Gastroprotective effects of the essential oil of Hyptis crenata Pohl ex Benth. on gastric ulcer models

Diniz, Lúcio Ricardo Leite; Vieira, Charliene Freire Xavier; Santos, Edgleyson C.; Lima, Glauber Cruz; Aragão, Kalynca Kayla Viana; Vasconcelos, Raimundo Pereira de; Araújo, Pâmella Cristina da Costa; Vasconcelos, Yuri; Oliveira, Ariclécio Cunha de; Oliveira, Hermógenes David de; Portella, Viviane Gomes; Coelho‐de‐Souza, Andrelina Noronha

doi:10.1016/j.jep.2013.07.026

Cited by 25 publications

(12 citation statements)

References 25 publications

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“…In final years, experimental studies have reported the gastroprotective effect of some Hyptis species, supporting their popular use for treatment of gastrointestinal disturbances in traditional medicine from different countries, including Brazilian folk medicine. [ 15 16 17 18 19 20 21 ] In addition, the presence of α-pinene has been reported in diverse Hyptis plant species,[ 14 ] suggesting a possible relation between α-pinene and gastroprotection. In this context, we have investigated the relation between inhibition of ethanol-induced gastric lesion (%) produced by oral treatment of essential oil obtained from different Hyptis species (100 mg/kg) and their concentrations of α-pinene (%), respectively.…”

Section: Discussionmentioning

confidence: 99%

“…[ 15 16 17 18 19 20 ] As illustrated in Figure 3 , it was observed the following relation: H. martiussi (3.5%:47.1%), Hyptis suaveolens (8.5%:58.0%), H. crenata (13.4%:68.0%) and H. spicigera (50.8%:97.1%). [ 15 16 17 18 19 20 ] These relations have provided significant Pearson and linear correlations (Pearson coefficient = 0.9758; R 2 =0.9523; P < 0.05) between magnitude of α-pinene concentration and gastroprotective effects of Hyptis species.…”

Section: Discussionmentioning

confidence: 99%

“…In order to evaluate the correlation between α-pinene concentrations and gastrotropective effects of essential oils obtained from Hyptis species, the relation between both parameters of four Hyptis species was analyzed by Pearson correlation and linear regression tests. It was evaluated the correlation between α-pinene concentrations (%) and the effect of oral treatment, at dose of 100 mg/kg, of essential oils obtained from H. martiussi ,[ 15 ] H. suaveolens ,[ 16 17 ] H. spicigera [ 19 ] and H. crenata [ 20 ] on inhibition of ethanol-induced gastric lesion area (%).…”

Section: Methodsmentioning

confidence: 99%

“…[ 15 16 17 18 19 ] In recent times, our group showed that the essential oil obtained from aerial parts of H. crenata reduced the rat gastric mucosa lesions and increased the mucus production and the gastriointestinal emptying. [ 20 ] These results suggest that the genus Hyptis (lamiaceae), comprised for more than 300 species widespread in tropical and temperate regions of America,[ 21 ] might be an interesting natural source of novel gastroprotective agents.…”

Section: Introductionmentioning

confidence: 99%

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Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species

et al. 2015

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Background:Alpha-pinene (α-pinene) is a monoterpene commonly found in essential oils with gastroprotective activity obtained from diverse medicinal plants, including Hyptis species. The genus Hyptis (lamiaceae) consists of almost 400 species widespread in tropical and temperate regions of America. In the north and northeastern Brazil, some Hyptis species are used in traditional medicine to treat gastrointestinal disturbances.Objective:The present study has investigated the gastoprotective effect of purified α-pinene in experimental gastric ulcer induced by ethanol and indomethacin in mice.Materials and Methods:Gastric ulcers were induced in male Swiss mice (20-30 g) by oral administration of absolute ethanol or indomethacin 45 min after oral pretreatment with vehicle, standard control drugs or α-pinene (10, 30, and 100 mg/kg). One hour after the ulcerative challenges, the stomach were removed, and gastric lesions areas measured. The effects of α-pinene on the gastric juice acidity were determined by pylorus ligation model. The gastrointestinal motility and mucus depletion were determined by measuring the gastric levels of phenol red and alcian blue, respectively. Hematoxylin and eosin stained sections of gastric mucosa of the experimental groups were used for histology analysis.Results:α-pinene pretreatment inhibited ethanol-induced gastric lesions, reduced volume and acidity of the gastric juice and increased gastric wall mucus (P < 0.05). Furthermore, we showed an interesting correlation between concentration of α-pinene and gastroprotective effect of Hyptis species (P Pearson = 0.98).Conclusion:Our data showed that the α-pinene exhibited significant antiulcerogenic activity and a great correlation between concentration of α-pinene and gastroprotective effect of Hyptis species was also observed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species

et al. 2015

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“…In a study recently described by Diniz et al [34], the essential oil of H. crenata Pohl ex Benth. promoted a significant inhibition of gastric lesions induced by ethanol or indomethacin, as well as it has produced a decrease in lipid peroxidation.…”

Section: Discussionmentioning

confidence: 95%

Gastroprotective and Ulcer Healing Effects of Essential Oil of Hyptis martiusii Benth. (Lamiaceae)

et al. 2014

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Hyptis martiusii Benth. is an aromatic plant found in abundance in northeastern Brazil that is used in ethnomedicine to treat gastric disorders. The aim of this study was to elucidate the mechanisms of action involved in the gastroprotection of the essential oil of Hyptis martiusii (EOHM) and to evaluate its healing capacity. Wistar rats were exposed to different protocols and subsequently were treated with 1% Tween-80 aqueous solution (negative control), pantoprazole, carbenoxolone, N-acetylcysteine (depending on the specificity of each model) or EOHM. The antisecretory activity (basal or stimulated) was determined using the pyloric ligature method. The gastroprotective action of nitric oxide and sulphydryl groups (–SH groups), as well as the quantification of adherent mucus and the levels of malondialdehyde and –SH groups in gastric mucosa, were evaluated using ethanol-induced gastric ulcer model. The healing ability was evaluated using the acetic acid-induced gastric ulcer model and histological and immunohistochemical analysis (HE, PAS and PCNA). EOHM (400 mg/kg) reduced the volume and acidity of gastric secretion stimulated by histamine and pentagastrin. The gastroprotective effect of EOHM involves the participation of endogenous sulfhydryl groups. EOHM increased mucus production (54.8%), reduced levels of MDA (72.5%) and prevented the depletion of –SH groups (73.8%) in the gastric mucosa. The treatment with EOHM reduced in 70.3% the gastric lesion area, promoting significant regeneration of the gastric mucosa, as confirmed by histological analysis and analysis of proliferating cell nuclear antigen. The results show that gastroprotective effect of EOHM is mediated by cytoprotective and antioxidant mechanisms and by their antisecretory activity, and suggest that the essential oil of Hyptis martiusii is a promising candidate for the treatment of gastric ulcers.

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A review of the phytochemical profiling and biological activities of Hyptis Jacq.: a Brazilian native genus of Lamiaceae

et al. 2020

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Hyptis Jacq. (Lamiaceae) has been used in traditional medicine for the treatment of many diseases around the world. However, Harley and Pastore in 2012 proposed a new circumscription for this large genus, reducing its number of species, but supporting its monophyly. Hyptis and Peltodon were used as keywords, and triage of articles was performed using genus delimitation sensu Harley and Pastore. Only 29 species have some type of record in the literature for their medicinal use and chemical description, corresponding to 20% of the 148 species. Most cited biological activities were the antioxidant activity, reported for 9% of the species, and the antifungal activity reported for 5% of the species. For 11% of the species was described the essential oil composition, while non-volatile compounds were reported for only 6% of them. Terpenes, flavonoids, and caffeic acid derivatives are the most reported compounds for this genus. Only 8% of the species are reported as medicinal, with potential as antibacterial and antiparasitic, pointing to relevance of Hyptis to bioprospecting studies, especially in South America and Africa. However, there is a lack of studies regarding isolated compounds concerning their toxicology and efficacy, important information to achieve the production and the effective use of Hyptis as a herbal medicine.

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Gastroprotective effects of the essential oil of Hyptis crenata Pohl ex Benth. on gastric ulcer models

Cited by 25 publications

References 25 publications

Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species

Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species

Gastroprotective and Ulcer Healing Effects of Essential Oil of Hyptis martiusii Benth. (Lamiaceae)

A review of the phytochemical profiling and biological activities of Hyptis Jacq.: a Brazilian native genus of Lamiaceae

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