Gender differences in the prediction of problem alcohol use in adulthood: exploring the influence of family factors and childhood maltreatment.

Galaif, Elisha R.; Stein, Judith A.; Newcomb, Michael D.; Bernstein, David P.

doi:10.15288/jsa.2001.62.486

Cited by 65 publications

(43 citation statements)

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“…Women exposed to CSA have an increased risk for different psychopathologies in adulthood including addictions to alcohol and other drugs; [2][3][4][5][6] antisocial personality disorder (ASPD); 4,5 major depression, 7-9 suicidal behavior; 4,8,10,11 post-traumatic stress disorder 4,12,13 and eating disorders. 6 The impact of CSA on adult mental health is only one of the complex set of intercorrelated social, economic and familial disadvantages and as such the presence of CSA is an indicator of a wider and larger dysfunction within families.…”

Section: Introductionmentioning

confidence: 99%

Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women

et al. 2007

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Women who have experienced childhood sexual abuse (CSA) have an increased risk of alcoholism and antisocial personality disorder (ASPD). Among male subjects, a functional polymorphism (MAOA-LPR, monoamine oxidase A linked polymorphic region) in the promoter region of the monoamine oxidase A gene (MAOA) appears to moderate the effect of childhood maltreatment on antisocial behavior. Our aim was to test whether MAOA-LPR influences the impact of CSA on alcoholism and ASPD in a sample of 291 women, 50% of whom have experienced CSA; we also tested whether haplotypes covering the region where both MAOA and monoamine oxidase B (MAOB) genes are located predict risk of alcoholism and ASPD better than the MAOA-LPR locus alone. Participants included 168 alcoholics (39 with ASPD (antisocial alcoholics) and 123 controls (no alcoholics, no ASPD). Antisocial behavior was also modeled as a continuous trait: ASPD symptoms count. The MAOA-LPR low activity allele was associated with alcoholism (P = 0.005), particularly antisocial alcoholism (P = 0.00009), only among sexually abused subjects. Sexually abused women who were homozygous for the low activity allele had higher rates of alcoholism and ASPD, and more ASPD symptoms, than abused women homozygous for the high activity allele. Heterozygous women displayed an intermediate risk pattern. In contrast, there was no relationship between alcoholism/antisocial behavior and MAOA-LPR genotype among non-abused women. The MAOA-LPR low activity allele was found on three different haplotypes. The most abundant MAOA haplotype containing the MAOA-LPR low activity allele was found in excess among alcoholics (P = 0.008) and antisocial alcoholics (P = 0.001). Finally, a MAOB haplotype, which we termed haplotype C, was significantly associated with alcoholism (P = 0.006), and to a lesser extent with antisocial alcoholism (P = 0.03). In conclusions, MAOA seems to moderate the impact of childhood trauma on adult psychopathology in female subjects in the same way as previously shown among male subjects. The MAOA-LPR low activity allele appears to confer increased vulnerability to the adverse psychosocial consequences of CSA. Haplotype-based analysis of the MAOA gene appeared to strengthen the association, as compared to the MAOA-LPR locus alone. A MAOB haplotype was associated with alcoholism independently from ASPD.

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Section: Introductionmentioning

confidence: 99%

Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women

et al. 2007

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“…One prospective study, for example, found a robust CPP-AUD association (Jasinski et al, 2000); two prospective studies found the association in women only (Horwitz et al, 2001;Widom et al, 2007); and one prospective study found a null association (Galaif et al, 2001). In all of these prospective studies, however, there have been substantial levels of attrition over time (40%-75%).…”

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confidence: 99%

Childhood Physical Punishment and Later Alcohol Drinking Consequences: Evidence From a Chinese Context

Cheng¹,

Huang

Anthony

2011

J. Stud. Alcohol Drugs

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“…Early initiation of alcohol consumption (Dube et al, 2006;Edgardh and Ormstad, 2000) and heavy episodic drinking (Hussey et al, 2006;Luster and Small, 1997) have been tied to CSA history in community samples. Numerous population-based studies have documented elevated rates of alcohol-related problems (Galaif et al, 2001;Kendler et al, 2000;MacMillan et al, 2001;Pedersen and Skrondal, 1996;Spak et al, 1998;Wilsnack et al, 1997), including the onset of AUDs in late adolescence and young adulthood (Fergusson et al, 1996a;Kilpatrick et al, 2000) among individuals who have experienced CSA. For example, in a longitudinal community-based study conducted by Silverman et al (1996), women with histories of CSA were signifi cantly more likely to meet AUD criteria at age 21 than were women who had not been exposed to CSA (prevalence rates of 43.5% and 7.9%, respectively).…”

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confidence: 99%

Disentangling the Complex Association Between Childhood Sexual Abuse and Alcohol-Related Problems: A Review of Methodological Issues and Approaches

Sartor

Agrawal

McCutcheon

et al. 2008

J. Stud. Alcohol Drugs

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ABSTRACT. This review describes and evaluates methodological approaches aimed at unraveling the association between childhood sexual abuse (CSA) and later misuse of alcohol, which is complicated by the signifi cant overlap between factors that elevate risk for CSA exposure and those that increase risk for problem alcohol use. We critique methods used to distinguish direct effects of CSA events on alcohol-related outcomes from the effects of risk factors frequently present in families in which CSA exposure occurs (e.g., parental alcohol-related problems). These methods include measurement and adjustment for potentially confounding factors and the use of co-twin designs. The fi ndings across methodological approaches provide support for a CSA-specifi c risk for alcohol misuse, despite the signifi cant contribution of family background factors to overall risk, but much work remains to be done before a comprehensive model for this association can be proposed. Additional directions for research, including the incorporation of measured genes and the use of longitudinal designs, are proposed to further efforts to model the pathways from CSA to alcohol-related problems. (J. Stud.

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Gender differences in the prediction of problem alcohol use in adulthood: exploring the influence of family factors and childhood maltreatment.

Cited by 65 publications

References 0 publications

Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women

Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women

Childhood Physical Punishment and Later Alcohol Drinking Consequences: Evidence From a Chinese Context

Disentangling the Complex Association Between Childhood Sexual Abuse and Alcohol-Related Problems: A Review of Methodological Issues and Approaches

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