Genetic differences for fatty acids and other body components in mice

Boylan, W. J.; Roberts, Wayne

doi:10.1017/s0021859600017214

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…CaTBL/Fn were intermediate in their ability to adjust caloric intake to caloric need. ]~OYLaN and ROBEI~:rS [4] noted significant differences in four out of seven fatty acids studied, with regard to the amount deposited in the tissues of two inbred lines fed the same diet. The percent carcass protein did not differ between lines.…”

Section: Resultsmentioning

confidence: 89%

Dissociation of hyperglycaemia and obesity in mice fed high fat diets

et al. 1969

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Three groups of weanling male Swiss-/:Iauschka mice were maintained, respectively, on diets containing 4.5 (Diet I), 11.0 (Diet II), and 12.0 (Diet III) percent fat for seven months. The fat source for Diet I was mixed; for Diet II, corn oil; and for Diet III, hydrogenated vegetable oil (Crisco). The animals on Diet II showed significantIy higher total and percent extractable lipid per mouse than those fed Diet I or III. However, the animals on Diet II and III had significantly higher blood glucose levels than those on Diet I. These results suggest that certain types of high fat and/or high caloric diets may induce hyperglycaemia in mice without production of obesity. Dissociation de l'hyperglycdmie et de l'obdsitd chez des souris soumgses dun rggime fiche en mati~res grassesRgsumd. Trois groupes de jeunes souris ingles Swiss-Hausehka out 4t4 maintenues respectivement ~ des r4girues contenant 4.5 pour cent de mati@res grasses (R4gime I), 11.0% (Rdgime II) et 12.0% (Rdgime III) pendant 7 mois. Pour le rdgime I les mati@res grasses 4taient eon-stitu4es par un m41ange; pour le rdgime II, elles 4taient eonstitudes par de l'huile de c4rdales; et pour le r4gime III elles 4talent eonstitu4es par de I'huile vgggtale hydrogdnde (Criseo). Les animaux du r4gime II out montrd, par souris, un totM et un pourcentage de lipides extraetibles significativement plus 41ev4s que eeux nourris suivant le r6gime Iet III. Cependant les animaux du r6gime II et III avaient des taux de glyedmie significativement plus dlevds que eeux du r6gime I. Ces rdsultats sugg6rent que eertains types de rdgimes riches en mati6res grasses et/ou hautemerit caloriqaes peuvent produire l'hyperglye6mie chez les souris sans provoquer l'ob6sitd. Dissoziation yon BlutzuckererhShu~w und Fettsucht bei fettreich erni~hrten 2Pl4usen Zusammenfass~tng. Drei Gruppen yon 3 Wochen alten ,,Swiss-Hausehka"-Ms ms Geschlechts wurden 7 Monate lang mit verschiedenen Di/iten ern/ihrt, deren Fettgehalt 4.5 (Di/it I), 11.0 (Di/it II), und 12.0 (Di/it III) Prozent betrug. Diat I enthielt gemischtes Fett ; Di/it II Mais-Ot und Diiit III hydrogenisiertes PttanzenS1 (Crisco). Die mit Di/it II gefiitterten Tiere zeigten eine signifikante Vermehrung sowohl der gesamten, als aueh der in Prozenten ausge&'iickten Menge der extrahierbaren Lipide pro Maus, verglichen mit den mit Dis Iund III erns Tiere der Di/~t-Gruppe II und III wiederum batten signifikant h6here Blutglucosekonzentrationen als die der Di~t-Gruppe I. Es wird vermutet, dal3 verschiedene Arten yon fett-und/oder kalorienreicher Nahrung bei M/iusen Hyperglyk~mie verursachen, ohne jedoch zur Fettsueht zu fiihren.

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Section: Resultsmentioning

confidence: 89%

Dissociation of hyperglycaemia and obesity in mice fed high fat diets

et al. 1969

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Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity

Eisen

Cartwright

Weller

et al. 1982

Lipids

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Rates of depletion and half‐lives of linoleic acid from epididymal, subcutaneous and retroperitoneal fat pads and the residual body were compared among 5 genetically diverse strains of mice: M16, a polygenic obese line developed by selection for high postweaning gain; ICR, a control line from which M16 was derived; H6, a nonobese strain selected for large 6‐week body weight; L6, selected for small 6‐week body weight; and C2 a control line from which H6 and L6 were initiated. Rates of depletion and half‐lives of linoleic acid were obtained on a fat‐free diet following an enrichment period of feeding a diet high in linoleic acid. The M16 mice have an increased capability of synthesizing fat from carbohydrates as shown by a continued increase in fat depot weights when fed the fat‐free diet. The 4 other lines showed no subsequent increase in fat depot weights on the fat‐free diet. Rates of depletion of linoleic acid were significantly different among lines in each of the 4 depots. Ranking of lines for depletion rates was similar among the 3 discrete depots, but a more rapid rate of depletion was observed in subcutaneous and retroperitoneal fat depots than in the epididymal fat depot. Rates of depletion in line M16 were slower than in the ICR control line. Line H6 had a slower rate of depletion than line L6. Line L6 deviated more from the C2 control than did line H6, indicating an asymmetric correlated selection response. The decreased depletion rate of linoleic acid in fat tissue of M16 and H6 mice suggests the possibility that the turnover rates of fatty acids have been reduced in these lines as a result of a reduction in lipolytic activity. The increased depletion rate of linoleic acid in L6 mice suggests that selection for small body size has substantially increased the rate of fat turnover. The experiment demonstrates that genetic differences among lines in fat turnover have accurued as corelated responses to selection for growth rate.

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Genetic differences for fatty acids and other body components in mice

Cited by 2 publications

References 6 publications

Dissociation of hyperglycaemia and obesity in mice fed high fat diets

Dissociation of hyperglycaemia and obesity in mice fed high fat diets

Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity

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