In the last three decades, the RC4 has been the most cited stream cipher, due to a large amount of research carried out on its operation. In this sense, dissimilar works have been presented on its performance, security, and usability. One of the distinguishing features that stand out the most is the sheer number of RC4 variants proposed. Recently, a weakness has been reported regarding the existence of statistical dependence between the inputs and outputs of the RC4, based on the use of the strict avalanche criterion and the bit independence criterion. This work analyzes the influence of this weakness in some of its variants concerning RC4. The five best-known variants of RC4 were compared experimentally and classified into two groups according to the presence or absence of such a weakness.