GC–MS analysis of breath odor compounds in liver patients

Velde, Sandra Van den; Nevens, Frederik; hee, Paul Van; Steenberghe, Daniël van; Quirynen, Marc

doi:10.1016/j.jchromb.2008.08.031

Cited by 226 publications

(184 citation statements)

References 20 publications

(33 reference statements)

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“…Furthermore, they present themselves as endogenous products of physiological/metabolic body processes or products of various microbial pathogens/commensals, or they are produced by the host in response to microbial infections, e.g., during the inflammatory response. It is believed that VOCs are transported from different organs via blood to the lungs and subsequently excreted from there by diffusing across the pulmonary alveolar membrane and exhaled via breath (25). Assessment of endogenous VOCs can provide insights into healthy and diseased metabolic states, whereas the detection of exogenous compounds suggests exposure to a drug or compound associated with environmental or occupational exposure (26).…”

mentioning

confidence: 99%

Clinical Application of Volatile Organic Compound Analysis for Detecting Infectious Diseases

2013

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SUMMARY This review article introduces the significance of testing of volatile organic compounds (VOCs) in clinical samples and summarizes important features of some of the technologies. Compared to other human diseases such as cancer, studies on VOC analysis in cases of infectious diseases are limited. Here, we have described results of studies which have used some of the appropriate technologies to evaluate VOC biomarkers and biomarker profiles associated with infections. The publications reviewed include important infections of the respiratory tract, gastrointestinal tract, urinary tract, and nasal cavity. The results highlight the use of VOC biomarker profiles resulting from certain infectious diseases in discriminating between infected and healthy subjects. Infection-related VOC profiles measured in exhaled breath as well as from headspaces of feces or urine samples are a source of information with respect to disease detection. The volatiles emitted in clinical matrices may on the one hand represent metabolites of the infecting pathogen or on the other hand reflect pathogen-induced host responses or, indeed, a combination of both. Because exhaled-breath samples are easy to collect and online instruments are commercially available, VOC analysis in exhaled breath appears to be a promising tool for noninvasive detection and monitoring of infectious diseases.

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confidence: 99%

Clinical Application of Volatile Organic Compound Analysis for Detecting Infectious Diseases

2013

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“…It used for differentiating and quantifying the VSC and also distinguish other classes of compound Drawbacks of traditional laboratory methods are -cumbersome, need inert column carrier gas (gas cylinders of nitrogen or helium) and require technicians with adequate training. Recently, trailblazing research was performed by van den Velde et al 14,15 with gas chromatography-mass spectrometry as a tool for differential diagnosis of halitosis, with the possibility to detect extra-oral causes, which often remain undetected unless characterized by a specific smell.…”

Section: Gas Chromatographymentioning

confidence: 99%

Halitosis-An Update

Kalsi¹,

Mathur²,

Gill³

et al. 2017

IOSR JDMS

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“…It follows that the application of interdigitated electrode arrays (IDAs) can also exploited to further miniaturise sensing systems often through the incorporation of nanocomposites, Liu et al [97] describes the detection of volatile sulphur compounds (associated with a variety of ailments [98][99][100]) in a subject's breath exhalations. The authors report that the fabricated PANI/AuNPs sensor electrodes exhibited a good response to both H2S (1.0 ppm) and CH3SH (1.5 ppm) gases and that in comparison with other sensors, these novel IDA electrodes possess a greater selectivity and sensitivity while also being low cost.…”

Section: Miniaturisationmentioning

confidence: 99%