Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties

Abstract

Abstracts:Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]·nH2O. The relaxivity (R1) of these complexes was measured, which turned out to be comparable with that of Omniscan ® , a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, 1 H-NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.

A novel Gd3+ DTPA-bisamide complex with high relaxivity as an MRI contrast agent

“…Although current MRI contrast agents have provided important information for clinical diagnosis, most of them used in clinical practice have low relaxation efficiency and lack organ-targeting ability. [3][4][5] In addition, the long-term safety of the current agents has aroused much more attention in recent years. 6 Therefore, it is urgent to develop new MRI contrast agents to improve their relaxation, enhance the target for specific organs or tumours, and reduce the toxic and side effects.…”