Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats

El‐Abhar, Hanan S.; Abdallah, Dalaal M.; Saleh, S. A.

doi:10.1016/s0378-8741(02)00324-0

Cited by 158 publications

(95 citation statements)

References 18 publications

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“…3 and 4. This was consistent with the previous findings that N. sativa oil increases glutathione (GSH) and SOD [42]. C. longa protects against ischemia-induced changes by increasing the antioxidant defense mechanisms [43].…”

Section: Discussionsupporting

confidence: 93%

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Roopha¹,

Padmalatha²

2011

J. Med. Toxicol.

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Cadmium is one of the elements found to damage antioxidant systems in mammals. To ameliorate cadmium toxicity and to prevent oxidative stress, natural products may be useful. In Indian ethnobotanical practice, a mixture of 17 herbal products is used to fortify the reproductive system of women after parturition and to reverse ovarian oxidative stress. Oral administration of this extract to rats exposed to cadmium was useful in reversing oxidative stress. Two different doses of cadmium (50 ppm and 200 ppm) were given to Wistar rats aged 45 and 65 days. An herbal extract derived from 17 plants was administered orally every day at a dose level of 200 mg/kg of body weight to the rats exposed to cadmium. A battery of enzymes involved in antioxidant activity in the ovary, including superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione-s-transferase (GST) were measured in the control, cadmium-exposed rats without treatment and in the cadmium-exposed rats treated with herbal extract. The reduction in SOD, catalase, GPx and GST activity after cadmium exposure improved significantly in the rats treated with the herbal extract (p<0.05). The decrease of antioxidant enzymes due to cadmium exposure was reversed significantly with herbal extract administration. The synergistic effect of each bioactive compound in different herbal extracts requires further study.

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Section: Discussionsupporting

confidence: 93%

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Roopha¹,

Padmalatha²

2011

J. Med. Toxicol.

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“…These biochemical changes were accompanied by an increase in the formation of gastric lesions, which was reduced by either treatment. This indicates that both NSO and TQ possess gastroprotective effect against gastric lesions which may be related to the conservation of the gastric mucosal redox state [82] . N. sativa prevents alcohol induced increase in lipid peroxidation (i.e.…”

Section: Gastro-protective Activitymentioning

confidence: 83%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,117

796

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“…Several experimental evidences proved that the herbs have gastro protective activities against gastric mucosal injury induced by ethanol 21 , ischemia reperfusion 22 , indomethacin 21 , alcohol toxicity 23 or stress 24 in rat. Herb-induced gastro protection mechanism varies according to the nature and chemical constituents of the herbs.…”

Section: Herbal Treatment For Peptic Ulcermentioning

confidence: 99%

Complementary and Alternative Approaches to Treat Peptic Ulcer

Sultana¹,

Akram²,

Muhammad³

et al. 2014

Int. Res. J. Pharm.

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Peptic ulcer is considered as one of the most common disorder among gastrointestinal ailments all over the world which is mainly caused by Helicobacter pylori infection, abundant use of NSAIDs, excessive alcohol intake and stress etc. Treatment of peptic ulcer with synthetic drugs such as proton pump inhibitors, H2 receptor antagonists and other non-steroidal anti-inflammatory drugs reported to have adverse effects, relapses and drug interactions. Medicinal plants containing active phyto-constituents have been proven as useful source in the prevention and treatment of various diseases including gastrointestinal problems. Demands of herbal medicines are increasing in both developed and developing countries due to growing recognition of natural plants having lesser or no side effects, relatively less toxic, economical and easily available in surrounding place. Therefore, medicinal plants stand out as being exceptional for its ethnic, ethno botanical and ethno pharmaceutical uses. In this review an attempt has been made to compile some plants which may be used in treatment or prevention of peptic ulcers. This article summarizes the antacid, anti-ulcer and gastro protective properties of the most commonly available medicinal plants.

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Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats

Cited by 158 publications

References 18 publications

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

A review on therapeutic potential of Nigella sativa: A miracle herb

Complementary and Alternative Approaches to Treat Peptic Ulcer

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