Gastroenteritis in infants, associated with a genome type of adenovirus 31 and with combined rotavirus and adenovirus 31 infection

Abstract

In an infants' ward, gastroenteritis occurred in five children in two groups, probably by nosocomial spread of adenovirus 31 (three cases) and adenovirus 31 + rotavirus (two cases). The infants recovered well. The DNA of adenovirus 31 isolates was analysed with ten restriction endonucleases and found identical for all five strains, but different from the prototype.

Epidemiology of enteric adenovirus infection in prospectively monitored Argentine families

“…Most AV serotypes may be excreted in faeces, sometimes for long periods, as with AN' group C [4]. The role of AV other than EAV' in gastroenteritis has recently been suspected [5], although their causal role has not been proved.…”

“…Most AV serotypes may be excreted in faeces, sometimes for long periods, as with AN' group C [4]. The role of AV other than EAV' in gastroenteritis has recently been suspected [5], although their causal role has not been proved.EAV are difficult to culture and alternative methods, such as immunoassay techniques [6], DNA restriction analysis [7] or molecular hybridization [8], are currently used for diagnosis. EAV usually infect and cause symptoms in children up to 3 years old, but mainly in those 2 years old or younger [9].…”

Genome type analysis of adenovirus 31, a potential causative agent of infants' enteritis

“…Adenoviruses of subgenus A, mostly isolated from the faeces of infants, are statistically associated with enteritis [14]. AV 31 was often isolated from infants with gastroenteritis in small outbreaks [3,5,8,10,21]. AV31 also was found in an outbreak of respiratory and enteric disease [20], in four cases of Kawasaki syndrome [17], or as disseminated infection of an immunocompromized infant [ 12].…”

“…The genomic variability of AV strains, as shown by DNA restriction analysis, may give clues to epidemiology and pathogenicity [ 18]. Little is known on the genetic variability of subgenus A viruses [3,8]. Therefore we decided to submit 21 AV31 strains, isolated between 1974 and 1987, to DNA restriction analysis with a number of endonucleases, to reveal the variability of this virus type.…”

Subgroup F adenovirus growth in foetal intestinal organ cultures

“…It is possible that the subgroup F adenoviruses utilise a similar mechanism to that of the subgroup A adenoviruses for down-regulating class I antigens [2]. The common feature of tropism for the gastrointestinal tract of both these adenovirus subgroups and a definite (subgroup F) [3,21] and emerging (subgroup A) [1] association with paediatric diarrhoeat illness suggests that they may be subject to the same immune pressures and may have evolved similar mechanisms to ensure their survival.…”