Uribe, Misael

doi:10.1111/j.1478-3231.2007.01632.x

Cited by 27 publications

(16 citation statements)

References 21 publications

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“…Significant associations between gallstone disease and CHD risk were also observed in cross-sectional studies, 19, 20 and other prospective cohort studies in Asian 21, 22 and German 17 populations. The most recent and largest prospective study so far emerged from the China Kadoorie Biobank study, 22 which involved 199,292 men and 288,081 women, followed for a median 7.2 years.…”

Section: Discussionsupporting

confidence: 54%

Gallstones and Risk of Coronary Heart Disease

Zheng

et al. 2016

ATVB

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Objective Gallstone disease has been related to cardiovascular risk factors; however, whether presence of gallstones predicts coronary heart disease (CHD) is not well established. Approach and Results We followed 269,142 participants who were free of cancer and cardiovascular disease at baseline from 3 U.S. cohorts: the Nurses’ Health Study (NHS; 112,520 women; 1980–2010), NHS II (112,919 women; 1989–2011) and the Health Professionals Follow-up Study (HPFS; 43,703 men; 1986–2010), and documented 21,265 incident CHD cases. After adjustment for potential confounders, the hazard ratio for the participants with a history of gallstone disease compared with those without was 1.15 (95% confidence interval [CI] 1.10–1.21) in NHS, 1.33 (1.17–1.51) in NHS II, and 1.11 (1.04–1.20) in HPFS. The associations appeared to be stronger in individuals who were not obese, not diabetic, or were normotensive, compared to their counterparts. We identified 4 published prospective studies by searching PUBMED and EMBASE up to October 2015, coupled with our 3 cohorts, involving 842,553 participants and 51,123 incident CHD cases. The results from meta-analysis revealed a history of gallstone disease was associated with a 23% (15–33%) increased CHD risk. Conclusions Our findings support that a history of gallstone disease is associated with increased CHD risk, independently of traditional risk factors.

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Section: Discussionsupporting

confidence: 54%

Gallstones and Risk of Coronary Heart Disease

Zheng

et al. 2016

ATVB

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“…In those studies, patients were not limited to CAD. More recently, two studies reported that cardiovascular disease, defined by ultrasonographic measurements of carotid artery intima-media thickness [13], and coronary heart disease, defined as myocardial ischemia using the excise treadmill test based on the Bruce protocol [20], were associated with gallstone disease. These diagnostic criteria, however, have several limitations.…”

Section: Discussionmentioning

confidence: 99%

“…Gallstone disease was confirmed by B-type ultrasonography, using the same criteria as reported [13]. Patients with previous cholecystectomies were not included because of uncertainty whether their indications for surgery were gallstone disease or other gallbladder diseases.…”

Section: Methodsmentioning

confidence: 99%

Gallbladder Gallstone Disease Is Associated with Newly Diagnosed Coronary Artery Atherosclerotic Disease: A Cross-Sectional Study

Jiang

Sheng

et al. 2013

PLoS ONE

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Background and AimsThe association between gallstone disease and coronary artery atherosclerotic disease (CAD) remains unclear. To clarify their relationship, patients with CAD newly diagnosed by coronary angiography were investigated in this cross-sectional study.MethodsThe study cohort consisted of 1,270 patients undergoing coronary angiography for the first time between January 2007 and September 2011. Patients with ≥50% diameter stenosis in any major coronary artery on coronary angiography were defined as being CAD positive (n = 766) and those with no stenosis as CAD negative (n = 504). Multivariate logistic regression was used to investigate the relationship between gallstone disease and CAD. The odds ratios (OR) of factors associated with CAD were calculated. In addition, CAD-positive and CAD-negative patients were matched one-to-one by age, gender and metabolic syndrome (MetS), and the association between gallbladder disease and CAD was determined.ResultsThe prevalence of gallstone disease was significantly higher in CAD-positive than in CAD negative patients (149/766 [19.5%] vs 57/504 [11.3%], P<0.01). Gallstone disease was significantly associated with CAD (adjusted OR = 1.59, 95% confidence interval [CI] 1.10–2.31). Following matched pairing of 320 patients per group, gallstone disease remained significantly associated with CAD (adjusted OR = 1.69, 95% CI: 1.08–2.65).ConclusionGallstone disease is strongly associated with CAD diagnosed by coronary angiography.

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“…Recently Mendez-Sanchez et al26) reported that carotid IMT increased in gallstone patients and a 0.1 mm increase in carotid IMT increased the prevalence of gallstone disease by 1.25 times (95% CI, 1.02 to 1.53; P = 0.027). Also Mendez-Sanchez et al27) reported that patients with coronary artery disease were at higher risk for gallstone disease (odds ratio, 2.84), and Chavez-Tapia et al28) reported that patients undergoing cholecystectomy were at greater risk for cardiovascular disease.…”

Section: Discussionmentioning

confidence: 96%

Gallstones are Associated with Intima-Media Thickness of Common Carotid Arteries in Men

et al. 2014

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BackgroundThe prevalence of gallstone disease is increasing in Korea. Gallstone disease and atherosclerosis share common risk factors. Ultrasonographic carotid intima-media thickness is an independent predictor of atherosclerosis. We measured the carotid intima-media thickness among men who had gallstones to establish the association between atherosclerosis and gallstones.MethodsA total of 330 men who visited the health promotion center of the IS Hallym Hospital from January 2011 to July 2012 were recruited. Both abdomen and carotid ultrasonographies were performed. Demographic, anthropometric, and biochemical data were collected.ResultsThe prevalence of gallstones was 6.6%. The carotid intima-media thickness, age, and body mass index were higher in subjects with gallstones (P < 0.05 for all). After Pearson correlation analysis, gallstone, age, body mass index, and fasting blood sugar were significantly associated with carotid intima-media thickness. A statistically positive association between gallstone and carotid intima-media thickness was demonstrated in a multivariate analysis adjusted for age, body mass index, and fasting blood sugar.ConclusionCarotid intima-media thickness is higher in male subjects with gallstones, indicating that they are at greater risk for atherosclerosis.

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Gallstones are associated with carotid atherosclerosis

Abstract: Subjects with GD exhibit greater carotid atherosclerosis, and therefore have a higher risk for stroke and myocardial infarction.

Cited by 27 publications

References 21 publications

Gallstones and Risk of Coronary Heart Disease

Gallstones and Risk of Coronary Heart Disease

Gallbladder Gallstone Disease Is Associated with Newly Diagnosed Coronary Artery Atherosclerotic Disease: A Cross-Sectional Study

Gallstones are Associated with Intima-Media Thickness of Common Carotid Arteries in Men

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