Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms

Annibale, Bruno; Capurso, Gabriele; Chistolini, Antonio; D’Ambra, G.; DiGiulio, E.; Monarca, Bruno; DelleFave, Gianfranco

doi:10.1016/s0002-9343(01)00883-x

Cited by 189 publications

(178 citation statements)

References 35 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…Worldwide prevalence of CD among patients with iron deficiency anemia is 2.8-8.7% and may be as high as 15%. 20,21 Folate and B 12 deficiency may contribute to anemia in CD, and surprisingly, anemia of chronic disease is relatively common. 22 The diagnosis of CD was confirmed by serological detection of the AGA and ATTGA.…”

Section: Discussionmentioning

confidence: 99%

Celiac disease in the Red Sea state of Sudan

Ageep

2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Celiac disease in the Red Sea state of Sudan

Ageep

2012

View full text Add to dashboard Cite

show abstract

“…Some patients with refractory IDA have no gastrointestinal symptoms but H pylori gastritis, as the only cause of their anemia [6] . Most dietary iron is in the non-hemic ferric form, and an acidic intragastric pH is needed to reduce it to the ferrous form for absorption.…”

Section: Introductionmentioning

confidence: 99%

Effects ofH pyloritherapy on erythrocytic and iron parameters in iron deficiency anemia patients withH pylori-positive chronic gastristis

Chen

Luo²

2007

WJG

View full text Add to dashboard Cite

AIM: To elucidate the influences of H pylori infection on oral iron treatment for iron deficiency anemia (IDA). METHODS:A total of 86 patients were divided into two groups: group A, receiving ferrous succinate combined with triple therapy for H pylori eradication, and group B (control), treated with ferrous succinate only. During treatment of IDA, dynamic changes in hemoglobin (Hb) level, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), serum iron (SI), and serum ferritin (SF) were compared between the groups. RESULTS:Hb was slightly higher in group A at d 14 after the start of triple therapy for H pylori eradication (P > 0.05). After the therapy, the increase of Hb in group A became significantly faster than that in group B (P < 0.05). At d 56, the mean Hb in group A returned to the normal level, however, in group B, it was lower than that in group A (P < 0.05) although it had also increased compared with that before oral iron treatment. The MCV and MCH in group A recovered to the normal level, and were much higher than those in group B (P < 0.05) at d 21. In Group B, the MCV and MCH remained at lower than normal levels until d 42 after the start of therapy. And then, they reached a plateau in both groups and the differences disappeared (P > 0.05). The SF in group A was higher than that in group B (P < 0.05) 28 d after the treatment and its improvement was quicker in group A (P < 0.05) , and the difference between the two groups was even more significant (P < 0.01) at d 56. The SI in group A was higher than that in group B (P < 0.05) at d 14 and this persisted until d 56 when the follow-up of this research was finished. CONCLUSION:

show abstract

“…İlk işlem genelde üst endoskopik incelemedir (14). Hb değerlerinin hastalığın ciddiyeti ile ilişkili olmadığı ve gastrointestinal semptomların her iki grupta da genellikle hastalığa eşlik etmediği gösterilmiştir (15). Bizim merkezimizde de DEA'da ilk tercihimiz sıklıkla üst GİS incelemesidir.…”

Section: Discussionunclassified

“…Farklı bir çalışmada DEA olan 668 olguda, bariz kanama, yetersiz diyet, kronik hastalıklar ve malignensi dışlandıktan sonra 71 hastaya (51 kadın) antral ve duodenal biyopsili gastroskopi ve kolonoskopi yapılmış ve tüm hastaların %85'inde DEA'nın nedeni bulunmuştur (15). Ülkemizde yapılan farklı bir çalışmada ise gastrointestinal sistemden kronik kanaması olduğu düşü-nülen 72 olgunun tamamına alt ve üst endoskopik inceleme yapılmış ve %16,6'sında alt, %61'inde üst gastrointestinal lezyon saptanmıştır.…”

Section: Discussionunclassified

Demir eksikliği anemisi olan hastalarda alt ve üst gastrointestinal endoskopik inceleme sonuçları

Okuturlar¹,

Soylu²,

İnan³

et al. 2015

Endoskopi Gastrointestinal

View full text Add to dashboard Cite

Lower and upper endoscopic examination results in patients with iron deficiency anemiaGiriş ve Amaç: Gastrointestinal sistem kaynaklı kronik kan kaybı, erkek ve postmenapozal kadınlarda demir eksikliği anemisinin en sık nedenidir. Bu çalışmada, demir eksikliği anemisi nedeni ile endoskopi uygulanan hastaları, endoskopik yaklaşım ve etyolojik tanı yönünden inceledik. Gereç ve Yöntem: Ocak 2012 ve Haziran 2013 tarihleri arasında endoskopik inceleme yapılan 181 (K=121, E=60) olgu retrospektif olarak değerlendirildi. Çalışmaya hemoglobin düzeyi kadınlarda <10 gr/dl, erkeklerde <12 gr/dl ve demir eksikliği anemisi bulguları olan hastalar dahil edildi. Kesin tanıları endoskopik biyopsi sonuçlarına göre belirlendi. Bulgular: Olguların ortalama yaşları 56±17,2 (18-86) ve yatış süreleri ortalama 11,8±7 gün idi. Erkeklerde ortalama hemoglobin 8,5±3,1 g/dl, kadınlarda 8,5±3,6 g/dl olarak bulundu. Hastaların 107 (%59)'sine sadece gastroskopi, 53 (%29,3)'üne gastroskopi ve kolonoskopi, 21 (%11,6)'ine ise kolonoskopi uygulandı. Gastroskopik inceleme (n=160) uygulananların %22,5'inde eroziv gastrit, %21,3'ünde pangastrit, %11,3'ünde antral gastrit, %10'unda atrofik pangastrit, %8,1'inde gastrik ülser, %8,1'inde polip, %5'inde opere mide, %3,1'inde gastrik tümör, %2,5'inde duodenal ülser, %5'inde diğer nedenler tespit edildi. Kolonoskopik inceleme (n=74) sonucunda ise; %31'inde hemoroid, %20,2'sinde polip, %6,7'sinde kolon tümörü, %5,4'ünde polip ve hemoroid, %4'ünde kolonda divertiküller, %4'ünde anjiodisplazi ve 1'er hastada (%1,3) inflamatuvar barsak hastalığı, iskemik kolit ve divertiküller, anal ülser ve terminal ileit vardı. Ayrıca bir hastada da polip, divertiküller ve hemoroid görüldü. Tüm hastaların %5,5'ine malignite tanısı kondu. Sonuç: Demir eksikliği anemisine neden olan etyoloji oranları literatür ile uyumluydu. İleri yaş olgularda atrofik gastrit önemini korumaktadır. Tüm yaşlarda hemoroid en sık etyolojik nedendir. Demir eksikliği anemisinde üst gastrointestinal sistem patolojisine daha sık rastlanmakla birlikte; gastrointestinal kayıp düşünülen hastalarda alt ve üst endoskopik incelemenin birlikte yapılması, kesin tanının konması açısından önemlidir.Anahtar Kelimeler: Demir eksikliği anemisi, gastroduodenoskopi, kolonoskopi Background and Aims: Chronic blood loss caused by the gastrointestinal system is the most common cause of iron deficiency anemia in men and postmenopausal women. In this study, patients who underwent endoscopy as a result of iron deficiency anemia were examined in terms of endoscopic approaches and etiological diagnosis. Methods: 181 patients (60 males, 121 females) who underwent endoscopic examination between January 2012 and June 2013 were evaluated retrospectively. Patients with hemoglobin <10 g/ dl in women, hemoglobin <12 g/dl in men and patients with iron deficiency anemia were enrolled in this study. The definitive diagnosis was determined according to the results of endoscopic biopsy. Results: The mean age of the patients was 56±17.2 (18-86), and the mean duration of hospitalization ...

show abstract

Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms

Cited by 189 publications

References 35 publications

Celiac disease in the Red Sea state of Sudan

Celiac disease in the Red Sea state of Sudan

Effects ofH pyloritherapy on erythrocytic and iron parameters in iron deficiency anemia patients withH pylori-positive chronic gastristis

Demir eksikliği anemisi olan hastalarda alt ve üst gastrointestinal endoskopik inceleme sonuçları

Contact Info

Product

Resources

About