Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities

Chiral N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Stable Enols: A Highly Enantioselective Coates–Claisen Rearrangement

“…49, 50 We have also conducted extensive investigations into the reaction mechanism and confirmed that the reaction occurs via a Claisen-type rearrangement in our cases 51, 52 rather than a 1,4-addition of the enol to the catalytically generated α,β -unsaturated acyl azolium. 53, 54 Furthermore, our elucidated mechanism suggested that the Claisen rearrangement on the hemiacetal intermediate ( II ) should be the stereochemically determining step.…”

Studies on the regio- and diastereo-selective epoxidation of daphnanes and tiglianes

“…2 Only recently, however, have scientists begun to structurally characterize the active compounds and elucidate their molecular modes of action. Representative members of these families (Figure 1) include the phorbol esters, yuanhuapin, 3,4 gnidimacrin, 5 and rediocide A 6 which, along with many other family members, have emerged as significant therapeutic leads and research tools. 1 The phorbol esters, for example, are the most studied and potent tumor promoters known 7 while prostratin, 12-deoxy-phorbol 13-acetate, is a preclinical lead in studies directed at an as yet unattained but hugely important goal, the eradication of HIV/AIDS.…”

Plants as Potential Sources of Pesticidal Agents: A Review

“…For the first time three compounds possessing the daphnane orthoester skeleton, which are constituents of the ethyl acetate extract of E. agallocha, were found to be insecticidal [18][19]. The pawpaw tree, Asimina tribola (Annonaceae), a plant found in various traditional communities, particularly in Africa and the Americas, has been investigated and found to possess antitumor, pesticidal, and anti-feedant properties.…”