Gender differences in chronic major and double depression

Kornstein, Susan G.; Schatzberg, Alan F.; Thase, Michael E.; Yonkers, Kimberly A.; McCullough, James P.; Keitner, Gabor I.; Gelenberg, Alan J.; Ryan, Christine E.; Hess, A.L; Harrison, Wilma; Davis, Sonia M.; Keller, Martin B.

doi:10.1016/s0165-0327(99)00158-5

Cited by 434 publications

(331 citation statements)

References 40 publications

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“…Further studies on patients with depressive disorders testify to a larger prevalence of alcohol and substance abuse in the male gender (Pettinati, Pierce, Wolf, Rukstalis, & O'Brien, 1997;Moscato et eISSN: 2357-1330 Kornstein et al, 1995), but the gender differences in the relationship between alcohol consumption and problems associated to it have not been quantitatively studied to a great extent (Vennucchi & Villani, 2001).…”

Section: Responsibility Of the Conference Organization Committeementioning

confidence: 99%

Gender Differences In Anxiety, Depression And Metacognition

Lenzo¹,

Toffle²,

Tripodi³

et al. 2016

The European Proceedings of Social and Behavioural Sciences

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There are many gender differences relating to mental health issues and they concern all aspects: diagnosis, treatment and incidence. No research has been conducted to evaluates the role of metacognition on the basis of gender and its relation to other psychological constructs. This study had two primary goals. The first was to compare metacognitions by gender. The second goal was to explore the relations among the constructs of metacognitions, anxiety, depression, pathological worry, and obsessive-compulsive symptoms in two groups. Sixty-four participants (32 men and 32 women) took part in this study; they were assessed with the MCQ-30, STAI, BDI, PSWQ, and PADUA Inventory. T-test results for two independent samples for MCQ-30 did not reveal differences between gender. Results of correlational analysis found significant relations between dysfunctional metacognitive beliefs and other constructs on the basis of gender. In conclusion, results of this study point out that gender differences can play an important role in the clinical efficacy of treatments.

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Section: Responsibility Of the Conference Organization Committeementioning

confidence: 99%

Gender Differences In Anxiety, Depression And Metacognition

Lenzo¹,

Toffle²,

Tripodi³

et al. 2016

The European Proceedings of Social and Behavioural Sciences

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“…Fluoxetine (Prozac®) is frequently prescribed for depression as well as for a variety of other disorders such as premenstrual dysphoria, anxiety, anorexia and bulemia which are more prevalent in females than in males [4,19,22,33]. A reported undesirable side effect of fluoxetine, as well as other selective serotonin reuptake inhibitors (SSRIs), is a high incidence of sexual dysfunction [8,15,28].…”

Section: Introductionmentioning

confidence: 99%

Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior

et al. 2008

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These experiments were designed to evaluate the hypothesis that fluoxetine-induced sexual dysfunction in female rats derived from disruption of neuroendocrine events that normally facilitate sexual behavior. If so, exogenous hormonal priming to ovariectomized rats should eliminate fluoxetine's effect. Ovariectomized rats were subchronically treated with 10 mg/kg fluoxetine or distilled/deionized water vehicle for 9 consecutive days. On the 8 th day of treatment, rats were primed with 10 μg estradiol benzoate followed 48 hr later with 500 μg progesterone. In a pretest for sexual behavior on the 10 th day, there was no difference between subchronic treatments. Sexual receptivity was again monitored 30 min after injection on the 10 th day (acute treatment) with distilled/deionized water, 10 mg/kg fluoxetine or 20 mg/kg fluoxetine. Thereafter, the female's behavior was monitored for 20 min in a male preference procedure. After the acute treatment in rats subchronically treated with water, fluoxetine (10 or 20 mg/kg) significantly reduced both lordosis frequency and quality and reduced (but not significantly) time spent with the male. In rats subchronically treated with fluoxetine, the lordosis-inhibiting effect of an acute injection with fluoxetine was significantly attenuated relative to that of the subchronically water-treated rats. In contrast to expectation, subchronic treatment with fluoxetine increased, rather than reduced, the relative time females spent near the male. Activity, as measured by center crossings, and grooming were also reduced by subchronic treatment with fluoxetine. KeywordsSSRI; sexual motivation; lordosis; subchronic IntroductionFluoxetine (Prozac®) is frequently prescribed for depression as well as for a variety of other disorders such as premenstrual dysphoria, anxiety, anorexia and bulemia which are more prevalent in females than in males [4,19,22,33]. A reported undesirable side effect of fluoxetine, as well as other selective serotonin reuptake inhibitors (SSRIs), is a high incidence of sexual dysfunction [8,15,28]. Although such sexual dysfunction occurs in both genders, more experimental emphasis has been placed on identifying the responsible mechanisms in males than in females [17]. Yet, as much as 32% of female patients may experience SSRI-*Corresponding author Department of Biology, Texas Woman's University, Denton, TX 76204, Phone: 940-898-2356, FAX: 940-898-2382.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. [32]. The mechanisms responsible for such drug-induced sexual dysfunction in females have been difficult to identify,...

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“…3,[14][15][16] Depression is a heterogeneous illness, and two of its subtypes are melancholic depression and atypical depression, see details on Table 1.…”

Section: Melancholic Vs Atypicalmentioning

confidence: 99%

Superposição entre depressão atípica, doença afetiva sazonal e síndrome da fadiga crônica

Juruena

Cleare

2007

Rev. Bras. Psiquiatr.

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Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome Superposição entre depressão atípica, doença afetiva sazonal e síndrome da fadiga crônica A b s t r a c t Objective: We reviewed previous studies that have described an association between abnormal functioning of the hypothalamicpituitary-adrenal axis and depression. In addition to melancholic depression, a spectrum of conditions may be associated with increased and prolonged activation of the hypothalamic-pituitary-adrenal axis. In contrast another group of states is characterized by hypoactivation of the stress system, rather than sustained activation, in which chronically reduced secretion of corticotropin releasing factor may result in pathological hypoarousal and an enhanced hypothalamic-pituitary-adrenal negative feedback. Patients with atypical depression, seasonal affective disorder and chronic fatigue syndrome fall in this category. Method: The literature data on the overlap between the key-words were reviewed, summarized and discussed. Results: Many studies suggest that these conditions themselves overlap biologically, showing hypofunction of central corticotropin releasing factor neuronal systems. Conclusions: Therefore, in the real world of clinical practice, patients often present in a grey area between classical idiopathic fatigue and early chronic atypical depression and/or seasonal depression. This underscores the potential common biological links underpinning commom symptom clusters not only between depression (atypical and seasonal) and chronic fatigue syndrome, but also other conditions characterized by in the hypothalamic-pituitary-adrenal axis mainly diminished the corticotropin realising factor activity.Descriptors: Melancholic depression; Seasonal affective disorder; Fatigue syndrome, chronic; Hypothalamus-hypophyseal system; Corticotropin releasing factor Resumo Objetivo: Foram revisados estudos que descrevem que as alterações na função do eixo hipotálamo-pituitária-adrenal e são relacionadas com o estado psicopatológico em depressão. Além da depressão melancólica, uma série de condições podem ser associadas à hiperativação prolongada do eixo hipotálamo-pituitária-adrenal. Um outro grupo de psicopatologias é caracterizado por hipoativação do mesmo eixo com redução crônica na secreção do fator de liberação de corticotrofina. Pacientes com depressão atípica, doença afetiva sazonal e síndrome da fadiga crônica estão inclusos nesta categoria. Método: Foram revisados os dados da literatura que incluem a interseção entre estes descritores, resumidos e discutidos os principais e recentes achados. Resultados: Muitos estudos têm enfatizado que estes quadros se sobrepõem biologicamente, demonstrando hipofunção no sistema relacionado ao fator de liberação de corticotrofina. Conclusões: Na prática clínica, os pacientes frequentemente se apresentam de forma intermediária entre a fadiga e a depressão atípica crônica e/ou a depressão sazonal. Isto enfatiza o potencial biológico comum que fundamenta o grupo de s...

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Gender differences in chronic major and double depression

Cited by 434 publications

References 40 publications

Gender Differences In Anxiety, Depression And Metacognition

Gender Differences In Anxiety, Depression And Metacognition

Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior

Superposição entre depressão atípica, doença afetiva sazonal e síndrome da fadiga crônica

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