2021
DOI: 10.5606/tftrd.2021.5723
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Generalized neutrophilic fixed drug eruption induced by gabapentin

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Cited by 4 publications
(7 citation statements)
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“…The presence of abundant neutrophils in FDE may lead to difficulty in differentiating these cases from neutrophilic conditions, especially Sweet syndrome (SS). Both Soares et al 10 and Acar et al 15 reported cases with prominent clinical pathological resemblance to drug-induced SS (DISS). In both cases, the presentation fulfilled diagnostic criteria for SS (fever, response to steroids, and biopsy showing a neutrophilic infiltrate without neutrophilic leukocytosis while histologically the epidermis was seemingly relatively spared) and the diagnosis of FDE was based only on the fact that lesions appeared on the same site.…”
Section: Discussionmentioning
confidence: 99%
“…The presence of abundant neutrophils in FDE may lead to difficulty in differentiating these cases from neutrophilic conditions, especially Sweet syndrome (SS). Both Soares et al 10 and Acar et al 15 reported cases with prominent clinical pathological resemblance to drug-induced SS (DISS). In both cases, the presentation fulfilled diagnostic criteria for SS (fever, response to steroids, and biopsy showing a neutrophilic infiltrate without neutrophilic leukocytosis while histologically the epidermis was seemingly relatively spared) and the diagnosis of FDE was based only on the fact that lesions appeared on the same site.…”
Section: Discussionmentioning
confidence: 99%
“…Neutrophilic FDE has previously been reported to be associated with naproxen, as was seen in Case 1 above 8,9 . Other reported causative agents include amoxicillin–clavulanic acid, sulfamethoxazole–trimethoprim, etoricoxib, and gabapentin 5,6,8,11,12 . Interestingly, the entity has also been reported in a case of seafood ingestion, aptly termed “neutrophilic fixed food eruption.” 13 …”
Section: Discussionmentioning
confidence: 89%
“…However, the term “neutrophilic fixed drug eruption” was chosen given the recurrent and fixed nature of the lesions clinically 5 . This constellation of findings has been subsequently reported in several other cases of neutrophilic FDE 6,7,9,20 . Conversely, a case showing the typical epidermal interface changes of classic FDE with an underlying inflammatory infiltrate containing neutrophils has also been reported 8 …”
Section: Discussionmentioning
confidence: 99%
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“…Histopathological differentials to be considered are Sweet's syndrome, autoinflammatory urticaria and acute generalised exanthematous pustulosis. Generalised neutrophilic fixed drug eruption has been described due to gabapentin 37 and etoricoxib. 38…”
mentioning
confidence: 99%