Hollow Organosilica Nanoparticles for Drug Delivery

Abstract

The sol‐gel synthesis of hollow organosilica nanoparticles incorporating amino groups with uniform size are described. These nanoparticles were successfully prepared via a microemulsion method. Then, the hollow nanoparticles were loaded with gemcitabine hydrochloride or methotrexate and studied in MCF‐7 breast cancer cells.

Organic and Inorganic Template Assisted Synthesis of Silica Nanotubes and Evaluation of Its Properties for Drug Targeting

“…In general, the quaternary cationic surfactant like CTAB [17,18] is responsible for forming even surface tubular structures. The micelles predominantly build cylindrical hollow structures in aqueous conditions.…”

Core–Shell Pluronic-Organosilica Nanoparticles with Controlled Polarity and Oxygen Permeability

“…Nowadays, the emergence of nanomedicine 8 , 9 with the strategic design of nanocarriers endowed with multiple functions, including targeting, yearns for transferring this knowledge to the nanoscale. 10 − 14 …”

“…An efficient nanocarrier is required to host high loads of the drug molecule, which largely depends on matching its solvating nanoenvironment to the chemistry of the drug itself. The possibility to tune the chemistry of the nanocarrier is therefore of utmost importance, and organosilanes 22 − 24 have the potential to modify the network of silica nanostructures for this purpose. 15 − 17 Besides controlling the hosting ability of nanocarriers, a pre-requirement for the design of successful nanostructures for nanomedicine is their colloidal stability, 18 also in biological fluids—thus in the presence of large protein concentration.…”

“…To reach this goal, various formulation strategies have been developed with the main aims of optimizing pharmacokinetics and of properly matching the polarity of the specific drugs. Nowadays, the emergence of nanomedicine , with the strategic design of nanocarriers endowed with multiple functions, including targeting, yearns for transferring this knowledge to the nanoscale. − …”

“…An efficient nanocarrier is required to host high loads of the drug molecule, which largely depends on matching its solvating nanoenvironment to the chemistry of the drug itself. The possibility to tune the chemistry of the nanocarrier is therefore of utmost importance, and organosilanes − have the potential to modify the network of silica nanostructures for this purpose. − Besides controlling the hosting ability of nanocarriers, a pre-requirement for the design of successful nanostructures for nanomedicine is their colloidal stability, also in biological fluidsthus in the presence of large protein concentration. , The well-known preparation of core–shell Pluronic-silica “PluS” nanoparticles , has recently demonstrated to yield small, monodisperse, and colloidally and photophysically stable nanoparticles, also in vivo . This type of silica nanoparticles grows templated by micelles of Pluronic F127a triblock copolymer composed of poly­(ethylene glycol) (PEG) and poly­(propylene glycol) (PPO)in acidic water at 30 °C, and exhibits a silica core diameter of ca.…”