Genetic disposition to primary hyperhidrosis: a review of literature

Henning, Mattias A S; Pedersen, Ole Birger; Jemec, Gregor B. E.

doi:10.1007/s00403-019-01966-1

Cited by 16 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some factors like certain foods and drugs, nicotine, caffeine and smell can also be aggravating factors [10] . Few cases of primary hyperhidrosis are genetically predisposed and might be either autosomal dominant or recessive pattern [5] . Secondary hyperhidrosis is mainly due to the diseases affecting peripheral nerves like diabetic neuropathy, also spinal cord diseases [11] .…”

Section: Pathophysiologymentioning

confidence: 99%

See 1 more Smart Citation

Homoeopathic management for hyperhidrosis

Kumar¹,

Shuruthi²

2022

Int. J. Homoeopathic Sci.

View full text Add to dashboard Cite

Excessive sweating is a socially embarrassing disorder, and its treatment options are receiving widespread attention. In order of frequency, palm-sole, palm-axilla, isolated axilla, and craniofacial hyperhidrosis are different disorders of sweat regulation. A common association between these disorders is an excessive non-thermoregulatory sweating response to emotional stimuli in areas of the body affected by the anterior cingulate cortex, thermoregulatory regulated by the anterior hypothalamus. This is in contrast to the sweating reaction of. Diagnosis of these mechanically ambiguous disorders is based primarily on medical history and physical examination, but the results of laboratory tests using indicator powder reveal the distribution and severity of resting hyperhidrosis.

show abstract

Section: Pathophysiologymentioning

confidence: 99%

“…Patients with hyperhidrosis frequently mention their family history [4] . The pathophysiology of localized hyperhidrosis was initially linked to gene alterations in 2006 [5] . Grimson, et al created a medicinal therapy in 1950 to treat hyperhidrosis using ant muscarinic drugs [6] .…”

Section: Introductionmentioning

confidence: 99%

Homoeopathic management for hyperhidrosis

Kumar¹,

Shuruthi²

2022

Int. J. Homoeopathic Sci.

View full text Add to dashboard Cite

show abstract

“…Los individuos con fenotipos palmoplantares y antecedentes familiares positivos suelen tener una edad de inicio más temprana. Se han encontrado dos locus para hiperhidrosis en los cromosomas 2q31.1 y 14q11.2-q13, sin embargo, la evidencia es heterogénea y limitada y parece ser que la hiperhidrosis se hereda poligenéticamente (5).…”

Section: Epidemiologíaunclassified

Actualización en diagnóstico y tratamiento de hiperhidrosis localizada primaria

Mayorga

Ureña

Pacheco

2021

View full text Add to dashboard Cite

La hiperhidrosis localizada primaria es una condición dermatológica caracterizada por una producción excesiva de sudor que supera las necesidades termoreguladoras, afectado zonas localizadas como palmas, plantas, axilas o región craneofacial. Su etiología sigue siendo incierta, aunque la evidencia sugiere un componente genético importante. El diagnóstico requiere de una historia clínica exahustiva que permita descartar causas secundarias y farmacológicas. Algunas pruebas cualitativativas y cuantitativas pueden ser de utilidad en el diagnóstico. Dada la importante afectación en la calidad de vida de los pacientes, existen diferentes opciones terapéuticas disponibles desde agentes tópicos y dispositivos médicos, hasta terapias sistémicas e intervenciones quirúrgicas. Estos varían mucho en cuanto a efectividad, seguridad, tolerabilidad y costo, por lo que se debe individualizar la terapia, tomando en consideración la afectación en la calidad de vida, la localización de la enfermedad, las contraindicaciones y las posibles complicaciones.

show abstract

“…Aetiological classifications divide HH into a primary and a secondary form 3 . Although the exact cause of primary HH is not completely understood, research has indicated a genetic predisposition of the disease 10 . A genetic linkage analyses have identified potential loci on chromosomes 1q41‐1q42.3, 2p14‐2p13.3, 2q21.2‐2q23.3, 2q31.1, 14q11.2‐q13 and 15q26.3 11‐13 .…”

Section: Introductionmentioning

confidence: 99%

“…3 Although the exact cause of primary HH is not completely understood, research has indicated a genetic predisposition of the disease. 10 A genetic linkage analyses have identified potential loci on chromosomes 1q41-1q42.3, 2p14-2p13.3, 2q21.2-2q23.3, 2q31.1, 14q11.2-q13 and 15q26.3. [11][12][13] A genome-wide association study (GWAS) on 3,293 Japanese women with the phenotype self-evaluated increased sweating, which not was validated to diagnose HH, and 1245 control individuals identified associations with single nucleotide polymorphisms (SNPs) on chromosomes 2 and 16.…”

Section: Introductionmentioning

confidence: 99%

Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

Familial clustering of the skin disease primary hyperhidrosis suggests a genetic component to the disease. The human leucocyte antigen (HLA) is implicated in a range of diseases, including many comorbidities to hyperhidrosis. No study has investigated whether the HLA genes are involved in the pathogenesis of hyperhidrosis. We, therefore, compared HLA alleles in individuals with and without hyperhidrosis in this study of 65 000 blood donors. In this retrospective cohort study, we retrieved information on individuals with and without hyperhidrosis using self‐reported questionnaires, the Danish National Patient Registry and the Danish National Prescription Registry on participants recruited to the Danish Blood Donor Study between 2010 and 2019. Association tests using logistic regression were conducted for each HLA allele corrected for sex, age, body mass index, smoking and principal components. Overall, 145 of 65 795 (0.2%) participants had hospital diagnosed hyperhidrosis. Similarly, 1379 of 15 530 (8.9%) participants had moderate‐severe self‐reported hyperhidrosis, of whom 447 (2.9%) had severe self‐reported hyperhidrosis. Altogether, 28 participants had both hospital diagnosed and moderate‐severe self‐reported hyperhidrosis. Severe self‐reported hyperhidrosis was associated with HLA‐A*80:01 (adjusted odds ratio 26.97; 95% confidence interval 5.32‐136.70; n = 7; P < .001). Moderate‐severe self‐reported hyperhidrosis and hospital diagnosed hyperhidrosis were not associated with any HLA. The association between hyperhidrosis and HLA‐A*80:01 was based on a very small number of cases and not replicated in other patient subsets, and therefore likely a chance finding. Thus, this study suggests that genes other than the HLA are involved in the pathogenesis of hyperhidrosis.

show abstract

Genetic disposition to primary hyperhidrosis: a review of literature

Cited by 16 publications

References 37 publications

Homoeopathic management for hyperhidrosis

Homoeopathic management for hyperhidrosis

Actualización en diagnóstico y tratamiento de hiperhidrosis localizada primaria

Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study

Contact Info

Product

Resources

About