Genetic determination of tuberculin hypersensitivity in chicken inbred lines

Karakoz, I; Krejcí, J; Hála, K; B, Błaszczyk; Hrabă, T; Pekárek, J

doi:10.1002/eji.1830040805

Cited by 48 publications

(20 citation statements)

References 9 publications

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“…Similar associations between the B complex and immune response have been reported for the dinitrophenyl group conjugated to chicken IgG (Balcarov/t et al 1974), for the synthetic polypeptides (T,G)-A--L (Giinther et al 1974;Balcarov/t et al 1975) and GAT 1~ (Benedict et al 1975), and for tuberculin (Karakoz et al 1974). But, so far, specific Ir genes have not been demonstrated in chickens.…”

Section: Introductionmentioning

confidence: 50%

Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system

1978

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Evidence is presented for a crossover between the genes coding for the serologically determined (SD) antigens on erythrocytes and an immune response gene (Ir-GAT) controlling immune response to the synthetic polypeptide GAT within theB complex, the MHC of chickens. TheIr-GAT (1) andIr-GAT (19) alleles control low and high immune response to GAT, respectively. Both low and high responders were recovered as recombinants fromB (1) B (1) andB (19) B (19) birds. The low-responder haplotypes are homozygous for theIr-GAT (1) allele and the high-responder haplotypes carry theIr-GAT (19) allele. Mortality forB (1) B (1) nonresponder birds was 39%, compared with 19% for theB (1) B (1) high responders; this suggests the possibility that genes located within the immune response region of theB complex exert some genetic control over viability and survival.

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Section: Introductionmentioning

confidence: 50%

Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system

1978

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“…Also, B 21 has been associated with increased antibody production to SRBC (Martin et al, 1990). Chickens with the B 13 haplotype were shown to have greater hypersensitivity to purified protein derivative of tuberculin than those with Bi (Karakoz et al, 1974). No other haplotypes were compared in the tuberculin study, however, so the relative merit of other haplotypes is not known.…”

Section: Discussionmentioning

confidence: 92%

Differences in Major Histocompatibility Complex Frequencies after Multitrait, Divergent Selection for Immunocompetence

et al. 1994

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White Leghorn chickens from lines selected for four immune-response traits (IR lines) were serotyped for B system alloantigens characterizing the haplotypes and genotypes to examine the effect of divergent selection for multitrait immunocompetence on MHC haplotype and genotype frequencies. The selected lines were derived from the Ottawa Strain 7. The selection index included four immunocompetence traits: antibody production against Mycoplasma gallisepticum (MG) and Pasteurella multocida, inflammatory response to phytohemagglutinin, and reticuloendothelial carbon clearance. The four lines include two replicates of high and low multitrait-immunocompetence lines. After four cycles of selection, significant differences (P < .05) in several B system haplotype frequencies were observed, both among IR lines and between the IR lines and the Ottawa Strain 7. The B2 haplotype frequency was greater in all IR lines than in the Ottawa Strain 7. The B21 frequency was less in both high lines than in the Ottawa Strain 7. In comparisons among lines, frequencies of B21 were greater in both replicates of the low lines and the B12 and B19 frequencies were significantly greater (P < .05) in the high lines. A gene substitution model showed effects (P < .10) of specific haplotypes on MG and on the index. The B2 haplotype had a positive effect associated with MG. Haplotype B21 was positively associated with the multitrait index. Haplotype B13 had a negative effect on both MG and the index. Significant differences (P < .01) in genotype frequencies were also noted among the IR lines. Associations between specific MHC haplotypes or genotypes and immune-response traits may offer insight into MHC-mediated mechanisms of disease resistance.

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“…It has been suggested that Ir-Uke genes analogous to those which have been studied so extensively in the mouse, also exist in the chicken. An association between the MHC and the antibody response to the following synthetic polypeptides has Guenther et al, 1974), GAT and G-A (Pevzner et al, 1978), bovine serum albumin (BSA) coupled with aggregated GAT (Benedict et al, 1977), and GT (Koch and Simonsen, 1977); Salmonella pullorum bacterium (Pevzner et cd., 1975) and the development of tuberculin hypersensitivity (Karakoz et al, 1974). …”

Section: Chicken Mhc and Immune Responsesmentioning

confidence: 99%

Isolation and characterization of cDNA clones for chicken major histocompatibility complex class II molecules

et al. 1993

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Sung, Aree Moon, "Isolation and characterization of cDNA clones for chicken major histocompatibility complex class II molecules " (1989). Retrospective Theses and Dissertations. 9089. http://lib.dr.iastate.edu/rtd/9089 INFORMATION TO USERSThe most advanced technology has been used to photo graph and reproduce this manuscript from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are re produced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book. These are also available as one exposure on a standard 35mm slide or as a 17" x 23" black and white photographic print for an additional charge.

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Genetic determination of tuberculin hypersensitivity in chicken inbred lines

Cited by 48 publications

References 9 publications

Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system

Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system

Differences in Major Histocompatibility Complex Frequencies after Multitrait, Divergent Selection for Immunocompetence

Isolation and characterization of cDNA clones for chicken major histocompatibility complex class II molecules

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