Gene-culture coevolution between cattle milk protein genes and human lactase genes

Beja‐Pereira, Albano; Luikart, Gordon; England, Phillip R.; Bradley, Daniel G.; Jann, O.; Bertorelle, Giorgio; Chamberlain, Andrew; Nunes, Telmo; Metodiev, S.; Ferrand, Nuno; Erhardt, G.

doi:10.1038/ng1263

Cited by 282 publications

(196 citation statements)

References 12 publications

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“…As a consequence, the frequency of lactase persistence has increased rapidly in the generations to follow. This hypothesis has been described in literature as the 'culture-historical hypothesis' 7,8 and has been supported by recent studies in the Neolithic samples from Central, Mediterranean and Northern Europe [9][10][11] and medieval samples from Central Europe. 3 Burger et al 9 reported the absence of lactase persistence in a total number of nine early Neolithic Central Europeans (7500 YBP), which argues that in this era Europeans were predominantly lactase deficient in adulthood.…”

Section: Introductionmentioning

confidence: 57%

Low prevalence of lactase persistence in Neolithic South-West Europe

et al. 2012

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The ability of humans to digest the milk component lactose after weaning requires persistent production of the lactoseconverting enzyme lactase. Genetic variation in the promoter of the lactase gene (LCT) is known to be associated with lactase production and is therefore a genetic determinant for either lactase deficiency or lactase persistence during adulthood. Large differences in this genetic trait exist between populations in Africa and the Middle-East on the one hand, and European populations on the other; this is thought to be due to evolutionary pressures exerted by consumption of dairy products in Neolithic populations in Europe. In this study, we have investigated lactase persistence of 26 out of 46 individuals from Late Neolithic through analysis of ancient South-West European DNA samples, obtained from two burials in the Basque Country originating from 5000 to 4500 YBP. This investigation revealed that these populations had an average frequency of lactase persistence of 27%, much lower than in the modern Basque population, which is compatible with the concept that Neolithic and post-Neolithic evolutionary pressures by cattle domestication and consumption of dairy products led to high lactase persistence in Southern European populations. Given the heterogeneity in the frequency of the lactase persistence allele in ancient Europe, we suggest that in Southern Europe the selective advantage of lactose assimilation in adulthood most likely took place from standing population variation, after cattle domestication, at a post-Neolithic time when fresh milk consumption was already fully adopted as a consequence of a cultural influence.

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Section: Introductionmentioning

confidence: 57%

Low prevalence of lactase persistence in Neolithic South-West Europe

et al. 2012

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“…Milk protein diversity showed Beetal as a unique breed indicating the need to conserve the germplasm as the breed is facing extinction in its home tract for several reasons. Moreover, milk protein gene diversity has been analysed in order to explain the cultural evolution of the lactase gene between humans and bovines and also for use in establishing geographical diversity and conservation decisions (Beja-Pereira et al, 2003). Indian goat breeds are showing considerable variability at the CSN1S1 gene in different geographical areas, and this needs further study to establish the relationship between the utility of goat germplasm in relation to human food, habit and migration.…”

Section: Discussionmentioning

confidence: 99%

“…However, casein variability has not been well characterised in Indian goats except for the reports of Prakash et al (2002) and Rout et al (2004a). Moreover, milk protein gene diversity in cattle showed a strong relationship with human lactase gene and has been used to analyse geographical and genetic diversity in European cattle (Beja-Pereira et al, 2003). India has a high goat population, which is distributed over all the regions of the country, and produce significant amount of goat milk.…”

Section: Introductionmentioning

confidence: 99%

Identification of the CSN1S1 allele in Indian goats by the PCR-RFLP method

Kumar

Rout

Mandal

et al. 2007

Animal

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The allelic distributions of the CSN1S1 (as 1 -casein) in the Indian goats are quite different from European goat breeds. Majority of Indian goat breeds and non-descript goats carry A, B, E and F alleles at as 1 -casein locus, as found by analysing both DNA and protein levels. However, A and B alleles, known to be associated with better casein yield, were observed in the highest proportion in all the Indian goat breeds. Gene frequency and breed heterozygosity were computed for the CSN1S1 gene. The gene frequency of allele A in Indian goats varies from 0.68 to 1.00 and allele B varies from 0.098 to 0.23. Allele F was observed in Beetal, Marwari, Chegu and non-descript goats of MP (Local MP) in less than 1% of population. The expected heterozygosity (He) varied from 0.141 to 0.506 over the population. The Beetal breed showed the highest gene diversity (0.506) followed by Jamunapari (0.395), Chegu (0.383) and Jakhrana (0.381) breeds. Therefore, the variability at CSN1S1 locus can be utilised for conservation as well as for genetic improvement of Indian goat breeds for increasing both the quality and quantity of milk production.

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“…The evolution and adaptation of pigs are subject to environmental influences, as has been observed in humans (Storz 2010), humans and cattle (Beja‐Pereira et al., 2003), fish (Nielsen et al., 2009), and other species (Manthey & Moyle, 2015). The genetic variability and population structure found were similar to other populations (Boitard et al., 2010; Burgos‐Paz et al., 2012) and other approaches (Sollero et al., 2009).…”

Section: Discussionmentioning

confidence: 99%

Landscape genomic approach to detect selection signatures in locally adapted Brazilian swine genetic groups

Cesconeto

Joost

McManus

et al. 2017

Ecology and Evolution

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Samples of 191 animals from 18 different Brazilian locally adapted swine genetic groups were genotyped using Illumina Porcine SNP60 BeadChip in order to identify selection signatures related to the monthly variation of Brazilian environmental variables. Using BayeScan software, 71 SNP markers were identified as FST outliers and 60 genotypes (58 markers) were found by Samβada software in 371 logistic models correlated with 112 environmental variables. Five markers were identified in both methods, with a Kappa value of 0.073 (95% CI: 0.011–0.134). The frequency of these markers indicated a clear north–south country division that reflects Brazilian environmental differences in temperature, solar radiation, and precipitation. Global spatial territory correlation for environmental variables corroborates this finding (average Moran's I = 0.89, range from 0.55 to 0.97). The distribution of alleles over the territory was not strongly correlated with the breed/genetic groups. These results are congruent with previous mtDNA studies and should be used to direct germplasm collection for the National gene bank.

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Gene-culture coevolution between cattle milk protein genes and human lactase genes

Cited by 282 publications

References 12 publications

Low prevalence of lactase persistence in Neolithic South-West Europe

Low prevalence of lactase persistence in Neolithic South-West Europe

Identification of the CSN1S1 allele in Indian goats by the PCR-RFLP method

Landscape genomic approach to detect selection signatures in locally adapted Brazilian swine genetic groups

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