Gastric neuroendocrine tumors: management and challenges

Kwon, Daniel H.; Nakakura, Eric K.; Bergsland, Emily K.; Dai, Sun-Chuan

doi:10.2147/gictt.s109028

Cited by 8 publications

(19 citation statements)

References 51 publications

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“…El tratamiento que se menciona en la literatura, destaca que la terapia sistémica en el tumor neuroendocrino tipo III está garantizado solo en la enfermedad locorregional irresecable o metastásica, si estos tumores están bien o pobremente diferenciados, la cirugía ofrece el mejor control oncológico para enfermedad localizada [1,15,16].…”

Section: Discussionunclassified

“…A diferencia de los neuroendocrinos gástricos de tipo I y II, el tratamiento de elección del tipo III es el quirúrgico con gastrectomía total o subtotal con la disección de los ganglios linfáticos regionales [1,16].…”

Section: Conclusionesunclassified

“…Los tumores neuroendocrinos representan las neoplasias neuroendocrinas más frecuentes y son cada vez más diagnosticadas debido a la creciente utilización de la endoscopia digestiva alta como medio diagnóstico para múltiples patologías digestivas [1,2]. Los tumores neuroendocrinos con localización gástrica son tumores de muy baja frecuencia, constituyendo el 1.8 % aproximadamente de los tumores gástricos que derivan de células enterocromafines en la mucosa gástrica; sin embargo, el número de carcinoides gástricos reportados está aumentando de 0.3 casos por millón en 1 981 a 1.8 casos en 2 000 y más de 2.5 casos por millón en 2010 [3 -5].…”

Section: Introductionunclassified

“…La supervivencia de estos pacientes es pobre, siendo el 75 -80 % a los cinco años en comparación a 90 -95 % para el tipo I. Mediante endoscopia digestiva alta con biopsia, se observa una sola lesión en la mucosa gástrica normal con un tamaño mayor de 2 cm[8,13]. Este paciente recibió un diagnóstico de carcinoide gástrico tipo III, sin embargo, al momento no se observó metástasis, aunque sí se observó afectación de los ganglios linfáticos regionales.En relación al tratamiento, específicamente de los tumores neuroendocrinos tipo III, un enfoque razonable es la resección quirúrgica debido a la alta capacidad proliferativa y frecuente compromiso ganglionar al momento de la presentación clínica, como se observó en el presente caso[1,11].…”

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Caso Clínico: Tumor Neuroendocrino Gástrico

et al. 2018

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BACKGROUND: Gastric neuroendocrine are very low tumors prevalence, constituting approximately 1.8 % of gastric tumors. They are usually solitary, with a size between 4 and 8 cm, most often in the male with average age of presentation between 60 - 70 years. It is diagnosis is increasing, thanks to the widespread use of upper digestive endoscopy, this being the gold standar. Regarding it is treatment; surgical resection of gastric neruroendocrine tumors is one of the choices when endoscopic resection is not possible. CASE REPORT: 45-year-old patient refers epigastralgia, nauseas and diarrhea, since two months ago. Upper digestive endoscopy is performed with report of Forrest III antrum ulcer. Biopsy: grade II neuroendocrine tumor. Abdominal tomography: no activity data in another place outside the stomach. EVOLUTION: Subtotal gastrectomy was performed, with a negative report in the transoperative study of peritoneal lavage fluid. The pathology report confirmed the diagnosis of unifocal neuroendocrine GII 3.5 cm tumor; in stage III B according to clinical guidelines, with surveillance for a period of one year without tumor activity. CONCLUSION: The gastric neuroendocrine is a rare type of cancer; upper gastrointestinal endoscopy was a fundamental in the diagnosis of this case that led the patient to seek medical evaluation. However, to reduce it is incidence is recommended to eat a diet rich in fruits, and fresh vegetables accompanied by adequate physical activity.

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Caso Clínico: Tumor Neuroendocrino Gástrico

et al. 2018

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“…defines and differentiated neuroendocrine tumor made of cells with structures similar to those which are normal endocrine gut cells. They express universal indicators of neuroendocrine differentiation and hormones according to site having mild to moderate nuclear atypical and low number of mitosis [8].…”

Section: Whomentioning

confidence: 99%

Abdominal Ganglion Neuro Endocrin Neoplasm: A Case Report

Rehman¹,

Sarwar²,

Afzal³

2019

SJNHC

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Introduction: The neuroendocrine neoplasms (NENs) are comparatively infrequent and mixed tumors which comprise 2% of all malignancies, with an incidence of <200,000 population. Gastrointestinal neuroendocrine carcinomas are diagnosed rarely. While gastric carcinoma is third principal reason of death in men and fifth in women especially in Eastern Asia. Case Report: We, herein, present a patient of 30 years and male who was presented to OPD having complaints of diarrhea, hot flushes, dizziness, dyspepsia and anorexia. A Core Biopsy of left par aortic region was made. The findings showed that patient was suffering from neuroendocrine neoplasm/paraganglioma. Initially, lesions can be managed by endoscopic excision of accessible tumors and endoscopic monitor. Discussion: Abdominal neuroendocrine carcinomas are also rare and accounting for less than 10% of gastric neoplasms and such rareness has made it tough to accurately recognize their organic nature and to identify ideal treatment choices. Conclusion: As we described a patient of intermittent gastric neuroendocrine carcinoma, a well-managed description of these cancers/tumors should be discussed globally and historically. Diagnostics and therapeutic managements must be evaluating in large clinical studies.

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Gastric Peptides—Gastrin and Somatostatin

Schubert

Rehfeld

2019

Comprehensive Physiology

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Gastric neuroendocrine tumors: management and challenges

Cited by 8 publications

References 51 publications

Caso Clínico: Tumor Neuroendocrino Gástrico

Caso Clínico: Tumor Neuroendocrino Gástrico

Abdominal Ganglion Neuro Endocrin Neoplasm: A Case Report

Gastric Peptides—Gastrin and Somatostatin

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