Gastroprotective effects of plants extracts: Acacia catechu on gastric mucosal injury in experimental albino rats model

Abstract

Background: Around the globe acid peptic disease and its potential complications are among the major cause of morbidity and is a significant burden on health system. Till now the main stay of treatment are the pharmaceutical agents which decrease the secretion of acid. But these have potential complications and tolerability issues. Among such plants one is Acacia catechu commonly available in India and Pakistan.Methods: This experimental study involved 48 albino rats that were divided into four groups. Group A, B, C, and D were given water, 100mg aspirin, 100 mg aspirin+ 250 mg Acacia catechu and 100 mg aspirin+500 mg Aacacia catechu respectively, and were sacrificed on day 3, 7 and 14th day of study and observed for changes.Results: Difference between blood vessels in subgroup B1 and subgroup C1 with subgroup D1 was statistically significant (p=0.05) and (p=0.001). Group C1 and D1 had normal vessels in mucosa and submucosa. However, dilatation of blood vessels was noted in both groups receiving Acacia catechu along with ASA.Conclusions: Aqueous extracts of Acacia catechu stem and bark showed significant anti-ulcer and anti-inflammatory activities by increasing blood flow to the stomach.

Characterizing the Bioactive Role of Selected Components with Neuroprotective Properties of Two Ethnomedicinal Plants-Acacia catechu and Ficus religiosa

“…12,18,19 Further, under in vivo conditions, these groups stabilize the enzymes involved in the anti-inflammatory pathway and reduce the progression of inflammation. 8,9,20 The flavonoid-rich fraction of AC and a saponin-rich fraction of FR show a remarkable inhibition of protein denaturation. This further delineates the prominent role of flavonoid and saponin components responsible for most of the anti-inflammatory properties of AC and FR.…”

“…Khair has historically been helpful for treating leprosy and numerous gastrointestinal disorders. 8,9 Furthermore, the leaf extract has been shown to possess antioxidant and anti-cholinesterase activity. 10 In addition, the Heartwood extracts have been shown to possess antioxidant, anti-inflammatory, and neuroprotective Properties.…”

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

“…Different parts of this plant extracts were reported with antidiarrheal [37], antihyperglycemic [19,30,[38][39][40], antimicrobial [21], anti-inflammatory [41], antipyretic [42], antioxidant [43,44], antiulcer [45], hepatoprotective [27,46], and immunomodulatory [17] activity. Additionally, Acacia species extracts also show antiviral activity against dengue virus [47,48], human immunodeficiency virus (HIV) [49,50], herpes simplex virus [49], and hepatitis B and C virus [51,52].…”

“…Patel et al highlight the high contents of catechin and epicatechin which are responsible for antibacterial activity [9]. Additionally, taxifolin (51) isolated from leaves extracts showed an inhibitory effect against Streptococcus mutans HO OH Gallocatechin (36) Procyanidin B1 (38) Emodin (40) Maclurin (41) Naringenin ( 43) Irisflorentin (42) Epigallocatechin (37) Chrysin (46) Procyanidin B3 (39) Diosmetin ( 45)…”