Generating patterned arrays of photoreceptors

Morante, Javier; Desplan, Claude; Çelik, Arzu

doi:10.1016/j.gde.2007.05.003

Cited by 46 publications

(46 citation statements)

References 47 publications

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“…Elegant work on regulation of opsin gene expression in the Drosophila eye has recently identified a number of genes that act positively or negatively in this process (Morante et al 2007). Analysis of the Rhodopsin (Rh) gene regulatory regions has revealed a proximal region that acts as a core promoter and a distal region that confers cell-type specificity (Mismer and Rubin 1987;Fortini and Rubin 1990), a pattern of organization that is consistent with our results.…”

Section: Discussionsupporting

confidence: 88%

Regulation of Odor Receptor Genes in Trichoid Sensilla of the Drosophila Antenna

Miller

Carlson

2010

Genetics

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This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the nucleotide sequences flanking a receptor gene dictate its expression in a particular neuron. Previous investigation has primarily concerned the maxillary palp, the simpler of the fly's two olfactory organs. Here we focus on genes encoding four antennal receptors that respond to fly odors in an in vivo expression system. To investigate the logic of odor receptor expression, we carry out a genetic analysis of their upstream regulatory sequences. Deletion analysis reveals that relatively short regulatory regions are sufficient to confer expression in the appropriate neurons, with limited if any misexpression. We find evidence for both positive and negative regulation. Multiple repressive functions restrict expression to the antenna, to a region of the antenna, and to neurons. Through deletion and base substitution mutagenesis we identify GCAATTA elements and find evidence that they act in both positive and negative regulation.

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Section: Discussionsupporting

confidence: 88%

Regulation of Odor Receptor Genes in Trichoid Sensilla of the Drosophila Antenna

Miller

Carlson

2010

Genetics

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“…Sequential differentiation of the other seven photoreceptor types (R1-R7) occurs in four steps that are timed approximately four hours apart [4]. Each R8 neuron recruits one cell of each type, such that seven photoreceptors cluster around each R8 neuron [5]. Subsequently, four non-neuronal cells per ommatidium are recruited to differentiate-these are called cone cells.…”

Section: Introductionmentioning

confidence: 99%

Pattern formation in the Drosophila eye

Carthew

2007

Current Opinion in Genetics & Development

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The insect compound eye is one of the most precise and highly ordered patterns in the living world. It develops from an unpatterned simple epithelium by a series of cell fate decisions and complex morphogenetic movements. In the first days of metamorphosis, this interplay is particularly noticeable. Recent insights have revealed how interactions between neighboring cells drive the process. Interaction between Delta on cone cells and Notch proteins on the surface of neighbors induces the first pigment cells to differentiate. The primary pigment cells then express a Nephrin protein, Hibris, that interacts with a different Nephrin, Roughest, on their neighbors. Heterophilic adhesion between Hibris and Roughest result in remodeling contacts between cells to favour their contact with the pigment cells. In conjunction, the primary pigment cells signal to neighbors through the EGF Receptor to survive rather than undergo apoptosis. This sorting and culling process results in a sculpted pattern with a precise number and position of cells that is repeated hundreds of times in each compound eye.

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“…The Drosophila eye is composed of a pattern of eight photoreceptors (R1-R8) called ommatidia and has been used for detailed analysis of spatial aspects of differentiation (Carthew, 2007;Morante et al, 2007). Upon loss of TSC1, the photoreceptors 1, 6, and 7 and non-neuronal cone cells differentiate prematurely.…”

Section: Pro-growth Role Of Rhebmentioning

confidence: 99%

Rheb in neuronal degeneration, regeneration, and connectivity

Potheraveedu

Schöpel

Stoll

et al. 2017

Biological Chemistry

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Abstract:The small GTPase Rheb was originally detected as an immediate early response protein whose expression was induced by NMDA-dependent synaptic activity in the brain. Rheb's activity is highly regulated by its GTPase activating protein (GAP), the tuberous sclerosis complex protein, which stimulates the conversion from the active, GTP-loaded into the inactive, GDP-loaded conformation. Rheb has been established as an evolutionarily conserved molecular switch protein regulating cellular growth, cell volume, cell cycle, autophagy, and amino acid uptake. The subcellular localization of Rheb and its interacting proteins critically regulate its activity and function. In stem cells, constitutive activation of Rheb enhances differentiation at the expense of self-renewal partially explaining the adverse effects of deregulated Rheb in the mammalian brain. In the context of various cellular stress conditions such as oxidative stress, ER-stress, death factor signaling, and cellular aging, Rheb activation surprisingly enhances rather than prevents cellular degeneration. This review addresses cell type-and cell state-specific function(s) of Rheb and mainly focuses on neurons and their surrounding glial cells. Mechanisms will be discussed in the context of therapy that interferes with Rheb's activity using the antibiotic rapamycin or low molecular weight compounds.

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Generating patterned arrays of photoreceptors

Cited by 46 publications

References 47 publications

Regulation of Odor Receptor Genes in Trichoid Sensilla of the Drosophila Antenna

Regulation of Odor Receptor Genes in Trichoid Sensilla of the Drosophila Antenna

Pattern formation in the Drosophila eye

Rheb in neuronal degeneration, regeneration, and connectivity

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