Gels Containing MMP Inhibitors Prevent Dental Erosion in situ

Kato, Melissa Thiemi; Leite, Aline L.; Hannas, Angélica Reis; Buzalaf, Marília Afonso Rabelo

doi:10.1177/0022034510363248

Cited by 111 publications

(156 citation statements)

References 30 publications

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“…Pharmacological studies have reported that MMPs activity was reduced by the application of chlorhexidine (CHX) which in turn leads to the arrest of carious lesion 16,17) . Natural products have been used as folk medicine for thousands of years and are promising sources for novel therapeutic agents 18) .…”

Section: Intorductionmentioning

confidence: 99%

In vitro effect of hesperidin on root dentin collagen and de/re-mineralization

et al. 2012

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The aims of this study were to investigate the effects of hesperidin, a citrus flavonoid, on human root dentin demineralization and collagen preservation, and compare it with chlorhexidine and grape seed extract. Specimens were assigned to different treatment groups: hesperidin, chlorhexidine and grape seed extract. Specimens were subjected to pH cycling by demineralization for 14 h, incubation in testing solutions for 2 h and remineralization in presence of bacterial-derived collagenase for 8 h, for 8 days. Calcium release was measured by means of an atomic absorption spectrophotometer, and degraded collagen matrix was investigated by hydroxyproline assay. Specimens were assessed longitudinally with transverse micro-radiography to investigate lesion depth and mineral loss. In hesperidin and grape seed extract groups, demineralization was reduced when the collagen matrix was preserved. The hesperidin group showed the lowest value in lesion depth and mineral loss, indicating that hesperidin inhibited demineralization and probably enhanced remineralization even under fluoride-free conditions.

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Section: Intorductionmentioning

confidence: 99%

In vitro effect of hesperidin on root dentin collagen and de/re-mineralization

et al. 2012

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“…12 To minimize this process, green tea has a significant inhibitory effect on MMPs and dentin demineralization. 15,16,17 The reduced daily exposure to acid may be minimized by the use of metalloproteinase inhibitors, which protect the organic matrix as a barrier to ion diffusion.…”

Section: Introductionmentioning

confidence: 99%

Effect of green tea as a protective measure against dental erosion in coronary dentine

et al. 2016

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Effect of green tea as a protective measure against dental erosion in coronary dentine Abstract: The aim of this study was to evaluate the effect of green tea as a protective measure on eroded dentin. Disks of human coronary dentin were selected based on surface hardness and randomly assigned to 3 groups (n = 10): DW -distilled water, CHX -0.2% chlorhexidine digluconate, and GT -green tea. The disks were allowed to acquire pellicle for 2 hours and were then subjected to 3 cycles per day of demineralization (C 6 H 8 O 7 0.05 M, pH 3.75, 60 s), treatment (DW or CHX or GT, 5 min) and remineralization (artificial saliva, 60 min) over a period of 3 days. Changes in the dentin were determined by loss of surface hardness (%SHL) and mechanical profilometry analysis at the end of each day. Data were analyzed by two-way ANOVA followed by Tukey's test for %SHL and profilometry (p < 0.05). Significant reductions in dentin hardness loss were observed only for the CHX group when compared to the DW group (p < 0.05). However, there was no significant difference between the CHX and GT groups (p > 0.05). A significant difference was observed between DW and GT treatments for wear and roughness measurements (p < 0.05). The green tea extract solution was able to reduce the wear and roughness caused by dentin erosion under the conditions of this study.

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“…14 Studies have demonstrated that the polyphenols contained in certain natural products, such as propolis 8 and green tea, 10,15 may have inhibitory properties against matrix metalloproteinases (MMP) -2 and -9, which could affect the remineralization of artificially demineralized dentin. 10,15 The roots of the Euclea species are rich in naphthoquinones, which may help explain their therapeutic activity, since these compounds have fungicidal, antibacterial, insecticidal, phytotoxic, cytotoxic and anti-carcinogenic properties.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

“…10,15 The roots of the Euclea species are rich in naphthoquinones, which may help explain their therapeutic activity, since these compounds have fungicidal, antibacterial, insecticidal, phytotoxic, cytotoxic and anti-carcinogenic properties.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

“…virtually all extracellular matrix molecules, including native and denatured collagen. 15 An in situ study evaluated the effect of a solution containing 0.61% green tea extract, versus none, in reducing dentin wear by erosion followed by abrasion. The result demonstrated that the solution containing green tea showed a reduction in wear, compared with the control group, for both conditions.…”

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confidence: 99%

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Erosion and abrasion-inhibiting in situ effect of the Euclea natalensis plant of African regions

et al. 2016

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Erosion and abrasion-inhibiting in situ effect of the Euclea natalensis plant of African regionsAbstract: This study evaluated the effect of Euclea natalensis gel on the reduction of erosive wear with or without abrasion, in enamel and dentin. During two five-day experimental crossover phases, volunteers (n = 10) wore palatal devices containing human enamel and dentin blocks (E = 8 and D = 8). The gel was applied in a thin layer in the experimental group, and was not applied in the control group. In the intraoral phase, volunteers used the palatal appliance for 12 h before the gel treatment, and were instructed to start the erosive challenges 6 h after the gel application. Erosion was performed with Coca-Cola ® (for 5 min) 4 times/day. The appliance was then put back into the mouth and was brushed after 30 minutes. After intraoral exposure, the appliances were removed and the specimens were analyzed using profilometry (mean ± SD, μm). The Euclea natalensis gel caused less wear in enamel in the experimental group (EROS = 12.86 ± 1.75 µm; EROS + ABRAS = 12.13 ± 2.12 µm) than in the control group (EROS = 14.12 ± 7.66 µm; EROS + ABRAS = 16.29 ± 10.72 µm); however, the groups did not differ from each other significantly. A statistically significant value was found for erosion and eros + abrasion in dentin (p = 0.001). Euclea natalensis may play a role in the prevention of dentin loss under mild erosive and abrasive conditions. A clinical trial is required to confirm these promising results in a clinical situation.

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Gels Containing MMP Inhibitors Prevent Dental Erosion in situ

Cited by 111 publications

References 30 publications

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

Effect of green tea as a protective measure against dental erosion in coronary dentine

Erosion and abrasion-inhibiting in situ effect of the Euclea natalensis plant of African regions

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