and PerspectiveThe present studies investigated the impact of medical and psychosocial information upon observer"s estimations of pain, emotional responses and behavioral tendencies towards another person in pain. Participants were recruited from the community (study 1: N = 39; 10 men; study 2: N = 41; 12 men), and viewed videos of 4 patients expressing pain, paired with vignettes describing absence or presence of a) medical evidence for the pain and b) psychosocial influences upon the pain experience. A similar methodology was used for study 1 and 2, except for the explicit manipulation of the presence/absence of psychosocial influences in study 2. For each patient video, participant estimations of the patient"s pain, their own distress, sympathy and inclination to help (VAS) were assessed. In both studies, results indicated lower ratings on all measures when medical evidence for pain was absent.Overall, no effect of psychosocial influences was found, except in study 2 where participants indicated to feel less distress when psychosocial influences were present. The findings suggest that pain is taken less seriously when there is no medical evidence for the pain. The findings are discussed in terms of potential mechanisms underlying pain estimations as well as implications for caregiving behavior.Perspective: The present studies indicate that observers take the pain of others less seriously in the absence of clear medical evidence for the pain. These findings are important to further understand the social context in which pain for which there is no clear medical explanation is experienced.