Gastroprotective effect of Achyranthes aspera Linn. leaf on rats

Das, Ashish K; Bigoniya, Papiya; Verma, Neelesh Kumar; Rana, Ajay

doi:10.1016/s1995-7645(12)60024-8

Cited by 25 publications

(15 citation statements)

References 19 publications

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“…Peptic ulcer usually occurs in the stomach and duodenum and affects a considerable number of people in the world (De Lacerda Neto et al, ; Sagradas et al, ). This pathology is developed when the balance between offensive (acid, pepsin, Helicobacter pylori ) and defensive factors (mucus, bicarbonate, prostaglandins, blood flow) is lost (Das, Bigoniya, Verma, & Rana, ). The imbalance between gastroprotective and aggressive agents may be caused by stress, smoking, nutritional deficiencies, and excessive ingestion of nonsteroidal anti‐inflammatory drugs (NSAIDs) (Berenguer et al, ).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

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This study was designed to investigate the antioxidant and antiulcer activities of flavonoid‐rich fractions of Zingiber officinale extract. The fractions, obtained by solvents of increasing polarities, were subjected to 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity. The fraction which possessed the highest antioxidant activity was used to assess gastroprotective action against diclofenac sodium induced gastric ulcer in rats. Chromatographic profiling was carried out using LC‐ESI‐MS analysis. The butanol fraction (BF) showed the strongest antioxidant potential and the results of the in vivo study revealed that BF at 100 mg/kg protected against gastric lesions. At the same dose, BF prevented diclofenac sodium‐induced increase in tumor necrosis factor alpha (TNF‐α) and malondialdehyde (MDA) levels, and depletion of catalase (CAT) activity as well as glutathione (GSH) and prostaglandin E2 (PGE2) contents. LC‐ESI‐MS analysis revealed the presence of 12 phenolic compounds. BF exerted antiulcer action which could be linked to the presence of phenolic compounds. Practical applications Zingiber officinale has been widely consumed as a spice and used in folk medicine for treatment of gastric disorders. This is the first report evaluating the pharmacological effects of the butanol extract of ginger for the prevention of gastric ulcer. The results showed that the extract affords better gastroprotective activity against diclofenac sodium‐induced gastric ulcer in rats by reducing oxidative stress. Information provided in this study will be beneficial for developing applications of ginger in food biotechnology as functional and nutraceutical ingredient.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

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“…They are also used as an antidote for snake bites (Siddiqui & Husain, 1990) and cure for women as well as child diseases (Borthakur, 1992), venereal diseases (Hamill et al, 2003), malarial fever, asthma, hypertension and pneumonia (Vasudeva & Sharma, 2006). This ethanomedicinal herb is also reported to have many pronounced activities including hepatoprotective, cancer chemopreventive, anti-inflammatory, anti-arthritic, thyroid-stimulating, anti-peroxidative, reproductive function stimulative, immunomodulatory, wound healing, antioxidant (Edwin et al, 2008), gastroprotective (Das et al, 2012), vaginal contraceptive (Paul et al, 2010) and anxiolytic (Barua et al, 2012) activities. Beneficial effects of this herb are reported to extend to oral hygiene maintenance and caries prevention by folkloric tradition in many parts of India including Dharwad district of Karnataka (Hebbar et al, 2004) and in parts of Tamil Nadu, southern India, where in number of villages, people use its stem and root as teeth cleaning natural toothbrush.…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm and quorum sensing inhibitory activity ofAchyranthes asperaon cariogenicStreptococcus mutans: Anin vitroandin silicostudy

Murugan

Sekar

Sangeetha

et al. 2013

Pharmaceutical Biology

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“…Ethanol rapidly penetrates the gastric mucosa, causing damage to the membrane, exfoliating the cells, and leading to tissue erosion [14] via mechanisms such as the formation of reactive oxygen species (ROS) [78], a decrease in the concentrations of SH in the contents of the gastric mucosa [79], rupture of the endogenous mucus and increase in gastric acid secretion, and damage to the gastric mucosa due to hemorrhagic lesions [80], cellular apoptosis [81], induction of lipid peroxidation, and decreased levels of GSH [82]. Ethanol also induces injury to the vascular endothelium of the mucosa, causing disorders in the microcirculation and promoting ischemia, resulting in an imbalance with substantial production of free radicals at the site [83].…”

Section: Ethanolmentioning

confidence: 99%

Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

et al. 2020

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Peptic ulcer disease (PUD) is a multifactorial and complex disease caused by an imbalance of protective and aggressive factors (endogenous and exogenous). Despite advances in recent years, it is still responsible for substantial mortality and triggering clinical problems. Over the last decades, the understanding of PUD has changed a lot with the discovery of Helicobacter pylori infection. However, this disease continues to be a challenge due to side-effects, incidence of relapse from use of various anti-ulcer medicines, and the rapid appearance of antimicrobial resistance with current H. pylori therapies. Consequently, there is the need to identify more effective and safe anti-ulcer agents. The search for new therapies with natural products is a viable alternative and has been encouraged. The literature reports the importance of monoterpenes based on the extensive pharmacological action of this class, including wound healing and anti-ulcerogenic agents. In the present study, 20 monoterpenes with anti-ulcerogenic properties were evaluated by assessing recent in vitro and in vivo studies. Here, we review the anti-ulcer effects of monoterpenes against ulcerogenic factors such as ethanol, nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori, highlighting challenges in the field.Biomolecules 2020, 10, 265 2 of 18 PUD results from an imbalance in mucosal defensive factors, such as mucus secretion, bicarbonate efflux, endogenous antioxidant, cell regeneration, continuous synthesis and release of prostaglandin E 2 (PGE 2 ), nitric oxide (NO), and sulfhydryl compounds (SH); and aggressive agents such as smoking, alcohol consumption, dietary factors, stress, prolonged and excessive intake of nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori (H. pylori) infection, among others [6][7][8][9]. For a long time, it was believed that the main factor implicated in the development and progression of peptic ulceration was an hypersecretory acidic environment and together with dietary factors and/or stress was thought to cause most of PUD. But the discovery of H. pylori infection and the widespread use of NSAIDs in the second half of the 20 th century changed this perception. In recent years, peptic ulcer has been found to have multiple causes-H. pylori infection, NSAIDs, smoking, alcohol consumption, stress, lifestyle, and genetic predispositions are determined as major risk factors for the development of PUD [2]. PathophysiologyUnder normal conditions, gastric and duodenal mucosa integrity is maintained by the mucus-bicarbonate barrier, the neutral pH, and continuous epithelial cell renewal [10,11]. PGE 2 stimulates cell proliferation, mucus, and bicarbonate production, promoting a crucial function in mucosa preservation. Another vital factor in gastric homeostasis is adequate blood flow. The NO and PGs are responsible for the maintenance of proper perfusion to the gastric mucosa, assuring the delivery of oxygen and nutrients, as well as removing toxic metabolites, preventing damages to the ti...

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Gastroprotective effect of Achyranthes aspera Linn. leaf on rats

Abstract: The results of this study show significant gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids, saponins and tannins.

Cited by 25 publications

References 19 publications

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Antibiofilm and quorum sensing inhibitory activity ofAchyranthes asperaon cariogenicStreptococcus mutans: Anin vitroandin silicostudy

Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

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