Endometriosis adalah salah satu penyakit ginekologi jinak yang paling umum, penyakit ini dikaitkan dengan nyeri panggul dan subfertilitas pada sekitar 176 juta wanita diseluruh dunia. Keterlambatan pemeriksaan penyakit ini dapat terjadi selama bertahun-tahun karena diagnosis penyakit ini harus melalui laparoskopi. Penelitian ini dilakukan untuk mengetahui gambaran karakteristik endometriosis di RSUP Dr. M. Djamil Padang periode 2017-2019. Jenis penelitian ini adalah deskriptif dengan 98 orang penderita endometriosis di RSUP Dr. M. Djamil Padang pada tahun 2017- 2019 sebagai sampel penelitian. Instrumen dari penelitian ini adalah data rekam medik dan hasil wawancara dengan pasien. Kasus endometriosis paling banyak ditemukankan pada kelompok usia reproduktif (85,71%), nullipara (60,20%), kategori IMT berat badan normal (35,71%), lama infertilitas ≥ 5 tahun (27,55%), dengan keluhan utama berupa dismenorea (69,39%). Stadium penyakit yang paling banyak di temukan adalah stadium III-IV (82,65%), pada lokasi anatomis internal pelvis, mayoritas pasien diberikan terapi hormon selama 3 bulan setelah terapi (75,51%), merasakan perbaikan rasa nyeri (83,67%), tidak melakukan program kehamilan (92,86%), dan tidak mengalami kekambuhan setelah terapi (88,78%). Penelitian ini menyimpulkan bahwa kejadian endometriosis tinggi pada wanita usia reproduktif, pemberian edukasi mengenai endometriosis yang baik perlu dilakukan agar dapat mengurangi penundaan diagnosis penyakit ini sehingga bisa ditangani ketika stadium masih ringan.

There are changes of eutopic endometrium molecular fenotipe in endometriosis such as changes in gene expression, steroid hormone response, increase of inflammation marker and cellular adhesion molecule, decrease of apoptotic index and decidualization capacity, increase of oxidative stress marker, increase activity of angiogenesis and neurogenesis. This study was conducted to analyze the differences in the expression of angiogenic factors (VEGF A) and neurogenesis factors (PGP 9.5) eutopic endometrium of menstrual bleeding among patients with endometriosis and non endometriosis and then the correlation of the two factors. This study is a cross sectional that examines the relationship between the incidence of endometriosis with risk factors such as VEGF expression and PGP 9.5 in menstrual blood. There were significant differences in the expression of VEGF A eutopic endometrium menstrual blood between endometriosis and non endometriosis group (p=0.002). There are significant differences expression of VEGF A and PGP 9.5 eutopic endometrial of menstrual blood between endometriosis and non endometriosis groups. There is a positive correlation between the expression of VEGF A with PGP 9.5 eutopic endometrial of menstrual blood on endometriosis patients.Keywords: eutopic endometrium, menstrual blood, VEGF A expression, PGP 9.5 expression, immunocytochemistry

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Background : Endometriosis is a benign gynecological disorder characterized by the presence of endometrial glands and stroma outside the normal location. Endometriosis is a chronic disorder which is a major cause of infertility, dysmenorrhea, dyspareunia and chronic pelvic pain with varying degrees of pain. Management of endometriosis can be in the form of medical therapy and/ or surgical therapy. Surgical therapy can be conservative and definitive.Objective : This study aims to obtain the characteristics of patients with endometriosis and adenomiosis who are operated at Dr. M. Djamil Padang for the period of January 2017 - October 2018.Method : This was descriptive retrospective study, using medical records data of endometriosis patient at Dr. RSUP M. Djamil Padang.Result : The results of the study obtained 160 cases of endometriosis patients who were operated during that period but only 154 patients had complete data in the medical record. Endometriosis cases were common among age of 36-45 years old (42.2%), married (87.7%), nullipara (61.7%), ovarian endometrioma (44.8%),laparotomy method (54.6%), type of surgery was cystectomy (44.8%), and pain reduced post operation (62.7%).Conclusion : Most frequent characteristics of endometriosis patient were operated in the 36-45 year age group, married, nullipara, ovarian endometrioma, laparotomy method, type of surgery was cystectomy and pain reduced post operationKeywords: endometriosis, adenomiosis, dysmenorrhea

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