Gastroprotective activity of<i>Nigella sativa</i>L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats

Kanter, Mehmet; Demır, Halit; Karakaya, Cengiz; Özbek, Hanefí

doi:10.3748/wjg.v11.i42.6662

Cited by 167 publications

(106 citation statements)

References 28 publications

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“…In fact, N. sativa attenuates the damage to β-cells of the pancreas following exposure to toxic elements such as cadmium [9] . Similarly, N. sativa administration attenuates the ulcerative effects of ethanol on gastric mucosa by decreasing the glutathione-S transferase levels in gastric mucosa [10] . Besides these effects, N. sativa also demonstrates antiparasitic effects.…”

Section: To the Editormentioning

confidence: 99%

Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

Kapoor¹

2009

WJG

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Nigella sativa (N. sativa ) decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa. N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride.

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Section: To the Editormentioning

confidence: 99%

Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

Kapoor¹

2009

WJG

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“…A previous study reported that TQ could protect gastric mucosa from acute alcohol-induced mucosal injury, and that this gastroprotective effect might be induced by its radical-scavenging activity. [26] In addition, hepatoprotective effects of TQ against several hepatotoxic agents have been reported, which were attributed to its antioxidant activity. [27][28][29] It was also reported that TQ could be used to treat ethanol-induced hepatotoxicity because of its antioxidant and anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study

Gülşen

Ak²,

Kara³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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“…Several experimental evidences proved that the herbs have gastro protective activities against gastric mucosal injury induced by ethanol 21 , ischemia reperfusion 22 , indomethacin 21 , alcohol toxicity 23 or stress 24 in rat. Herb-induced gastro protection mechanism varies according to the nature and chemical constituents of the herbs.…”

Section: Herbal Treatment For Peptic Ulcermentioning

confidence: 99%

Complementary and Alternative Approaches to Treat Peptic Ulcer

Sultana¹,

Akram²,

Muhammad³

et al. 2014

Int. Res. J. Pharm.

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Peptic ulcer is considered as one of the most common disorder among gastrointestinal ailments all over the world which is mainly caused by Helicobacter pylori infection, abundant use of NSAIDs, excessive alcohol intake and stress etc. Treatment of peptic ulcer with synthetic drugs such as proton pump inhibitors, H2 receptor antagonists and other non-steroidal anti-inflammatory drugs reported to have adverse effects, relapses and drug interactions. Medicinal plants containing active phyto-constituents have been proven as useful source in the prevention and treatment of various diseases including gastrointestinal problems. Demands of herbal medicines are increasing in both developed and developing countries due to growing recognition of natural plants having lesser or no side effects, relatively less toxic, economical and easily available in surrounding place. Therefore, medicinal plants stand out as being exceptional for its ethnic, ethno botanical and ethno pharmaceutical uses. In this review an attempt has been made to compile some plants which may be used in treatment or prevention of peptic ulcers. This article summarizes the antacid, anti-ulcer and gastro protective properties of the most commonly available medicinal plants.

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Gastroprotective activity ofNigella sativaL oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats

Abstract: Both NS and TQ, particularly NS can partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects might be induced, at least partly by their radical scavenging activity.

Cited by 167 publications

References 28 publications

Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study

Complementary and Alternative Approaches to Treat Peptic Ulcer

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