Gastric <scp>H</scp>elicobacter pylori infection associated with risk of diabetes mellitus, but not prediabetes

Yang, Gi Hua; Wu, Jin Shang; Yang, Yi Ching; Huang, Ying; Lu, Feng Hwa; Chang, Chih Jen

doi:10.1111/jgh.12617

Cited by 35 publications

(21 citation statements)

References 41 publications

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“…Yang et al. reported a significant association between H. pylori infection and diabetes by studying 1285 subjects aged 19–85 years, while similar results were obtained by other authors from India . Similarly, Horikawa et al.…”

Section: Diabetes Mellitussupporting

confidence: 74%

Extragastric Diseases and Helicobacter pylori

Franceschi¹,

2015

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The extragastric manifestations of Helicobacter pylori infection still remain a very strong topic throughout the H. pylori world. Indeed, H. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that H. pylori may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions. Different pathogenic mechanisms have been hypothesized, including the induction of a low-grade inflammatory state and the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic in the last year.There is a very strong interest of researchers from all over the world in the extragastric manifestations of Helicobacter pylori infection, as demonstrated by the high number of studies published in this field during the last year. Indeed, H. pylori is a very good model for studying host-bacterial interactions and very attractive for those interested in the role of gut microbiota in health and disease [1]. Here, we shall summarize the results of the most relevant studies published on this topic from

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Section: Diabetes Mellitussupporting

confidence: 74%

Extragastric Diseases and Helicobacter pylori

Franceschi¹,

2015

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“…Yang et al. also reported a significant association between H. pylori infection and DM (OR: 1.42, 95% CI: 1.01–2.01), but not with prediabetes (OR: 1.02, 95% CI: 0.77–1.36). Interestingly, the possible role of H. pylori in complications of DM has been also investigated.…”

Section: Diabetes Mellitusmentioning

confidence: 92%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic over the last year.

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“…Some epidemiological studies indicate a higher prevalence of H. pylori infection in patients with diabetes121314. In cross-sectional studies, H. pylori infection has been associated with insulin secretion, Hemoglobin A1c (HbA1c), and diabetes1516. There is only one prospective study which investigated the influence of H. pylori infection on the incidence of diabetes.…”

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confidence: 99%

The Impact of Gastric Atrophy on the Incidence of Diabetes

Wei

Kuo

et al. 2017

Sci Rep

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Gastric atrophy results in lower plasma ghrelin, higher gastrin secretion, a change in gut microbiota, and altered dietary nutrient absorption, which may be associated with the incidence of diabetes. Helicobacter pylori (H. pylori) infection is a major cause of gastric atrophy and is associated with diabetes in some reports. Since there is no study which investigates the impact of gastric atrophy on diabetes, we conduct a prospective cohort study to examine the relationship between H. pylori infection, gastric atrophy, and incident diabetes. In this study, subjects with gastric atrophy had a lower risk of incident diabetes, compared to those without gastric atrophy. The extent of gastric atrophy, measured by serum pepsinogen (PG) I/II ratio, was correlated with age, H. pylori IgG titer, HOMA2-IR, and HOMA2%B. When gastric atrophy is more extensive, presented as a lower serum PG I/II ratio, the risk of incident diabetes is lower. On the other hand, there was no significant association between H. pylori infection and the incidence of diabetes. In conclusion, the presence and the extent of gastric atrophy, but not H. pylori infection, are associated with incident diabetes. Further studies are needed to investigate the detailed mechanisms and the potential applications of the findings to guide diabetes screening and treatment strategies.

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Gastric Helicobacter pylori infection associated with risk of diabetes mellitus, but not prediabetes

Abstract: Gastric H. pylori infection is associated with diabetes, but not prediabetes.

Cited by 35 publications

References 41 publications

Extragastric Diseases and Helicobacter pylori

Extragastric Diseases and Helicobacter pylori

Helicobacter pylori and Extragastric Diseases

The Impact of Gastric Atrophy on the Incidence of Diabetes

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