Genetic association of the transcription of neuroplasticity‐related genes and variation in stress‐coping style

Aizawa, Saeko; Ishitobi, Yoshinobu; Masuda, Koji; Inoue, Ayako; Oshita, Harumi; Hirakawa, Hirofumi; Ninomiya, Taiga; Maruyama, Yoshihiro; Tanaka, Yoshihiro; Okamoto, Keitaro; Kawashima, Chiwa; Nakanishi, Mari; Higuma, Haruka; Kanehisa, Masayuki; Akiyoshi, Jotaro

doi:10.1002/brb3.360

Cited by 19 publications

(18 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another possible explanation may be differences in methods used to measure coping behaviors and the characteristics of the participants among studies (eg, age). For example, participants in this study were much older than those in a previous study showing a significant association between BDNF and emotion‐focused coping (average age: 55.0 vs 24.5 years, respectively) . Older participants exhibit reduced heritability of emotional regulation, possibly due to better skills for emotional regulation and advantageous characteristics (eg, more experience in coping with stress and higher social position).…”

Section: Discussionmentioning

confidence: 55%

“…While candidate gene studies have examined genetic associations with coping behaviors, no such genome‐wide association study (GWAS) has been performed. Candidate gene studies have shown that polymorphisms in BDNF , NTRK2 , SLC64A and ADRB2 , which contribute to adaptation for psychosocial stress, are associated with some coping behaviors . As these candidate gene studies have only showed limited associations between coping behaviors and specific single nucleotide polymorphisms (SNPs), GWASs are needed to discover associations between unknown genes and coping behaviors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A genome‐wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

Shimanoe

Hachiya

Hara

et al. 2018

Genes Brain and Behavior

View full text Add to dashboard Cite

Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

A genome‐wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

Shimanoe

Hachiya

Hara

et al. 2018

Genes Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…Data revealed that the SNPs of the TrkB gene affected the mechanisms that are used to cope with stress in young Japanese people. It is worth stressing that individuals with the T/T genotype (polymorphic) of rs10868235 had lower scores for the cognitive strategies for relieving stress [19]. Cognitive impairment is common in schizophrenia patients, and stress is an important factor that modulates both the occurrence of and the course of schizophrenia [20,21].…”

Section: Discussionmentioning

confidence: 99%

An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism

et al. 2020

View full text Add to dashboard Cite

Aim. The BDNF dysfunction in the schizophrenia has been soundly documented. The TrkB gene is a high-affinity receptor of the BDNF that is changed in schizophrenia and mood disorders. The study had two aims: first, to identify whether the five nucleotide polymorphisms (SNPs) in TrkB gene are associated with a diagnosis of schizophrenia; and the latter, if any association exists between the TrkB SNPs and psychopathology, suicide attempts, and family history of schizophrenia in a Caucasian population. Methods. Case-control study (401 patients and 657 healthy controls) was used to examine a predisposition for schizophrenia. The tests for psychopathology, suicide attempts, and family history of schizophrenia were conducted only in patient group. The severity of the schizophrenia was measured using the five-factor model of the PANSS. In addition, the haplotype analysis for both the separate for SNPs of TrkB gene and in combination with the rs6265 SNP BDNF gene was conducted. Results. Our case-control study revealed that the genetic variants of rs10868235 (T/T polymorphic genotype) and rs1387923 (G/G polymorphic genotype) of the TrkB gene were associated with a higher risk of developing schizophrenia in men. However, the A/A wild genotype of rs1387923 was connected with a lower risk for both the development of and the family manifestation of schizophrenia in men. The G polymorphic allele of rs1565445 was associated with an increased risk of suicide in schizophrenia. The tested SNPs of the TrkB gene did not modulate the psychopathology of schizophrenia. The haplotype that was built with five SNPs in the TrkB gene was protective for men, but after joining the rs6265 SNP of the BDNF gene, a haplotype that was protective for women was created.

show abstract

“…Another candidate gene we examined in mice is SPRY2 , which encodes a protein that suppresses the actions of several neurotrophic factors (Kramer et al, 1999; Cabrita and Christofori, 2003; Rubin et al, 2003; Zhang et al, 2005; Gross et al, 2007) that may play role in coping with stress (Aizawa et al, 2015). Stress coping induced downregulation of SPRY2 observed in monkeys could therefore enhance neurotrophic actions and promote neural adaptations like those observed with decreased SPRY2 expression in rat models of electroconvulsive therapies for major depression (Ongur et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Learning to cope with stress modulates anterior cingulate cortex stargazin expression in monkeys and mice

Lee

Capanzana

Brockhurst

et al. 2016

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

Intermittent mildly stressful situations provide opportunities to learn, practice, and improve coping with gains in subsequent emotion regulation. Here we investigate the effects of learning to cope with stress on anterior cingulate cortex gene expression in monkeys and mice. Anterior cingulate cortex is involved in learning, memory, cognitive control, and emotion regulation. Monkeys and mice were randomized to either stress coping or no-stress treatment conditions. Profiles of gene expression were acquired with HumanHT-12v4.0 Expression BeadChip arrays adapted for monkeys. Three genes identified in monkeys by arrays were then assessed in mice by quantitative real-time polymerase chain reaction. Expression of a key gene (PEMT) involved in acetylcholine biosynthesis was increased in monkeys by coping but this result was not verified in mice. Another gene (SPRY2) that encodes a negative regulator of neurotrophic factor signaling was decreased in monkeys by coping but this result was only partly verified in mice. The CACNG2 gene that encodes stargazin (also called TARP gamma-2) was increased by coping in monkeys as well as mice randomized to coping with or without subsequent behavioral tests of emotionality. As evidence of coping effects distinct from repeated stress exposures per se, increased stargazin expression induced by coping correlated with diminished emotionality in mice. Stargazin modulates glutamate receptor signaling and plays a role in synaptic plasticity. Molecular mechanisms of synaptic plasticity that mediate learning and memory in the context of coping with stress may provide novel targets for new treatments of disorders in human mental health.

show abstract

Genetic association of the transcription of neuroplasticity‐related genes and variation in stress‐coping style

Cited by 19 publications

References 61 publications

A genome‐wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

A genome‐wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism

Learning to cope with stress modulates anterior cingulate cortex stargazin expression in monkeys and mice

Contact Info

Product

Resources

About