Gambaran Karakteristik Penderita Endometriosis di RSUP Prof. Dr. R. D. Kandou Manado

Wu, Indrani B.; Tendean, Hermie M. M.; Mewengkang, Maya

doi:10.35790/ecl.5.2.2017.18568

Cited by 5 publications

(7 citation statements)

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“…Factors that are at risk for endometriosis need to be carefully focused such as the linkage of activity factors associated with gadget addiction (21), drugs (22), and stressing factors caused by association such as bullying (23). Family as a support system must be the vanguard to detect this problem and provide information and take important steps if it happens (24).…”

Section: Discussionmentioning

confidence: 99%

Polymorphism for Interleukin-4 (-590 C/T) Promoter: Non-Association with Endometriosis

Hairunisyah

Fatimah

2022

CHIPROF

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Endometriosis is a benign gynecological disorder that often occurs in women of reproductive age, usually characterized by endometrial epithelium and stroma outside their usual location. It is estimated that this disease affects 56% of women worldwide. Various types of cytokines are associated with endometriosis, including interleukin IL-4, which inhibits the production of proinflammatory cytokines that stimulate active B cells and T cell proliferation, the differentiation of B cells into plasma cells. Il-4 promoter region polymorphism (-590C/T) is involved in genetic susceptibility to endometriosis. This study aims to determine whether Gen IL-4 (-590C/T) polymorphism indicates endometriosis. This study is an analytical observational study conducted at the Laboratory of Molecular Biology in Palembang City in August 2021, with the approach of Case-Control study. There were 70 samples divided into two groups, namely 35 cases and 35 controls. Determination of genotypes and alleles using PCR-RFLP and chi-square analyzed data to determine the relationship. The results showed no significant difference. The genomorphism of the Interleukin-4(-590C/T) gene cannot be used to indicate endometriosis susceptibility.

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Section: Discussionmentioning

confidence: 99%

Polymorphism for Interleukin-4 (-590 C/T) Promoter: Non-Association with Endometriosis

Hairunisyah

Fatimah

2022

CHIPROF

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“…Several theories tried to explain the pathophysiology behind endometriosis such as retrograde menstruation and implantation theory, lymphatic and vascular embolism, celomic, hormonal metaplasia, immunological and inflammatory dysfunction and genetic predisposition. 9 The most adapted theory is the retrograde menstruation theory proposed by Sampson in 1927. 11 Nowadays, inflammation theory is currently the most developed.…”

Section: Backgroundsmentioning

confidence: 99%

“…Currently, the Endometriosis Fertility Index (EFI) score is used as an indicator to predict pregnancy in patients undergoing surgery by combining patient history (historical factors) and intraoperative findings (surgical factors). [9][10][11][12][13] From the description above, the main problem in endometriosis is a chronic inflammatory process which involves several systemic and local inflammatory cytokines. Endometriotic lesions produce inflammatory cytokines, increasing their levels in the peritoneal fluid.…”

Section: Backgroundsmentioning

confidence: 99%

Correlation Between Levels of Interleukin-6 in Peritoneal Fluid With Degree of Pain, Adhesion, and Endometriosis Fertility Index Score in Endometriosis

Prima

Hendry

Bachtiar

2021

AOJ

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Introduction : Endometriosis is a benign gynecological disorder characterized by the presence of endometrial tissue and stroma outside the uterine cavity. Several theories have been proposed to explain the occurrence of endometriosis, one of which is the theory of inflammation. Endometriosis lesions can produce inflammatory cytokines, resulting in their increased levels in the peritoneal fluid. This process causes disruption in pelvic anatomy, ovarian function, prostaglandin production and growth factor production that causes pain, adhesions and infertility. Interleukin-6 (IL-6) is an important and potential inflammatory cytokine in assisting the diagnosis of endometriosis. These cytokines act as activating macrophages that can stimulate endometrial cell proliferation and modulate the secretion of other cytokines such as IL-10, IL-13 and TNF-α which augments the inflammatory process. High levels of IL-6 in the peritoneum are relatedto advanced endometriosis associated with pain, severe pelvic adhesions and embryotoxic effects leading to infertility. The effect of IL-6, both local and systemic, on the growth of endometriosis lesions and its associated symptoms is great that this cytokine is considered an important marker.Objective : This study aims to determine the relationship between local inflammatory factors (IL-6 in peritoneal fluid) obtained during laparoscopy with the degree of pain, the degree of adhesions and the correlation with the Endometriosis Fertility Index (EFI) score in endometriosis patients.Material and methods : This is a quantitative analytic research with a cross sectional study design which was conducted on 22 patients with endometriosis. Prior to the laparoscopy, historical factor (EFI score) was recorded and an assessment of the pain scale was performed by filling out a questionnaire. Intraoperatively, the peritoneal fluid was obtained. If the peritoneal fluid was found, it was taken directly with a volume of 3-5 cc using 10 cc syringe. If no fluid was found, peritoneal rinsing was performed using 0.9% NaCl fluid, then 3-5 cc fluid was aspirated using a 10 cc syringe. Subsequently, an examination was carried out using the RayBio Human IL-6 ELISA Kit. During the laparoscopy procedure, the degree of adhesion of the pelvic organs was assessed by looking at the shape and how the adhesions can be separated. Surgical factor (EFI score) was assessed intraoperatively to obtain data for the least function score, AFS endometriosis score and AFS total score. Statistical analysis was performed using paired t test and correlation test.Results : The mean age of the respondents was 34.86 ± 6.11 years, 81.8% were nulliparous, 100% were married, 100% experienced both primary and secondary infertility and 81.8% had no prior pregnancy history. In the study, it was found that IL-6 levels of peritoneal fluid were higher in patients with the degree of severe pain (P <0.05) compared to moderate with the results of 32.58 ± 7.31 pg/ml and 25.39 ± 2.70 pg/ml. IL-6 levels were found to be higher in grade three adhesions than grade two (P <0.05) with results of 32.78 ± 6.65 pg/ml and 23.86 ± 2.18 pg/ml. The mean peritoneal fluid IL-6 levels were 30.75 ± 7.01 pg/ml and the mean EFI score was 4.09 ± 2.09. The correlation of IL-6 levels in peritoneal fluid with EFI score showed a value of r = -0.448 which had moderate strength and a negative pattern, indicating that the higher the IL-6 level of peritoneal fluid, the lower the EFI score (P <0.05).Conclusion : There is a relationship between IL-6 levels of peritoneal fluid in endometriosis with the degree of pain and the degree of adhesion, where IL-6 levels were found to be higher in the degree of severe than moderate pain (P <0.05), higher in third degree adhesions than second degree ( P <0.05). There was a correlation between IL-6 levels of peritoneal fluid with EFI score (P <0.05) with a negative pattern of moderate strength analysis results (r = -0.448).Keywords: Endometriosis, Interleukin-6, Degree of Pain, Degree of Adhesion, Endometriosis Fertility Index Score

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“…Clinical manifestation of endometriosis includes dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, abnormal uterine bleeding, and infertility. Natural conception can only be achieved on 10-11% infertile endometriosis patients [2], [3].…”

Section: Introductionmentioning

confidence: 99%

“…Surgical treatment is an important therapy in endometriosis management which aims to remove endometriotic tissue and maintain the maximum amount of normal ovarian tissue [3]. Ovarian reserve (OR) was decreased in women with endometriosis compared to healthy women of the same age or women with benign ovarian cysts [4].…”

Section: Introductionmentioning

confidence: 99%

Surgical Techniques to Reduce the Diminished Ovarian Reserve Risk of Endometrial Cyst

Rusda

Adenin

Prabudi

et al. 2021

Open Access Maced J Med Sci

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AIM: The objective of the study was to report the endometriosis case and surgical technique to reduce the diminished ovarian reserve risk. CASE PRESENTATION: A 32-year-old woman was presented with the lower abdominal pain since 1 year ago, intermittent, and got worse during menstruation. The mobile cystic mass was palpable on the abdomen without pain during palpation. Vaginal examination showed mobile and smooth surface cystic mass was palpable, the upper pole was three fingers below the umbilicus, and lower pole was in line with pubic symphysis. Transvaginal ultrasonography (TVUS) showed uterus and right ovary enlargement; and unilocular cyst with homogenous echo pattern. There was a marked increase in CA-125. Based on International Tumor Analysis, the tumor was classified as B1 unilocular cyst and the malignancy risk index was 600. The patient was diagnosed with endometriosis and laparotomy cystectomy was performed. CONCLUSION: Patient was diagnosed with endometrial cyst and laparotomy cystectomy was performed as treatment. Ovarian cystectomy in infertile women was shown to have comparable ovarian reserve (OR), reduced pain symptoms, and increased conception among infertile patients.

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Gambaran Karakteristik Penderita Endometriosis di RSUP Prof. Dr. R. D. Kandou Manado

Cited by 5 publications

References 0 publications

Polymorphism for Interleukin-4 (-590 C/T) Promoter: Non-Association with Endometriosis

Polymorphism for Interleukin-4 (-590 C/T) Promoter: Non-Association with Endometriosis

Correlation Between Levels of Interleukin-6 in Peritoneal Fluid With Degree of Pain, Adhesion, and Endometriosis Fertility Index Score in Endometriosis

Surgical Techniques to Reduce the Diminished Ovarian Reserve Risk of Endometrial Cyst

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