Gemcitabine Delivery and Photodynamic Therapy in Cancer Cells via Porphyrin‐Ethylene‐Based Periodic Mesoporous Organosilica Nanoparticles

Abstract

Gemcitabine hydrochloride is an FDA-approved chemotherapeutic drug used in the treatment of various cancers. Several drawbacks of gemcitabine, including its short in vivo half-life of 8-17 min associated with ar apid excretion by the kidneys and its poor membrane permeability,h ave inspired research on an anodelivery approach. In this study,w er eport ethylene-based periodic mesoporous organosilica nanoparticles (PMOs) for photodynamic therapy and the autonomous delivery of gemcitabine in cancer cells. Porphyrins were used as photosensitizers and were localized in the walls of the PMOs while ah igh loading capacity of gemcitabine was observed in the porous structure. Depending on the nature of the photosensitizer, and its aggregation state, we were able to perform one or two-photon photodynamic therapy.T wo-photon excited photodynamic therapy combinedw ith gemcitabine delivery led to as ynergya nd av ery efficient cancer cell killing.

Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment

“…TPE‐PDT was carried out against breast cancer cells and the nude mice were injected with the nanovectors for photoacoustic imaging. A recent example of synergistic TPE‐PDT with drug delivery was published by Aggad et al using various porphyrin‐ethane bridged PMO NPs (see the example named PS1‐EPMO in Figure a) . The particles had a highly ordered mesostructure ( S BET ≈ 900 m 2 g −1 ), diameters of ≈200 nm (Figure b) and demonstrated gemcitabine (GEM) payloads from 500 to 700 mg of GEM per gram of NPs with a zero leakage behavior without capping the PMO mesopores.…”

Hollow Organosilica Nanoparticles for Drug Delivery

“…No release of drugs was observed in these conditions showing the intense interactions between both of the drugs and the organosilica matrix. The pH was then adjusted to 5.5 (lysosomal pH) to trigger the drug release . The release amount of GEM and MTX were 45 μg.mL −1 and 160 μg.mL −1 respectively (Figure S5), and were sufficient for further studies in cancer cells.…”

Porphyrin‐based bridged silsesquioxane nanoparticles for targeted two‐photon photodynamic therapy of zebrafish xenografted with human tumor

“…TPE is very attractive for nanomedicine applications as it allows a deep penetration of the near‐infrared beam down to 2 cm in tissues and a high spatiotemporal resolution presenting a strong interest for imaging and cancer detection. Importantly, TPE‐PDT has demonstrated a high potential for cancer therapy and particularly for small‐sized tumor treatment.…”