Gastric metastasis of bilateral breast cancer

Abstract

Breast cancer is the most common malignancy in women. The most frequent metastatic sites are lung, bone, liver and brain. On the other hand, gastric metastases are rare. Synchronous bilateral breast cancer (SBBC) occurs rarely. Lobular carcinoma is the histological type most often associated with bilateral breast carcinomas and gastric metastases. We made a retrospective study including four patients followed in the Salah Azaiez Institute, for a bilateral breast cancer with gastric metastases. We analyzed the epidemiological, anatomoclinical and therapeutic particularities of this rare entity. Symptoms were unspecific. The diagnosis of gastric metastasis of the SBBC was confirmed by a histopathological examination of an endoscopic biopsy. The median age was 46.2 years (range, 36-51 years) and the median time until the gastric involvement was 19 months (range, 0-41 months). None of patients had a surgical treatment for the gastric location. All Patients received at least one line of chemotherapy and radiotherapy. Median survival following the detection of gastric involvement was 22 months (range, 1-56 months). Gastric metastases from breast cancer are rare and frequently associated with other distant metastasis. Symptoms are unspecific and endoscopy may not be contributive. Therefore, gastric involvement is underestimated. Lobular infiltrating carcinoma (LIC) is the most histological type incriminated in its occurrence. The supply of immunohistochemistry is crucial to distinguish between primary or metastatic gastric cancer.

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

“…Detailed immunohistochemically analysis is the only relevant method for distinction between metastatic and primary gastric carcinoma, taking into account that metastases of lobular cancer generally keep approximately the same receptor status as the primary breast carcinoma (50)(51)(52).…”

Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>

“…Gastric cancer (GC) is one of the most common, lethal neoplasms of the human digestive system and is the second most frequent cause of cancer-associated death worldwide ( 1 ). The highly aggressive advanced GC promotes distant metastasis, with typical metastatic sites being the lungs, liver and bones ( 2 ). Angiogenesis mostly be essential for nourishing the primary tumor ( 3 ).…”

Gastric Metastasis Mimicking Linitis Plastica 20 Years after Primary Breast Cancer. A Case Report

“…The time interval between initial diagnosis and distant metastases can be up to many years [2]. M e t a s t a s e s t o t h e gastrointestinal tract are rare and do not exceed 5% of the cases [3] with the stomach being the most frequent metastatic site [4,5]. Although gastric metastases from primary gynecological tumors are scarce, those from breast cancers seem to be more frequent than those from the ABSTRACT Breast cancer metastases to the gastrointestinal tract are rare, with a median time interval from the diagnosis of the primary tumor to metastasis up to 7 years.…”

“…DOI: http://dx.doi.org/10.15403/jgld.2014.1121.274.gas uterus or the ovaries [6]. Lobular carcinoma of the breast has more affinity to the gastrointestinal tract than the other types [4], with an incidence of 4.5% compared to 0.2% in ductal carcinoma [7]. The mean time interval between the diagnosis of primary breast cancer and the appearance of gastric metastases usually ranges from 5 to 7 years [2,6,8].…”