Gender-modulated impact of apolipoprotein A5 gene (APOA5) −1131T&gt;C and c.56C&gt;G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults

Kömürcü-Bayrak, Evrim; Onat, Altan; Poda, Mehveş; Humphries, Steve E.; Palmen, Jutta; Guclu, Filiz; Can, Günay; Erginel-Unaltuna, Nihan

doi:10.1515/cclm.2008.161

Cited by 36 publications

(47 citation statements)

References 29 publications

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“…The SNP rs662799 has a much higher MAF in Chinese populations (26.7% in Han Chinese in HapMap, 28.8% in the Hong Kong subjects and 29.3% in the Guangzhou subjects) compared to Caucasians (5-8%) and Turks (12.8%). [33][34][35] Our results should prompt the search for SNPs that occur commonly in other ethnic populations and influence triglycerides to a similar extent. At the same time, we have yet to analyze SNPs that are uncommon in Chinese and Female gender, systolic blood pressure, current smoking, alcohol drinking, hypertension, diabetes, rprimary education and Ztertiary education were allowed to enter into the regression models, but were all excluded.…”

Section: Discussionmentioning

confidence: 72%

“…A previous study in Caucasians showed a stronger association of rs662799 with plasma triglycerides in men, 3 but a study in Turkey showed that the association of the APOA5 genetic variants with plasma triglycerides and the metabolic syndrome was more significant in women than in men. 35 This may be another example of a sex difference in the contribution of an SNP to a phenotype.…”

Section: Discussionmentioning

confidence: 99%

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A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

et al. 2010

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Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 (APOA5) gene have been associated with hypertriglyceridaemia. We investigated which SNPs in the APOA5 gene were associated with triglyceride levels in two independent Chinese populations. In all, 1375 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study were genotyped for five tagging SNPs chosen from HapMap. Replication was sought in 1996 subjects from the Guangzhou Biobank Cohort Study. Among the five SNPs, rs662799 (-1131T4C) was strongly related to log-transformed triglyceride levels among Hong Kong subjects (b¼0.192, P¼2.6Â10 À13 ). Plasma triglyceride level was 36.1% higher in CC compared to TT genotype. This association was confirmed in Guangzhou subjects (b¼0.159, P¼1.3Â10 À12 ), and was significantly irrespective of sex, age group, obesity, metabolic syndrome, hypertension, diabetes, smoking and alcohol drinking. The odds ratios and 95% confidence interval for plasma triglycerides Z1.7 mmol/l associated with TC and CC genotypes were, respectively, 1.81 (1.37-2.39) and 2.22 (1.44-3.43) in Hong Kong and 1.27 (1.05-1.54) and 1.97 (1.42-2.73) in Guangzhou. Haplotype analysis suggested the association was due to rs662799 only. The corroborative findings in two independent populations indicate that the APOA5-1131T4C polymorphism is an important and clinically relevant determinant of plasma triglyceride levels in the Chinese population.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

et al. 2010

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“…In a Singaporean population, both male and female carriers of the C allele of APOA5- 1131T>C had higher TG levels [40]. In another study, no such association was found in a middle-aged and elderly Turkish male population [41]. It is well established that a HC/LF diet can induce HTG [11].…”

Section: Discussionmentioning

confidence: 99%

Elevated Levels of Triglyceride and Triglyceride-Rich Lipoprotein Triglyceride Induced by a High-Carbohydrate Diet Is Associated with Polymorphisms of <i>APOA5-</i>1131T>C and <i>APOC3-</i>482C>T in Chinese Healthy Young Adults

Lin¹,

Fang²,

Du³

et al. 2011

Ann Nutr Metab

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Background/Aims: Changes in lipid profiles have been shown to be associated with diet and apolipoprotein (APO) polymorphisms. Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-carbohydrate/low-fat (HC/LF) diet intervention. Methods: After a wash-out diet for 7 days, 56 young adults (22.89 ± 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured. Results: APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender. Conclusions: Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort.

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“…Because the articles by Grallert et al (2007) and Ong et al (2011) included two separate groups, respectively, these groups were considered as two independent studies. Finally, 12 studies from 10 articles (Grallert et al, 2007;Yamada et al, 2007;Dallongeville et al, 2008;Hsu et al, 2008;Komurcu-Bayrak et al, 2008;Mattei et al, 2009;Kisfali et al, 2010;Niculescu et al, 2010;Ong et al, 2011;Vasilopoulos et al, 2011) were included in our meta-analysis. Among 10 publications, only Ong' study (Ong et al, 2011) Table 1.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…As higher triglyceride is one crucial risk factor in the development of many diseases, including MetS, the polymorphism of the ApoA5 gene may be involved in MetS. Indeed, several studies in different populations have found the association between the ApoA5 polymorphism and the risk of MetS (Grallert et al, 2007;Yamada et al, 2007;Dallongeville et al, 2008;Hsu et al, 2008;Komurcu-Bayrak et al, 2008;Mattei et al, 2009;Kisfali et al, 2010;Niculescu et al, 2010;Ong et al, 2011;Vasilopoulos et al, 2011). However, these results are not quite consistent; therefore, we conducted a meta-analysis to clarify the exact association between the ApoA5 polymorphism and the risk of MetS.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

Liu

Yang²,

Chen³

et al. 2012

Genetic Testing and Molecular Biomarkers

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Gender-modulated impact of apolipoprotein A5 gene (APOA5) −1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults

Abstract: Excess risk for low HDL-C, dyslipidemia and MS is associated with the rare alleles of the APOA5 SNPs and non-carriers of common haplotype in women.

Cited by 36 publications

References 29 publications

A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

Elevated Levels of Triglyceride and Triglyceride-Rich Lipoprotein Triglyceride Induced by a High-Carbohydrate Diet Is Associated with Polymorphisms of <i>APOA5-</i>1131T>C and <i>APOC3-</i>482C>T in Chinese Healthy Young Adults

Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

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