Gastric carcinoids: Between underestimation and overtreatment

Massironi, Sara; Sciola, V.; Spampatti, Matilde Pia; Peracchi, M.; Conte, Dario

doi:10.3748/wjg.15.2177

Cited by 46 publications

(38 citation statements)

References 42 publications

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“…Also, immunohistochemical determination of the proliferative index with Ki-67 and evaluation of the mitotic index, by counting number of mitosis per 10 high-power fields, are mandatory, with a negative prognostic meaning when Ki-67 is > 2% and mitotic index is > 2. 12 In our cases the tumor size were ranged from 0.2 to 3 cm in the type I and 1,3 to 8 cm in the type IV gastric carcinoid tumors. Multifocality of the tumor were found in 7 patients with type I gastric carcinoid tumor.…”

Section: Discussionmentioning

confidence: 99%

Gastric Carcinoid Tumors: The Problems Encountered in Diagnosis and Treatment

Yüksel¹

2013

UHOD

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Gastric carcinoid tumors are rare tumors that originate from gastric enterochromaffin-like cells in the oxyntic mucosa and constitute 3.2-4% of all carcinoid tumors. Herein, outcome of a single institution experience with gastric carcinoid tumors were evaluated retrospectively. The patients with gastric carcinoid tumors were analyzed with respect to their presenting signs and symptoms, serum gastrin level, imaging studies, operative procedures and outcome of 21 patients with gastric carcinoid tumor were enrolled in this study. Sixteen patients had type 1 and 5 had type IV gastric carcinoid tumors. Endoscopic biopsy was performed in 15 patients with type I and in 2 patients with type IV. Multifocal tumor was seen in 7 patients with type I. Preoperative serum gastrin levels were high in 11 patients with type I and 3 patients with type IV gastric carcinoid tumor. In the patients with type I gastric carcinoid tumor, endoscopic mucosal resection (EMR) was performed in 6 patients with only one tumor and the tumor size less than 1 cm. In this group, 3 patients had relapse (50%). Total gastrectomy was performed in all the patients with type IV gastric carcinoid tumor. The 5-year survival of type I and IV gastric carcinoid tumors were 69.1% and 48.6%, respectively.

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Section: Discussionmentioning

confidence: 99%

Gastric Carcinoid Tumors: The Problems Encountered in Diagnosis and Treatment

Yüksel¹

2013

UHOD

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“…Somatostatin analogues may also have probably represented an advance in the management of CTs, particularly of gastric tumors, types 1 and 2 (46).…”

Section: Discussionmentioning

confidence: 99%

“…Polish authors (43) analyzed over 50,000 colonoscopies in a screening program for colorectal cancer, and found 25 carcinoids (prevalence: 0.05%) in 24 patients with a mean age of 54 years; maximum tumor size was 10 mm (mean: 6 mm). The increase in gastric CTs may possibly result from screening with gastroscopy and biopsies, as well as from a greater use of immunocytochemistry (positivity for chromogranin and synaptophysin is pathognomonic for carcinoid) (46).…”

Section: Discussionmentioning

confidence: 99%

“…Survival for rectal and gastric CTs has increased over 20% in late reviews, probably due to earlier diagnosis (endoscopy, biopsies, echoendoscopy, CT scanning, and Octreoscan) and treatment (42,46). Somatostatin analogues may also have probably represented an advance in the management of CTs, particularly of gastric tumors, types 1 and 2 (46).…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal carcinoid tumors

Varas-Lorenzo¹,

Muñoz-Agel²,

Espinós-Pérez³

et al. 2010

Rev. esp. enferm. dig.

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Carcinoid tumors (CTs) were described more than 100 years ago by Oberndorfer (1,2). MacDonald (1) found 0.02% carcinoids in surgical cases, and 1% in necropsies.The incidence of carcinoid tumors has increased over time from 0.32/100,000 population and year (3) in the only community-based study available to 1-2 cases/100,000/year (4,5), and then further to 4.4/ 100,000/year (6,7); the rate in surgical specimens and necropsies was 8.4/100,000/year in Sweden during a 12-year period of time (8). The one study in our country (9) points out an incidence of 0.7/100,000 population/year for all CTs (0.125% in necropsies).CTs occur twice as much in Afro-American than in Caucasian patients (10). Gender distribution is similar, REV ESP ENFERM DIG (Madrid) Vol. 102. N.°9, pp. 533-537, 2010 Received: 29-10-09. Accepted: 25-02-10.Correspondence: M. J. Varas Lorenzo. Centro Médico Teknon. C/ Marquesa de Vilallonga, 12. 08017 Barcelona. Spain. e-mail: varas@dr.teknon.es Varas-Lorenzo MJ, Muñoz-Agel F, Espinós-Pérez JC, Bardají-Bofill M. Gastrointestinal carcinoid tumors. Rev Esp Enferm Dig 2010; 102: 533-537. ORIGINAL PAPERS ABSTRACTObjective: carcinoid tumors (CTs) represent the commonest neuroendocrine tumors.Those in the gastrointestinal tract are diagnosed in surgical specimens, clinically, and using imaging techniques (endoscopy, echoendoscopy, CT, Octreoscan, etc.).The goal of this retrospective study was to review a personal series of gastrointestinal carcinoid tumors, and to compare it to those in the literature.Patients and methods: the medical records of 40 Caucasian patients with over 50 gastrointestinal carcinoid tumors (including multiple cases) who were seen for a period of 16 years (1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009) were reviewed.Results: mean age at presentation was 52 years, 50% were females, and mean tumor size was 9.9 mm. Most were gastroduodenal (42.5%) or rectal (30%), and were treated endoscopically. Metastases and carcinoid syndrome (CS) were seen in 5% of patients. Survival at study endpoint was 85%.Conclusions: age and gender were consistent with the literature. There was an increase in gastroduodenal (multifocal) and rectal carcinoids, likely because the series was essentially endoscopical in nature (bias). There was a lower rate of CS and higher survival, likely due to earlier diagnosis and treatment.Key words: Gastrointestinal carcinoid tumors. Neuroendocrine tumors. Carcinoid syndrome. RESUMENObjetivo: los tumores carcinoides (TC) son los tumores neuroendocrinos más frecuentes. Los digestivos se diagnostican en las piezas quirúrgicas, en la clínica, y mediante los métodos de imagen (endoscopia, ecoendoscopia, TAC y Octreoscan, etc.).El objetivo de este trabajo retrospectivo fue revisar una serie personal de tumores carcinoides digestivos y compararla con la literatura.Pacientes y métodos: se revisaron las historias clínicas de 40 pacientes de raza blanca con más de 50 tumores carcinoides digestivos, algunos múltiples, observados du...

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“…to control gastrin secretion), in conjunction with endoscopic surveillance and resection of prominent tumors. 22,23,40,42 Furthermore, the oral gastrin receptor antagonist netazepide (YF476) is under study as an alternative therapeutic option for patients with type I gastric NETs and has been shown to cause tumor regression and normalize chromogranin A levels in 2 small prospective studies. 43,44 As in type I and II gastric NETs, systemic therapy in type III is warranted only in locoregional disease that is unresectable or metastatic.…”

Section: Medical Managementmentioning

confidence: 99%

Gastric neuroendocrine tumors: management and challenges

Kwon¹,

Nakakura²,

Bergsland³

et al. 2017

GICTT

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Gastric neuroendocrine tumors derive from enterochromaffin-like cells in the stomach mucosa. Based on histologic, serologic, and endoscopic findings, they may be further differentiated into types I, II, and III, with varying degrees of aggressiveness. In this article, diagnostic and classification strategies are reviewed, as are endoscopic, systemic, and surgical modalities for management. A multidisciplinary approach is advocated to provide the most effective patient care.

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Gastric carcinoids: Between underestimation and overtreatment

Cited by 46 publications

References 42 publications

Gastric Carcinoid Tumors: The Problems Encountered in Diagnosis and Treatment

Gastric Carcinoid Tumors: The Problems Encountered in Diagnosis and Treatment

Gastrointestinal carcinoid tumors

Gastric neuroendocrine tumors: management and challenges

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