General Nanomedicine Platform by Solvent-Mediated Disassembly/Reassembly of Scalable Natural Polyphenol Colloidal Spheres

Zeng, Yi; Chen, Xiangyu; Chen, Guangcan; Deng, Zhiwen; Tong, Qiulan; Sun, Zhe; Ma, Xiaomin; Su, Wen; Ma, Lei; Ran, Yaqin; Li, Xudong

doi:10.1021/acsami.0c11650

Cited by 33 publications

(28 citation statements)

References 44 publications

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“…Epigallocatechin gallate (EGCG) is the main active constituent of green tea polyphenols having a quantity of beneficial effects, including antioxidation, anticancer, and anti-inflammation, − and has been used for various biomedical purposes. − EGCG could efficiently eliminate the ROS due to the existence of the abundant hydroxyl groups and has been widely used as a preferred alternative of synthetic antioxidants . Flaxseed oil with a high content of essential fatty acids has a wide range of beneficial effects, such as nutrition balance and disease prevention during long-term consumption .…”

Section: Introductionmentioning

confidence: 99%

Green Tea Polyphenol-Stabilized Gel-Like High Internal Phase Pickering Emulsions

Tong

Zeng

Ran

et al. 2021

ACS Sustainable Chem. Eng.

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Food-grade high internal phase Pickering emulsions (HIPPEs), as a promising delivery system for functional substances used in the field of food, medicine, and cosmetics, have attracted considerable attention nowadays. However, most of these functional substances would be easily oxidized due to the sensitivity to oxygen, light, and heat. Therefore, it is crucial to find a new strategy which could efficiently improve the antioxidation of the Pickering system. Here, a novel antioxidative HIPPE stabilized by tea polyphenol nanoparticles (TPNPs) was prepared in this study. TPNPs with a high content of active epigallocatechin gallate component were used as stabilizers, and flaxseed oil was used as the oil phase in this Pickering system. The particle size, zeta potential, morphology, and wettability tests were carried out to investigate the feasibility of TPNPs as Pickering stabilizers. The results indicated that TPNPs with appropriate size (100–400 nm), spherical morphology, and medium wettability (θow ≈ 90°) could meet the demands of Pickering stabilizers. The stability experiments showed that Pickering emulsions exhibited a remarkable physical stability (the emulsification index was up to 100%). Notably, the antioxidant assays demonstrated that the formed emulsion still performed a strong antioxidative capacity after one-month storage. Besides, the gel-like HIPPEs were also successfully obtained at low particle concentrations (1–2%) with the help of polyethylene glycol or just at the high particle concentrations (3–4%) in this study. The rheological measurements exhibited the highly stability of the gel-like emulsions. We expected that this work would be beneficial to the transportation and protection of sensitive functional compounds which could be better used in food, cosmetics, and pharmaceutical systems.

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Section: Introductionmentioning

confidence: 99%

Green Tea Polyphenol-Stabilized Gel-Like High Internal Phase Pickering Emulsions

Tong

Zeng

Ran

et al. 2021

ACS Sustainable Chem. Eng.

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“…Considering the radical scavenging capacity and anticancer activity, the bowl-shaped polyphenol nanoparticles were promising in drug delivery. Besides, many research studies had proved that the tea polyphenol-based nanoparticles not only had high drug capacity for many drugs but also enhanced the anticancer effect of these drugs. − …”

Section: Resultsmentioning

confidence: 99%

“…When the pH was 7.4, the cumulative releases of DOX from Lys-10 (solid particle), Lys-10, and Lys-20 were 4.7, 3.9, and 4.4% after 48 h. When the pH decreased to 5.0, the releases of DOX dramatically increased to 24.2, 25.3, and 22.1% for Lys-10 (solid particle), Lys-10, and Lys-20, respectively. Researches had proved that multiple noncovalent interactions including hydrogen bonding, electrostatic, and π–π interactions contributed to the methylene blue adsorption and drug loading behavior of polyphenol-based nanoparticles. ,, The pH-dependent release behavior was attributed to electrostatic interaction between polyphenol nanoparticles and DOX. The polyphenol nanoparticles were all negatively charged in water (ζ = −33.5 ± 0.9 mV), and the model drugs (DOX) were cationic molecules.…”

Section: Resultsmentioning

confidence: 99%

Polymerization-Induced Self-Assembly of Tea Polyphenols into Open-Mouthed Nanoparticles for Active Delivery Systems and Stable Carbon Bowls

Chen

Zeng

Chen

et al. 2021

ACS Appl. Nano Mater.

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Polyphenol-based hollow nanoparticles have exhibited intriguing properties in drug delivery, catalysis, and energy storage, and the open-mouthed (bowl-shaped) structure is supposed to improve the performance of the nanoparticles by increasing the accessibility of the inner surface and the cavity. Up to now, cationic polymers, metal ions, and sacrificial templates are generally applied in the preparation of the polyphenol-based hollow nanoparticle, and these polyphenols are usually confined to tannin acid and lignin. Seeking for the novel assembly strategy with a wide selection of polyphenolic compounds would open a new horizon for the design, preparation, and applications of polyphenol-based functional materials. In this study, polyphenol nanoparticles with bowl-shaped structure were efficiently prepared through the polymerization-induced self-assembly of tea polyphenols in a few minutes. The formation mechanism was proposed on the basis of a series of TEM images revealing the morphology evolution process. The nanoparticles with good stability in carbonization process are candidates for bowl-shaped carbon spheres. These nanoparticles exhibit potent radical scavenging capacity, anticancer activity, high adsorption capacity of guest molecules (DOX and methylene blue), and pH-dependent release property, with promising use as active delivery systems. Moreover, the present polyphenol assembly strategy provides inspiration for fundamental studies on structure–property–function relationship of polyphenol-based materials.

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“…Although green tea polyphenol (TP) has been investigated in biomedical applications recently, − usually, green tea is still considered not suitable for recommendation to kidney stone patients. However, our previous work consolidated that green tea extracts can strongly inhibit the formation of calcium oxalate monohydrate (COM) in vitro .…”

Section: Introductionmentioning

confidence: 99%

Modulation of Rat Kidney Stone Crystallization and the Relative Oxidative Stress Pathway by Green Tea Polyphenol

Chang

Ren

et al. 2021

ACS Omega

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The role of tea polyphenol (TP) in modulating kidney stone crystallization and regulating the relative nephropathy pathway of rats was investigated. Calcium oxalate (CaOx) crystallization and oxidative stress are essential for kidney stone diseases. The kidney stone model in a rat was established by using ethylene glycol to affect the oxalic acid metabolism. The crystallization process of CaOx in the rat kidney was modulated by different TP intakes. At the same time, the effects of different types of CaOx, extracted from the rat kidney, on the proliferation and differentiation of HK-2 cells were also studied. The results showed that calcium oxalate monohydrate crystals were obtained in the blank control and the low-dose TP groups. However, CaOx crystals extracted from higher-TP-intake groups were mainly calcium oxalate dihydrate. Moreover, the size of the CaOx crystals produced in TP intake groups was much smaller than that of the blank control group. Cell experiment results show that TP can effectively reduce the damage of CaOx crystals to HK-2 cells. Further research found that TP can significantly improve oxidative stress in cases of kidney stones. TP has been proven to control CaOx crystallization in vitro, but the in vivo research results obtained through the rat stone model in this paper are novel and originally important for researching the relationship between tea drinking and preventive treatment of kidney stone diseases.

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General Nanomedicine Platform by Solvent-Mediated Disassembly/Reassembly of Scalable Natural Polyphenol Colloidal Spheres

Cited by 33 publications

References 44 publications

Green Tea Polyphenol-Stabilized Gel-Like High Internal Phase Pickering Emulsions

Green Tea Polyphenol-Stabilized Gel-Like High Internal Phase Pickering Emulsions

Polymerization-Induced Self-Assembly of Tea Polyphenols into Open-Mouthed Nanoparticles for Active Delivery Systems and Stable Carbon Bowls

Modulation of Rat Kidney Stone Crystallization and the Relative Oxidative Stress Pathway by Green Tea Polyphenol

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