Gambaran Klinis dan Laboratoris Diabetes Mellitus tipe-1 pada Anak Saat Pertama Kali Datang ke Bagian IKA-RSCM Jakarta

Pulungan, Aman B; Mansyoer, Riza; Batubara, Jose Rl; Aap, Bambang Tridjaja

doi:10.14238/sp4.1.2002.26-30

Cited by 5 publications

(10 citation statements)

References 2 publications

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“…The most distribution of sex in the two research groups are female. This is in accordance with previous research in which the incidence of T1DM in Indonesia with male sex ratio compared to female 45 : 55, besides that female has proportion 3 times more than male [18]. But contrary to data from the IDF in 2011 that says that male more than female as much as 1.5 times.…”

Section: Subject Characteristicssupporting

confidence: 91%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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Section: Subject Characteristicssupporting

confidence: 91%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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“…Kekurangan insulin absolut ditemukan pasien penyakit DM tipe 1, hal ini disebabkan adanya kerusakan sel ß pankreas yang terus menerus, sehingga insulin tidak dapat dibuat oleh kelenjar tersebut. 1 Diagnosis DM tipe 1 ini ditetapkan berdasarkan patokan klinis dan laboratorik. Diagnosis ditetapkan bila ditemukan gejala klinis: poliuria, polidipsi dan polifagia; atau berat badan menurun yang umumnya diderita oleh anak dan remaja disertai tingkat glukosa darah sewaktu lebih dari 200 mg/dL atau kadar glukosa darah puasa 126 mg/dL dengan uji toleransi tingkat glukosa darah puasa > 140 mg/dL.…”

Section: Pembahasanunclassified

“…Diagnosis ditetapkan bila ditemukan gejala klinis: poliuria, polidipsi dan polifagia; atau berat badan menurun yang umumnya diderita oleh anak dan remaja disertai tingkat glukosa darah sewaktu lebih dari 200 mg/dL atau kadar glukosa darah puasa 126 mg/dL dengan uji toleransi tingkat glukosa darah puasa > 140 mg/dL. 1 Kasus ini ditemukan di seorang anak perempuan berusia 12 tahun. Hal ini sesuai dengan penggolongan penyakit DM menurut American Diabetes Association (ADA) bahwa pasien DM tipe 1 terutama yang ditemukan di kelompok anak-anak dan remaja.…”

Section: Pembahasanunclassified

“…Laporan kasus ini bertujuan untuk mengetahui adanya penyakit DM tipe 1 pada anak yang disertai dengan ketoasidosis diabetik. 1,4 Gejala klinis pasien DM tipe 1 yaitu poliuria, polidipsi dan polifagia; selain itu ada penurunan berat badan yang menerus serta peningkatan tingkat glukosa darah sewaktu >200 mg/dL. Tingkat gula darah akan meningkat dan mengakibatkan kenaikan osmolalitas cairan ekstrasel.…”

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“…Kekurangan insulin di pasien DM tipe 1 juga mengakibatkan pengambilan asam amino dan pembuatan protein berkurang, sehingga keperluan nitrogen otot dan masanya (otot) berkurang dan mengakibatkan penurunan berat badan. 1 Sel ß telah diketahui merupakan satu-satunya sel endokrin yang menghasilkan insulin dalam pulau Langerhans di pankreas. Mekanisme autoimun di DM tipe 1 dimulai dari penemuan limfosit T dan B yang memasuki pulau Langerhans di pankreas dan diduga yang menyebabkan kerusakan limfosit T melalui respons imun.…”

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Ketoasidosis Diabetik Di Diabetes Melitus Tipe 1

Ridwan¹,

Bahrun²,

R³

2018

Indonesian J. Clin. Pathol. Med. Lab.

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Type 1 Diabetes Mellitus (DMT1) is an autoimmune disease characterized by impaired carbohydrate, protein and lipid metabolismresulting in insulin deficiency either absolute or relative. The absolute insulin deficiency found in DMT1, is caused by a defect in thepancreatic ß cells leading to a defect in insulin synthesis by the pancreas gland. In this article, a case of type 1 DM in a child withketoacidosis diabetes has been reported. The diagnosis was based on classical symptoms, blood glucose level, C-peptide, metabolic acidosisand keton uria. The case reported is a 12 year old girl, with main complaints of 9 kg body weight loss since three (3) years ago. Thepatient always felt hungry, thirsty and was frequently urinating. In her family history no such case was denied. The patient had beentreated in the district general hospitals for five (5) days and was diagnosed as type 1 diabetes mellitus and was then referred to the Dr.Wahidin Sudirohusodo Hospital. The laboratory test results revealed as follows, random glucose level was 729 mg/dL, arterial blood gasanalysis showed metabolic acidosis, C-peptide was 0.1 ng/mL and urinalysis showed 150 mg/dL protein, 1000 mg/dL glucose, 150 mg/dL ketone and 250 RBC/uL. The patient was diagnosed as type 1 diabetes mellitus with diabetic ketoacidosis and received 0.5 U/kg/dayinsulin therapy. This case report aimed to determine the type 1 diabetes mellitus in a child is accompanied by diabetic ketoacidosis.

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Predictive factors of ketoacidosis in type 1 diabetes mellitus

Listianingrum

Patria

Wibowo

2019

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Background Diabetic ketoacidosis (DKA) is an acute complication in type 1 diabetes mellitus (DM) and a significant cause of morbidity and mortality in developing countries. Diabetic ketoacidosis can be prevented by good management of the disease. Risk factors from previous studies that increase the DKA incidence were peripubertal age, female gender, low socio-economic status, low parental education status, DKA at the first diagnosis of type 1 DM, infection, psychological problems, poor metabolic control, and non-compliance with insulin treatment. Objective To determine whether sex, age, socio-economic status, parental education level, DKA at the initial diagnosis of type 1 DM, infection, psychological problems, poor metabolic control, and failing to take insulin as needed were predictive of DKA in type 1 DM patients. Methods We conducted a retrospective cohort study using medical records from type 1 DM patients aged 0-20 years, at the Department of Child Health, Dr. Sardjito Hospital, Yogyakarta, from January 2011 to May 2017. We assessed for the incidence and predictors of DKA. Logistic regression analysis was done to determine which factors increased DKA incidence. Results A total of 57 type 1 DM patients were recruited, with DKA incidence of 37 (65%). Five (8.8%) DKA patients died. Multivariate analysis revealed that infection (OR 5.23; 95%CI 1.47 to 19.68; P=0.014) and DKA at the first diagnosis of type 1 DM (OR 5.37; 95%CI 1.40 to 19.52; P=0.011) were significant risk factors for DKA. Conclusion Infection and DKA at the first diagnosis of type 1 DM are significant predictors of increased DKA incidence.

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Gambaran Klinis dan Laboratoris Diabetes Mellitus tipe-1 pada Anak Saat Pertama Kali Datang ke Bagian IKA-RSCM Jakarta

Cited by 5 publications

References 2 publications

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Ketoasidosis Diabetik Di Diabetes Melitus Tipe 1

Predictive factors of ketoacidosis in type 1 diabetes mellitus

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