Gastric antisecretory and cytoprotective effects of leaf extracts of Amaranthus tricolor Linn. in rats

Devaraj, V. C.; Krishna, Burdipad G

doi:10.3736/jcim20110915

Cited by 22 publications

(12 citation statements)

References 25 publications

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“…Leaf extracts of the plant have been reported to possess very good antiulcer property in experimental animal models of gastric ulcers (Devaraj and Krishna, 2011). Phytochemical screening studies conducted with the plant have revealed the presence of carbohydrates (Behari and Sharma, 1984), flavonoids like betacyanins A and B, amaranthin, isoamaranthin, and quercetin (Piatteli et al, 1964;Zakharova et al, 1995), and various sterol compounds like spinasterol, cholesterol, campestrol, 24-methylene cholesterol, stigmasterol, -sitosterol, fucosterol, and isofucosterol (Behari and Sharma, 1984;Fernado and Bean, 1984).…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and antinociceptive activity evaluation of methanolic extract of whole plant of <i>Amaranthus Tricolor</i> L. (Amaranthaceae).

Rahmatullah¹,

Hosain²,

Rahman³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Amaranthus tricolor whole plants are used by folk medicinal practitioners of Bangladesh for treatment of pain, anaemia, dysentery, skin diseases, diabetes, and as a blood purifier. Thus far, no scientific studies have evaluated the antihyperglycaemic and antinociceptive effects of the plant. The present study was carried out to evaluate the possible glucose tolerance efficacy of methanolic extracts of A. tricolour whole plants using glucose-induced hyperglycaemic mice, and antinociceptive effects with acetic acid-induced gastric pain models in mice. In antihyperglycaemic activity tests, the extract at different doses was administered one hour prior to glucose administration and blood glucose level was measured after two hours of glucose administration (p.o.) using glucose oxidase method. The statistical data indicated the significant oral hypoglycaemic activity on glucose-loaded mice at all doses of the extracts tested. Maximum antihyperglycaemic activity was shown at 400 mg extract per kg body weight, which was comparable to that of a standard drug, glibenclamide (10 mg/kg body weight). In antinociceptive activity tests, the extract also demonstrated a dose-dependent significant reduction in the number of writhings induced in mice through intraperitoneal administration of acetic acid. Maximum antinociceptive activity was observed at a dose of 400 mg extract per kg body weight, which compared favourably with that of a standard antinociceptive drug, aspirin, when administered at a dose of 200 mg per kg body weight. The results validate the folk medicinal use of the plant for reduction of blood sugar in diabetic patients as well as the folk medicinal use for alleviation of pain. The results suggest that this plant may possess further potential for scientific studies leading to possible discovery of efficacious antihyperglycaemic and antinociceptive components.

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Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and antinociceptive activity evaluation of methanolic extract of whole plant of <i>Amaranthus Tricolor</i> L. (Amaranthaceae).

Rahmatullah¹,

Hosain²,

Rahman³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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“…Moreover, tannins precipitate the microproteins thereby forming an impervious protective pellicle over the ulcerated gastric lining resulting in inhibition of toxic substance adsorption and prevent from further proteolytic enzyme degradation [46]. …”

Section: Discussionmentioning

confidence: 99%

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Ignatius

Narayanan

Subramanian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.

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“…Mechanism of ulcer formation in this model has been shown to involve an increase of oxygen-derived free radicals and a decrease of Cu, Zn, and superoxide dismutase (SOD) activity in the duodenal mucosa 18,24 . Other factors involved include increased duodenal motility 31 decreased duodenal bicarbonate secretion in response to acid 25,26 delayed gastric emptying and enhanced or unchanged gastric secretion. The protective effect of Brassica oleraceae against cysteamine-induced duodenal ulcers could be due to the strengthening of the duodenal mucosa or by other mechanisms like increased gastric and duodenal alkaline secretion or by increased luminal prostaglandin levels 18,27 .…”

Section: Discussionmentioning

confidence: 99%

Antiulcer Activity of Aqueous Extract of Fresh Leaf of Brassica Oleraceae Linn. Var. Acephala (D.C) Alef) (Brassicaceae)

Agbaje¹,

Esther²,

Okpara³

et al. 2013

Int. Res. J. Pharm.

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Brassica oleraceae (BOL) is the common cabbage and a familiar garden plant, widely used as spice all over the world. Cabbage is an excellent source of Vitamin C and has been widely employed locally to treat acute inflammation and peptic ulcers. The present study aimed at evaluating the anti¬ulcer activity of Brassica oleraceae, while identifying the phytoconstituents responsible for the observed effects and exploring some of the possible mechanisms of its anti¬ulcer activity, using standard laboratory procedures. Doses of 100, 300 and 750 mg / kg of Brassica oleraceae were separately administered to groups of overnight fasted rats, with appropriate standard drugs using Ethanol / HCl, Indomethacin and Cysteamine models to explore anti¬ulcer property of BOL on the stomach and duodenum respectively. The extract in a dose¬ dependent fashion, offered better protection against the ulcerogens in the gastric ulcer models, when compared with the positive control groups. However, the smallest dose of 100 mg / kg recorded the highest percentage protection in the cysteamine group. Up to 1200 mg / kg i.p and 10,000 mg / kg oral doses of Brassica oleraceae did not produce any mortality in mice. Phytochemical constituents identified included alkaloids, tannins, cardiac glycosides, flavonoids, phlobatannins, anthraquinones and saponins. The pH was 8.5. The present study has validated the local use of Brassica oleraceae in the treatment of peptic ulcer and the speculated mechanisms of action could be through acid neutralization, cytoprotection and antioxidation by flavonoids

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Gastric antisecretory and cytoprotective effects of leaf extracts of Amaranthus tricolor Linn. in rats

Cited by 22 publications

References 25 publications

Antihyperglycemic and antinociceptive activity evaluation of methanolic extract of whole plant of <i>Amaranthus Tricolor</i> L. (Amaranthaceae).

Antihyperglycemic and antinociceptive activity evaluation of methanolic extract of whole plant of <i>Amaranthus Tricolor</i> L. (Amaranthaceae).

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Antiulcer Activity of Aqueous Extract of Fresh Leaf of Brassica Oleraceae Linn. Var. Acephala (D.C) Alef) (Brassicaceae)

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