GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats

Soumya, V; Muzib, Y. Indira; Venkatesh, P; Hariprasath, K.

doi:10.1016/s1875-5364(14)60103-5

Cited by 23 publications

(16 citation statements)

References 21 publications

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“…showed significant recovery from cystic ovaries which is further confirmed by its histopathological studies. It has been reported that plants Cocos nucifera ,[ 11 ] A. barbadensis ,[ 12 ] and Labisia pumila [ 20 ] showed a similar effect in PCOD-induced rats.…”

Section: Discussionmentioning

confidence: 95%

“…[ 9 ] It has been reported that free radicals set up a chain of biochemical reactions which lead to the formation of many highly reactive intermediates and that affects the process of fertilization and implantation in uterus. [ 11 ] In the ovaries, this increased oxidative stress may leads to the loss of gonadotropin receptors and normal ovarian functions. This study could not compare the results with a standard drug because there is no single drug available for the treatment of PCOD as it involves multidrug therapy.…”

Section: Discussionmentioning

confidence: 99%

“…During the study, the estrus cycles were monitored regularly by vaginal smear method. [ 11 ] After the conclusion of the study, rats were sacrificed by decapitation, and blood samples were collected. The reproductive system was separated and preserved.…”

Section: Methodsmentioning

confidence: 99%

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A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease

2016

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Objective:To evaluate the potential effect of bamboo seed oil in decreasing the major metabolic symptoms associated with letrozole-induced polycystic ovarian disease using female rat model.Materials and Methods:A new method of microwave-assisted extraction was developed. Female rats were grouped into four with six animals each. All rats were daily administered with letrozole (1 mg/kg b.wt.) for 21 days except control, and during this period, changes in estrous cycle were observed. After letrozole treatment, Group 2 was considered negative control, Groups 3 and 4 were treated orally with bamboo oil, 0.5 ml/kg b.wt. and 1 ml/kg b.wt., respectively, for 3 weeks (five consecutive estrus cycles). Various parameters such as estrus cycle, blood sugar level, lipid profile, and weights of reproductive system were determined. The characteristics of cystic ovaries were evaluated by histopathological studies.Results:The isolated bamboo oil restored estrus cyclicity showed hypoglycemic and hypolipidemic effects. 1 ml/kg b.wt. of bamboo oil showed a marked glucose reduction from 254.04 ± 2.08 to 92.6 ± 1.63, and levels of total cholesterol, very low-density lipoprotein, triglyceride were reduced from 186.45 ± 2.28, 30.07 ± 2.36, 100.36 ± 2.35 to 152.14 ± 2.63, 25.94 ± 1.66, 93.32 ± 1.09, respectively. Histopathological results showed the presence of ovulation and recovery from cystic ovaries.Conclusion:A novel and promising drug was isolated in the treatment and maintenance of various metabolic symptoms associated with polycystic ovary disease.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease

2016

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“…Different products from the coconut plant have been studied extensively for their medicinal properties (Roopan 2016). Research has demonstrated the presence of metabolites such as polyphenols, glycosides, steroids, alkaloids, terpenoids, and others which could be responsible for those activities (Renjith et al 2013;Manalo et al 2017;Oliveira et al 2009;Singla et al 2011;Soumya et al 2014). More specifically, the husk extracts of C. nucifera have shown to have antimalarial properties when tested in vitro and in vivo (Adebayo et al 2012;Adebayo et al 2013;Balogun et al 2014;Angeles et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice

Tayler

Jesús

Spadafora³

et al. 2020

J Parasit Dis

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Plasmodium falciparum (P. falciparum) malaria presents serious public health problems worldwide. The parasites resistance to antimalarial drugs has proven to be a significant hurdle in the search for effective treatments against the disease. For this reason, the study of natural products to find new antimalarials remains a crucial step in the fight against malaria. In this study, we aimed to study the in vivo performance of the decoction of C. nucifera leaves in P. berghei-infected mice. We analyzed the effectiveness of different routes of administration and the acute toxicity of the extract. Additionally, we determined the suppressive, curative and prophylactic activity of the extract. The results showed that the decoction of leaves of C. nucifera is most effective when administered intramuscularly to mice in comparison to intraperitoneal, subcutaneous and intragastric methods. We also found that organ signs of acute toxicity appear at 2000 mg/kg/day as evidenced by necropsy examination. Additionally, we found that the prophylactic effect of the extract is of 48% inhibition, however, there is no curative effect. Finally, in a 4-day suppressive assay, we found that the extract can inhibit the growth of the parasite by up to 54% at sub-toxic doses when administered intramuscularly.

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“…Matricaria chamomilla L.-treated female Wistar rats showed decreased cysts in ovarian tissue and an increased number of dominant follicles (Zangeneh et al, 2010). Cocos nucifera L. recovered the estrous cycle; reduced TC, very low density cholesterol and TG levels; and increased HDL-C levels (Soumya et al, 2014). Linum usitatissimum L.-treated female SD rats showed increased antral follicles and corpus luteum, a decreased number of cystic follicles, and reduced diameter of antral follicles (Jelodar et al, 2018).…”

Section: Individual Herbal Extractsmentioning

confidence: 99%

Therapeutic Effects and Mechanisms of Herbal Medicines for Treating Polycystic Ovary Syndrome: A Review

2020

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Background: Polycystic ovary syndrome (PCOS) is one of the most common disorders of endocrinology in reproductive-age women. In this study, we reviewed data on the effects and underlying mechanisms of herbal medicines used in the treatment of PCOS in laboratory studies. Methods: Articles published in English up to June 30, 2018 were searched in Medline and EMBASE. We extracted data regarding herbal intervention; target cell (or animal model) usage; method of herbal extraction; route of administration; dosage and periods; and outcomes of the compounds isolated from herbs, individual herbal extracts, and herbal formula decoctions. We summarized the actions and the mechanisms underlying the beneficial effects of herbal medicines on PCOS. Results: A total of 27 studies involving 22 herbal medicines reported their efficacy on PCOS. The herbal interventions in the 27 studies comprised four compounds isolated from herbs (6 studies), nine individual herbal extracts (11 studies), and nine herbal formula decoctions (10 studies). Herbal medicines normalized female hormones, diminished male hormones, recovered the estrous cycle, ameliorated insulin resistance, and improved lipid metabolism in PCOS. The mechanisms underlying the beneficial effects of herbal medicines on PCOS were found to be associated with anti-inflammation, anti-oxidative stress, inhibition of autophagy and/or apoptosis, and ovarian nerve growth factor reduction. Conclusions: Herbal medicines are thought to be promising resources in the development of effective therapeutic agents for PCOS. Further studies that include methodological quality assessment and quantitative synthesis of outcomes are recommended.

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GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats

Cited by 23 publications

References 21 publications

A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease

A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease

Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice

Therapeutic Effects and Mechanisms of Herbal Medicines for Treating Polycystic Ovary Syndrome: A Review

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