Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection

Abstract

Dengue virus (DENV) is a mosquito-borne flavivirus that causes significant global human disease and mortality. One approach to develop treatments for DENV infection and the prevention of severe disease is through investigation of natural medicines. Inflammation plays both beneficial and harmful roles during DENV infection. Studies have proposed that the oxidative stress response may be one mechanism responsible for triggering inflammation during DENV infection. Thus, blocking the oxidative stress response could reduce inflammation and the development of severe disease. Garlic has been shown to both reduce inflammation and affect the oxidative stress response. Here, we show that the garlic active compounds diallyl disulfide (DADS), diallyl sulfide (DAS) and alliin reduced inflammation during DENV infection and show that this reduction is due to the effects on the oxidative stress response. These results suggest that garlic could be used as an alternative treatment for DENV infection and for the prevention of severe disease development.

Ethnopharmacology, biological activity and chemical characterization of <em>Mansoa alliacea</em>. A review about a promising plant from Amazonian region

“…The presence of orgasulfur compounds in other species motivated a wide cluster of studies mainly focused on health promoting effects [46,47,48,49]. These findings and the results presented in the present conference paper justify more pharmaceutical and nutraceutical researches as a new trend of investigation for M. alliacea.…”

Antioxidant activity and leukemia initiation prevention in�vitro and in�vivo by N‑acetyl‑L‑cysteine

“…Several organosulfur compounds of garlic have been shown to exert multiple pharmacological activities (32)(33)(34)(35)(36)(37)(38), and studies have demonstrated that aqueous garlic extract has antioxidant properties (39,40). It is well-known and well-published that garlic extract possessed the strong antioxidant activities in vitro and in vivo (41)(42)(43).…”

Ecoepidemiology of Alphaviruses and Flaviviruses

“…Flaviviruses are arboviruses transmitted to vertebrate hosts by a vector arthropod (ticks and mosquitoes). Some flaviviruses, such as DENV, YFV, WNV, SLEV, Japanese encephalitis virus (JEV), or encephalitis virus transmitted by ticks (TBEV), cause diseases in humans, and the signs can vary from a nonspecific febrile syndrome, encephalitis, hemorrhagic fever, and death (Calisher and Gould, 2003;Hall et al, 2017;Feitoza et al, 2017). The DENV is mainly transmitted by female mosquitoes of the genus A. aegypti and A. albopictus, distributed in all tropical and subtropical countries, both species considered invasive (Rey and Lounibo, 2015).…”