Gastric carcinoma in the dog: A clinicopathological study of 11 cases

Fonda, D.; Gualtieri, M.; Scanziani, Eugenio

doi:10.1111/j.1748-5827.1989.tb01579.x

Cited by 55 publications

(77 citation statements)

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“…32 Our results show a male to female ratio of 12:5, similar to proportions reported in previous studies and possibly indicating a male predisposition. 9,12,13,39 The mean ages of males and females with gastric carcinoma were 9.7 and 8.1, respectively. …”

Section: Discussionmentioning

confidence: 99%

“…Sixty percent to 70% of gastric tumors are malignant. 9,12,13,15,32,33,43 The World Health Organization (WHO) classifies gastric carcinomas in domestic animals according to the growth pattern of the carcinomas, dividing them into 5 types: tubular carcinoma, mucinous carcinoma, signet ring cell carcinoma, undifferentiated carcinoma, and papillary carcinoma. 15 The relationship between the histological type of carcinoma and other characteristics of malignancy related to the prognosis has not been previously described.…”

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confidence: 99%

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Canine Gastric Carcinoma

et al. 2010

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Immunohistochemical staining for cell cycle proteins and heat shock proteins was performed on 17 canine gastric carcinomas. The immunoexpression of p53, p21, p16, Hsp27, and Hsp70 was investigated. A study was conducted to determine the histological type and parameters related to tumor malignancy. Possible associations and trends were assessed between the immunoexpression of each protein and tumor type as well as specific parameters of malignancy. High intratumor frequency of cellular p53 immunostaining was observed (61.96% average), but lower frequencies of p21 and p16 expression were present (34.65% and 10.41%, respectively). The p53 overexpression was associated with tumor infiltration (P ¼ .0258). Expression of p21 was lower in undifferentiated carcinomas, and the loss of expression was associated with histopathological parameters characteristic of a poor prognosis such as lymphatic vessel invasion (P ¼ .0258). The lack of p16 immunoreactivity was related to histopathological characteristics of malignancy such as the presence of evident and multiple nucleoli (P ¼ .0475). In contrast, deep tumor infiltration was observed in those carcinomas with a high p16 index (P ¼ .0475). Hsp70 appeared to be overexpressed in all gastric neoplasms included in this study. This is in contrast to Hsp27, because a group of tumors showed complete lack of Hsp27 immunoexpression, whereas the others displayed extensive Hsp27 immunostaining. The differences in Hsp27 did not correlate with any of the histopathological parameters, but Hsp27 immunoexpression was higher in the undifferentiated carcinoma. No significant differences in the expression of the proteins were found in canine gastric carcinomas according to their histological type. These findings may be useful for establishing a prognosis for canine gastric carcinoma.

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Section: Discussionmentioning

confidence: 99%

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Canine Gastric Carcinoma

et al. 2010

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“…Canine gastric carcinomas frequently metastasize to gastric lymph nodes, liver, spleen, peritoneum, and lung, leading to a poor prognosis for patients. 7 The most commonly occurring canine gastric tumor is a poorly differentiated signet ring gastric carcinoma (WHO) with excessive fibrosis and invasive growth; these generally have a worse prognosis than that of the less frequently occurring well-differentiated tubular carcinomas (WHO). 11,12 In humans, more extensive invasion of tumor cells and more frequent metastasis are associated with advanced signet ring (WHO) and diffuse (Lauren) gastric carcinomas.…”

Section: C2-o-slementioning

confidence: 99%

“…2,7,25 The majority (70 to 90%) of canine gastric tumors are carcinomas. 26,32 In both dogs and humans, prognosis is generally poor owing to the advanced state of the disease at the time of diagnosis.…”

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“…11,36 The Goseki and Lauren human classifications may more accurately predict prognosis based solely on histopathologic features, 9,15,29 and the latter scheme has been successfully adapted to the dog. 7,26 The Goseki and Lauren classifications have also been used to investigate the pathogenesis, metastasis, and prognosis of human gastric carcinomas. 10,19,29 Thus far, the TNM classification system has been the most accurate predictor of prognosis, wherein T indicates the size or direct extent of the tumor; N, the degree of spread to regional lymph nodes; and M, the presence of metastasis.…”

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The Novel Carbohydrate Tumor Antigen C2-O-sLe^xIs Upregulated in Canine Gastric Carcinomas

2010

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Sialyl Lewis x-modified core 2 branched O-glycans (C2-O-sLe x ) on human leukocytes mediate much higher-affinity adhesion to selectins on activated vascular endothelium than does sialyl Lewis x on other structures. In some canine and human carcinomas, high expression of sLe x -decorated carbohydrates has been associated with metastasis and, in humans, a poor prognosis, but detection in canine gastric carcinomas is unreported. The authors hypothesized that these carbohydrates are highly expressed in more malignant types of canine gastric carcinomas, they promote metastasis, and they are associated with a poorer prognosis for dogs. The objectives were to determine the presence and importance of C2-O-sLe x expression in canine gastric carcinomas. Routine histological sections of 16 canine gastric carcinomas were categorized on the basis of 3 classification schemes: World Health Organization, Lauren, and Goseki. Serial sections were stained with antibodies directed against C2-O-sLe x (CHO-131 monoclonal antibody), cytokeratin (Lu-5 monoclonal antibody), and stains to detect neutral and acid mucins (periodic acid-Schiff and alcian blue). Whereas normal gastric mucosal epithelial cells were negative for C2-O-sLe x , 56% of the tumors examined were positive for C2-O-sLe x . Importantly, the majority of more poorly differentiated tumor types had more numerous and larger intensely stained areas of C2-O-sLe x expression compared with moderate to well-differentiated tumor types. Signet ring-type carcinomas had markedly higher distribution and intensity of periodic acid-Schiff and alcian blue staining than did tubular carcinomas. These findings suggest that C2-O-sLe x is a tumor-associated antigen that may play a role in the invasiveness and metastatic potential of certain types of canine gastric carcinomas.

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