Generation of Cytotoxic Singlet Oxygen via Phthalocyanine-Stabilized Gold Nanoparticles:  A Potential Delivery Vehicle for Photodynamic Therapy

Hone, Duncan C.; Walker, Peter I.; Evans-Gowing, Richard; FitzGerald, Simon; Beeby, Andrew; Chambrier, Isabelle; Cook, Michael J.; Russell, David A.

doi:10.1021/la0256230

Cited by 296 publications

(206 citation statements)

References 26 publications

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“…PS can be modified by encapsulated them in delivery agents such as liposomes [54], micelles [55,56,57,58], ceramic based nanoparticles [59], gold nanoparticles [60,61], and polymer nanoparticles [62]. Liposomes, for example, are able to encapsulate hydrophobic as well as hydrophilic drugs.…”

Section: 'Nano' Strategies For Photosensitizermentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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Section: 'Nano' Strategies For Photosensitizermentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

View full text Add to dashboard Cite

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“…The nontoxicity, biocompatibility, and inert nature of gold nanoparticles make them ideal as drug carriers. These nanoparticles can be conjugated to phthalocyanine photosensitizers as drug carriers [11].…”

mentioning

confidence: 99%

The use of phthalocyanines in cancer therapy

Nyokong¹,

Gledhill²

2013

AIP Conference Proceedings

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Abstract. Phthalocyanines are synthetic analogues of porphyrins employed as photosensitizers in cancer therapy. We present the history of photodynamic therapy and developments in the use of phthalocyanines as photosensitizers. New efforts in the development of more cancer-specific phthalocyanines are presented. The combination of phthalocyanines with nanoparticles for "combination therapy" of cancer is also discussed. The nanoparticles employed are quantum dots, gold, and magnetic nanoparticles.

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“…There have been several reports of nanoparticles as carriers for singlet oxygen photosensitizers. [5][6][7] Nanoparticles can be ideal carriers of photosensitizer molecules for PDT. Moreover, some nanomaterials can generate singlet oxygen.…”

mentioning

confidence: 99%

Singlet Oxygen Generation from Water-Soluble Quantum Dot−Organic Dye Nanocomposites

2006

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Water-soluble quantum dot -organic dye nanocomposites have been prepared via electrostatic interaction. We used CdTe quantum dots with diameters up to 3.4 nm, 2-aminoethanthiol as a stabilizer, and meso-tetra (4-sulfonatophenyl) porphine dihydrochloride (TSPP) as an organic dye. The photophysical properties of the nanocomposite have been investigated. The fluorescence of the parent CdTe quantum dot is largely suppressed. Instead, indirect excitation of the TSPP moiety leads to production of singlet oxygen with a quantum yield of 0.43. The nanocomposite is sufficiently photostable for biological applications.Colloidal semiconductor nanocrystals (Quantum Dots, QDs) can provide three-dimensional (3D) architectures and have attracted widespread interest, since their nano-size physical properties are quite different from those of bulk materials. 1 QDs photoluminescence can be size-tuned to improve spectral overlap with a particular acceptor, and having several acceptors interact with a single QDs donor substantially improves fluorescence resonance energy transfer (FRET) efficiency. Retaining the small probe size is critical for successful in vivo applications since large-sized probes significantly reduce biostability, diffusion, and circulation processes, and increase undesired nonspecific binding. 2 The small size of QDs is valuable for enhancing biological targeting efficiency and specificity. 3 Photodynamic therapy (PDT) is an emerging modality for the treatment of a variety of oncological, dermatological, and other types of cancer. 4 Singlet oxygen ( 1 O 2 ) is believed to be a major cyctotoxic species in this process. There have been several reports of nanoparticles as carriers for singlet oxygen photosensitizers. 5-7 Nanoparticles can be ideal carriers of photosensitizer molecules for PDT. Moreover, some nanomaterials can generate singlet oxygen. 8,9 Although this area has not received as much attention as the application of nanomaterials to electronics or catalysis, it represents a promising route to overcoming many We report herein the preparation of water-soluble QDs, using Meso-Tetra (4-sulfonatophenyl) Porphine Dihydrochloride (TSPP) as a photosensitizer, bound to CdTe nanocrystals via electrostatic interactions. The advantage of the electrostatic approach used in our work is that it allows control over the assembly behavior in solution. 14 The CdTe QDs were synthesized with 2-aminoethanethiol as surface stabilizer. Synthesis of yellow photofluorescence CdTe nanocrystal was performed via a modified protocol adopted from the literature. 15 The CdTe QDs revealed size-dependent luminescence with maxima at 560 nm. In a typical assay, the UV-vis spectra of QD-TSPP nanocomposites shifted slightly to the blue region,compared with free TSPP (Figure 1a). This could be surface caused by surface plasma changes as TSPP deposited on the of the QDs aggregates. 16 The UV-vis peak of CdTe-TSPP nanocomposites increased with the concentration of added TSPP.Immediate aggregation was observed when the concentration of...

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Generation of Cytotoxic Singlet Oxygen via Phthalocyanine-Stabilized Gold Nanoparticles: A Potential Delivery Vehicle for Photodynamic Therapy

Cited by 296 publications

References 26 publications

Nanodrug applications in photodynamic therapy

Nanodrug applications in photodynamic therapy

The use of phthalocyanines in cancer therapy

Singlet Oxygen Generation from Water-Soluble Quantum Dot−Organic Dye Nanocomposites

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