Gambaran Histopatologi Hati Tikus Wistar Yang Diberikan Boraks

Tatukude, Rico Lukas; Loho, Lily; Lintong, Poppy M.

doi:10.35790/ebm.2.3.2014.6209

Cited by 4 publications

(5 citation statements)

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“…Terminasi Hewan Percobaan (Tatukude et al, 2014) Hewan percobaan diterminasi setelah penelitian berakhir dengan pemberian anastesi memakai kapas yang ditetesi eter. Tikus dan kapas yang telah ditetesi eter dimasukkan kedalam toples kemudian ditutup.…”

Section: Funclassified

POTENSI EKSTRAK ETIL ASETAT Coprinus comatus TERHADAP KADAR UREUM DAN KREATININ PADA TIKUS PUTIH MODEL DIABETES

Perdanawati

Ratnaningtyas

Hernayanti

2022

bioe

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Coprinus comatus atau jamur paha ayam berpotensi sebagai antioksidan dan antidiabetes. Kondisi hiperglikemia pada penderita diabetes mellitus menyebabkan peningkatan Reactive Oxygen Species (ROS). Sel β pankreas memiliki antioksidan hanya sedikit dibandingkan organ lain. Hal ini menyebabkan stress oksidatif yang memicu reaksi berantai peroksidasi lipid sehingga merusak organ ginjal dan laju filtrasi glomerulus terganggu. Laju filtrasi glomerulus yang terganggu ditandai dengan peningkatan kadar ureum dan kreatinin. Flavonoid yang terkandung dalam C. comatus mampu mendonorkan H+ dan menghentikan reaksi peroksidasi lipid pada ginjal sehingga kadar ureum dan kreatinin menurun.Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etil asetat C. comatus terhadap kadar ureum dan kreatinin darah tikus model diabetes dan untuk mengetahui dosis efektif ekstrak etil asetat C. comatus terhadap kadar ureum dan kreatinin darah tikus model diabetes. Penelitian ini menggunakan metode eksperimental yang disusun berdasarkan Rancangan Acak Lengkap (RAL). Data yang diperoleh dari hasil pengukuran kadar ureum dan kreatinin dianalisis menggunakan uji statistik one way Anova pada tingkat kepercayaan 95% dan dilanjutkan dengan uji Duncan pada tingkat kesalahan 5%. Hasil penelitian ini menunjukkan bahwa ekstrak etil asetat C. comatus berpengaruh terhadap kadar ureum dan kreatinin darah tikus model diabetes. Ekstrak C. comatus dosis 500 mg/kgBB merupakan dosis efektif yang berpengaruh terhadap penurunan kadar ureum dan kreatinin darah pada tikus model diabetes yaitu sebesar 16,66 ± 0,00 mg/dL dan 0,40 ± 0,12 mg/dL.

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Section: Funclassified

POTENSI EKSTRAK ETIL ASETAT Coprinus comatus TERHADAP KADAR UREUM DAN KREATININ PADA TIKUS PUTIH MODEL DIABETES

Perdanawati

Ratnaningtyas

Hernayanti

2022

bioe

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“…Microscopically visible, small clearcolored fat spots. Toxins inhibit lipid transfer from cells to the bloodstream, which results in fatty in hepar (Sherlock, 2004). From the results of hetopathology, rat liver damage was the highest in the negative control group, namely the opposing group.…”

Section: Analysis Of Liver Histopathologymentioning

confidence: 99%

A Hepatoprotective Effect of Extract Ethanol Gynura procumbens on Liver Injury Induced by Toxic Dose of Paracetamol

2022

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Gynura procumbens is a plant that contains flavonoid compounds as antioxidants and has a hepatoprotective effect. A hepatoprotector is a compound that can protect the liver from liver damage. One way to determine liver function is to measure the enzyme activity of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). This study aimed to determine the hepatoprotective effect of the extract ethanol of Gynura procumbens on the liver induced by paracetamol toxic dose. This study used 20 white male rats divided into five groups: positive control group, negative control (NaCMC 1%), and paracetamol dose of 2.400mg/kg bw). EDSNY 100 mg/kg bw, 200 mg/kg bw, 300 mg/kg bw + 2.400 mg/kg paracetamolThe rat blood samples were taken through the lateral vein, and then the SGOT and SGPT were measured before, after 4 days, and on the 6th day after paracetamol induction. The results showed that the ethanol extract of Gynura procumbens significantly reduced the levels of SGPT in mice at a dose of 300 mg/kg bw. However, the ethanol extract of Gynura procumbens leaves could not reduce SGOT levels in rats. From the histopathological results, it was evident that both low, medium, and high doses had not been able to significantly improve liver damage induced by toxic doses of paracetamol. However, the ethanol extract of Gynura procumbens leaves appeared to reduce the number of areas of necrosis and degeneration of hepatocytes compared to the negative control group. Based on the study's results, the ethanol extract of Gynura procumbens leaves at a dose of 300 mg/kg bw was able to protect against an increase in SGPT. Still, it hadn't shown that it was the best way to protect the liver from damage caused by too much paracetamol.

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“…Borax has harmful toxic effects. Borax acid was not allowed to enter the body because it could damage liver [17] and had the effect of carsinogenic [18], testis death [19]. At the stage of steaming, the potential physical contaminants could originate from the water used.…”

Section: Determination Of Critical Control Point (Ccp)mentioning

confidence: 99%

Boric Acid And Hazard Analysis Critical Control Point (HACCP) On Kerupuk To Improve The Indonesian`S Traditional Foods Safety

Moelyaningrum¹

2019

Preprint

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INTERNATIONAL JOURNAL OF SCIENTIFIC & TECHNOLOGY RESEARCH VOLUME 8, ISSUE 06, JUNE 2019 Abstract: Diseases can be caused by consumption of contaminated food such as toxicant. Kerupuk are one of the traditional foods produced by some of the traditional industries in Jember. The objective of this study was to identify the content of borix acid and analyze hazards and determine the critical control points on tofu crackers. This could raise the traditional food safety for consumers. This study was a descriptive study conducted by interview and observation. Boric acid testing was carried out on five samples of kerupuk. Instrument sheets referred to the SNI CAC RCP1-2011. The results indicated that 100% of the samples contained boric acid. The selection of materials, slicing, drying and distribution were the control points while mixing and kneading, steaming, frying and packaging were the critical control point. Boric acid is still used on tofu kerupuk; therefore, the government should immediately provide information and training on sustainable traditional food industry to reduce the incidence of illness and food poisoning in traditional food.

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Gambaran Histopatologi Hati Tikus Wistar Yang Diberikan Boraks

Cited by 4 publications

References 0 publications

POTENSI EKSTRAK ETIL ASETAT Coprinus comatus TERHADAP KADAR UREUM DAN KREATININ PADA TIKUS PUTIH MODEL DIABETES

POTENSI EKSTRAK ETIL ASETAT Coprinus comatus TERHADAP KADAR UREUM DAN KREATININ PADA TIKUS PUTIH MODEL DIABETES

A Hepatoprotective Effect of Extract Ethanol Gynura procumbens on Liver Injury Induced by Toxic Dose of Paracetamol

Boric Acid And Hazard Analysis Critical Control Point (HACCP) On Kerupuk To Improve The Indonesian`S Traditional Foods Safety

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