This program of research, which was guided by Haddon's Matrix and deterrence theory conceptual frameworks, essentially had five core objectives. These objectives were examined through five independent studies. The studies were broadly interwoven to clarify understanding in three broad thematic areas relating to the impact of alcohol use on road traffic crashes in Northern Ghana: (a) general behaviour (i.e., knowledge, attitudes and practices) regarding alcohol impairment as a risk factor for ii Alcohol Use and Traffic Crash Severity in Ghana road users, (b) police reported alcohol and illicit drug use and the relative risk of road traffic crashes, and (c) the impact of alcohol use on road traffic injury severity.Study 1 (Chapter 5) primarily aimed to determine knowledge, attitudes and practices regarding alcohol drinking and driving in three cities in Ghana. The study was a survey conducted at washing bays, lorry terminals and fuel stations. Study 1 established that 24% of all motorists and 54% of motorists who were current alcohol users reported having driven within an hour after consuming alcohol. Current alcohol users typically consume four standard drinks per drinking occasion. Further, participants who were current alcohol users were significantly more likely to be arrested for traffic violations compared with non-alcohol users. It was apparent that enforcement of drink-driving law and motorists' knowledge of the BAC law were low.