Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice

Gu, Hong-Yan; Qin, You; Liu, Wei; Yang, Yong; Zhao, Li; Qi, Qi; Zhao, Jie; Wang, Jia; Lu, Na; Liu, Hua; Guo, Qinglong; Wang, Xiaotang

doi:10.1016/j.intimp.2008.05.013

Cited by 35 publications

(23 citation statements)

References 18 publications

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“…gA mediates these responses by inhibiting tumor angiogenesis (13), acquiring chemotherapeutic resistance (14), and selectively binding tumor cells (9), among other mechanisms. Several studies also confirmed that GA was equally effective at suppressing the growth of transplanted tumors in animal models (15)(16)(17). Moreover, it was also reported that gA exhibits low toxicity against normal tissues (18,19).…”

Section: Introductionmentioning

confidence: 78%

Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest

Zhao

Zhou²,

Zhang³

et al. 2011

Oncol Rep

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Abstract. the natural product gambogic acid (gA) has been demonstrated to be a promising chemotherapeutic drug for some cancers because of its ability to induce apoptosis and cell cycle arrest. Until now, no studies have looked at the role of gA in osteosarcoma. In this study, we observed the effects of gA on the growth and apoptosis of osteosarcoma cells in vitro. We found that gA treatment inhibits the proliferation of osteosarcoma cells by inducing cell cycle arrest. Moreover, we found that gA induces apoptosis in Mg63, Hos and U2os cells. Furthermore, we showed that gA treatment elevates the Bax/Bcl-2 ratio. gA mediated the g0/g1 phase arrest in U2os cells; this arrest was associated with a decrease in phospho-gsK3-ß (ser9) and the expression of cyclin D1. similarly, in Mg63 cells, gA mediated g2/M cell cycle arrest, which was associated with a decrease in phospho-cdc2 (Thr 161) and cdc25B. Overall, our findings suggest that gA may be an effective anti-osteosarcoma drug because of its capability to inhibit proliferation and induce apoptosis of osteosarcoma cells.

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Section: Introductionmentioning

confidence: 78%

Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest

Zhao

Zhou²,

Zhang³

et al. 2011

Oncol Rep

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“…The molecular formula of GA is C 38 H 44 O 9 (molecular weight, 628.34 g/mol) and its chemical structure is known. GA is an effective anti-tumor agent that has been shown to have multiple effects on several types of solid human tumors in vitro and in vivo (14,15 lymphoma-2 (Bcl-2), inhibiting tumor cell apoptosis (16,17). GA has also been implicated in several mechanisms of cisplatin resistance (18).…”

Section: Introductionmentioning

confidence: 99%

Role of gambogic acid and NaI131 in A549/DDP cells

et al. 2016

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Abstract. Resistance to platinum in tumor tissue is a considerable barrier against effective lung cancer treatment. Radionuclide therapy is the primary adjuvant treatment, however, the toxic side effects limit its dosage in the clinical setting. Therefore, the present study aimed to determine whether an NaI 131 radiosensitizer could help reduce the toxic side effects of radionuclide therapy. In vitro experiments were conducted to determine whether NaI 131 can inhibit platinum resistance in A549/DDP cells, which are cisplatin-resistant non-small cell lung cancer cells, and whether gambogic acid (GA) is an effective NaI 131 radiosensitizer. Cell proliferation following drug intervention was analyzed using MTT and isobolographic analysis. Apoptosis was assessed by flow cytometry. In addition, the mechanisms of drug intervention were analyzed by measuring the expression of P-glycoprotein (P-gP), B cell lymphoma 2 (Bcl-2), Bcl2-associated X protein (Bax) and P53 using western blot analysis and immunocytochemistry. According to isobolographic analysis, a low concentration of NaI 131 combined with GA had a synergistic effect on the inhibition of A549/DDP cell proliferation, which was consistent with an increased rate of apoptosis. Furthermore, the overexpression of Bax, and the downregulation of P-gP, P53 and Bcl-2 observed demonstrated the potential mechanism(s) of NaI 131 and GA intervention. NaI 131 may induce apoptosis in A549/DDP cells by regulating apoptosis-related proteins. A low concentration combination of NaI 131 and GA was able to significantly inhibit A549/DDP cell proliferation and induce cell apoptosis. Thus, the two drugs appear to have a synergistic effect on apoptosis of A549/DDP cells.

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“…1,2 One naturally active product isolated from gamboge resin taken from the Garcinia hanburyi tree is gambogic acid (GA), which has significant antitumor activity. [3][4][5] GA can also induce the apoptosis of cancer cell by suppressing the nuclear factor-κB (NF-κB)-signaling pathway, which in turn suppresses the vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathway. [6][7][8][9] The content of many active components extracted from TCM is very low, and drug research and exploitation based on TCM is costly.…”

Section: Introductionmentioning

confidence: 99%

Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition

Xu¹,

Li²,

Shi³

et al. 2013

IJN

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Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice

Cited by 35 publications

References 18 publications

Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest

Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest

Role of gambogic acid and NaI131 in A549/DDP cells

Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition

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Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice

Cited by 35 publications

References 18 publications

Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest

Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest

Role of gambogic acid and NaI131 in A549/DDP cells

Synergetic effect of functional cadmium&ndash;tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition

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Product

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Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition