Gastrointestinal stromal tumor

Gupta, Pranshu; Tewari, Mallika; Shukla, H. S.

doi:10.1016/j.suronc.2007.12.002

Cited by 66 publications

(62 citation statements)

References 80 publications

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“…Liver resection is not advisable as secondaries often involve both the lobes. Surgical therapy may be especially appropriate for patients who do not have access to second-line inhibitor of receptor tyrosine kinases further medical therapy [23].…”

Section: Fine-needle Biopsymentioning

confidence: 99%

Gastrointestinal Stromal Tumours: Review of 150 Cases from a Single Centre

2013

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Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the gastrointestinal tract. They constitute a significant percentage ranging from 1-2 % of all the gastrointestinal neoplasms [11]. Knowledge on the molecular biology and behavior of these tumours is still not very clear. The clinicopathologial features are variable and surgical resection with chemotherapy is the main modality of treatment. We have retrospectively analyzed the clinicopathological features, treatment and prognosis of 150 patients managed in the Department of Surgery. Retrospective review of the records of 150 patients diagnosed with gastrointestinal stromal tumours and managed during the period January 2006 to December 2011. Clinicopathological features, immunohistochemistry, mitotic index, surgical resection adjuvant chemotherapy and survival analyzed. One hundred and fifty patients diagnosed with GIST and treated were reviewed. Ninety five of them were males (63.3 %). The tumour was most commonly seen during the fourth and fifth decades of life. Abdominal pain (52 %), intestinal bleeding (40 %) and abdominal mass (25 %) were the common clinical symptoms. Sixty percent of the tumours (90/150) were located in the stomach followed by small bowel (20 %) and duodenum (14.6 %). One hundred and thirty-five patients underwent excision of the tumour and five patients had multi organ resection of the adjacent organs like spleen, tail of the pancreas and kidney.

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Section: Fine-needle Biopsymentioning

confidence: 99%

Gastrointestinal Stromal Tumours: Review of 150 Cases from a Single Centre

2013

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“…Gastrointestinal sistemin primer tümörlerinin %1 inden azını oluşturmaktadır. GİST yerleşim yerinde göre ve tümör boyutuna göre farklı semptomlar ve bulgularla ortaya çıkabilmektedir 6 . Mezenkimal kaynaklı olması, etraf dokulara invazyon göstermemesi ve lenfatik yayılımı olmaması nedeniyle semptom vermeden büyük boyutlara ulaşabilmektedir.…”

Section: Discussionunclassified

Proximal Jejunal Gastrointestinal Stromal Tumor And Emergency Surgery: A Case Report

Şahin¹,

Türk²,

Polat³

2015

Sakarya Med J

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Gastrointestinal stromal tümörler (GİST) gastrointestinal sistemin en yaygın mezenkimal tümörleridir. En sık görülen lokalizasyonlar mide (%50-60) ve ince barsak (%20-30) dır. Tümör boyutunun artışı ile semptomatik hale gelmekte ve acil cerrahi gereksinimi artmaktadır. Elli iki yaşında bir erkek hasta akut batın bulguları ile başvurdu. Acil cerrahi uygulandı ve 10x9x3 cm boyutunda kitle temiz cerrahi sınırlarla rezeke edildi. Histopatolojik incelemesinde gastrointestinal stromal tümör olduğu saptandı. Bu vakayı hem nadir olarak karşılaşılması hem de acil cerrahi müdahele gereksinimi olabileceğini hatırlatmak amacıyla sunduk.

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“…El uso del imatinib se extiende a la enfermedad con metástasis o residual, con intención neoadyuvante y habiendo datos positivos en el contexto adyuvante. El sunitinib es usado como segunda línea, cuando fracasa el imatinib (después de haber aumentado la dosis) o en los casos de intolerancia al imatinib (15).…”

Section: Discussionunclassified

Tumores del estroma gastrointestinal: Estudio retrospectivo de 43 casos

Alberto

Sánchez

Oliveira

et al. 2008

Rev. esp. enferm. dig.

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RESUMENIntroducción: los tumores del estroma gastrointestinal (GIST) son poco frecuentes, con una incidencia de 10 a 20 casos por millón de habitantes y año. Aparecen en todo el tubo digestivo, mesenterio o epiplón adyacente; siendo más frecuentes en el estó-mago (60-70%); también pueden aparecer en el intestino delgado (20-25%), colon y recto (5%) y esófago (< 5%). Su presentación varía desde pequeños nódulos asintomáticos hasta formas más agresivas. Su clasificación se realiza actualmente con base a los criterios de Fletcher.Objetivo: revisión y caracterización de los casos de GIST observados en nuestro centro durante un periodo de 10 años.Métodos: estudio retrospectivo de pacientes diagnosticados con GIST (identificados por criterios inmunohistoquímicos) desde enero de 1997 hasta diciembre de 2007 y clasificados por los criterios de Fletcher.Resultados: se estudiaron 43 pacientes (24 hombres y 19 mujeres), con una edad media de 62,7 años. La mayoría de los GIST encontrados se localizaban en el estómago (n = 20, 46,5%), intestino delgado (n = 18, 41,9%) y en 5 casos se detectaron como metástasis de un tumor oculto. Dieciocho casos fueron asintomáticos. Por los criterios de Fletcher 19 eran casos de alto riesgo, 7 de riesgo intermedio, 12 de bajo riesgo y 5 de riesgo indeterminado. Diez pacientes fallecieron por progresión de la enfermedad y 13 pacientes presentaron metástasis a distancia.Conclusiones: en nuestra serie, tal como en la literatura, se observa un predominio del sexo masculino y mayor frecuencia de localización gástrica. La supervivencia fue del 42% a los 5 años. La aplicación de los criterios de Fletcher fue consistente con la evolución. ABSTRACTBackground: gastrointestinal stromal tumors (GISTs) are rare (10 to 20/million). They exist in the whole digestive system and its surroundings, and are most common in the stomach (70%), followed by the small intestine (20-25%), colon and rectum (5%), and esophagus (< 5%). Their clinical presentation varies from small, incidentally found nodules to large and aggressive tumors. Nowadays GISTs are classified according to Fletcher's classification.Objective: to review the features of our GIST population. Methods: a retrospective study of GIST patients identified by immunohistochemical criteria, from 1997 to December 2007, and classified according to Fletcher's criteria.Results: 43 patients were included (24 men, 19 women) with a mean age of 62.7 years. Gastric GISTs (20 cases, 46.5%), small intestine GISTs (18 cases, 41.9%); in 5 cases metastases of occult tumors were found. Eighteen cases had no symptoms. Tumors were classified according to Fletcher's criteria as high-risk (n = 19), intermediate-risk (n = 7), low-risk (n = 12), and indeterminate-risk (n = 5). Death occurred in 10 patients, and 13 patients had metastatic disease.Conclusions: our results are in accordance with the world literature, in which a majority of cases are men with gastric tumors. The 5-year survival rate was 42%. Fletcher's criteria were easily applicable criteria and could predict tu...

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Gastrointestinal stromal tumor

Cited by 66 publications

References 80 publications

Gastrointestinal Stromal Tumours: Review of 150 Cases from a Single Centre

Gastrointestinal Stromal Tumours: Review of 150 Cases from a Single Centre

Proximal Jejunal Gastrointestinal Stromal Tumor And Emergency Surgery: A Case Report

Tumores del estroma gastrointestinal: Estudio retrospectivo de 43 casos

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