Genetic features of oligodendrogliomas and presence of seizures. The relationship of seizures and genetics in LGOs

Mulligan, Linda; Ryan, Elizabeth; O’Brien, Margaret; Looby, Seamus; Heffernan, Josephine; O'Sullivan, Joanne; Clarke, Mary; Buckley, Patrick G.; O’Brien, David G.; Farrell, Michael; Brett, Francesca

doi:10.5414/np300727

Cited by 18 publications

(13 citation statements)

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“…Several previous researches have explored the association between IDH1 mutation and preoperative seizure in LGG, however, most of those studies are limited by small sample size and the results are inconsistent. For instance, Stockhammer et al and Liang et al revealed a significant correlation between IDH1 mutation and preoperative seizure in LGG [12,13], while Mulligan et al failed to find such association [14]. In the current study, we performed a comprehensive metaanalysis to investigate the relationship between IDH1 mutation and preoperative seizure incidence in LGG, and finally drew a definite conclusion on this issue.…”

Section: Introductionmentioning

confidence: 66%

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IDH1 mutation is associated with a higher preoperative seizure incidence in low-grade glioma: A systematic review and meta-analysis

Shan

et al. 2018

Seizure

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Section: Introductionmentioning

confidence: 66%

“…After the removal of duplicates, 158 abstracts were reviewed and screened. 14 studies were selected for full-text assessment, and 6 studies met the inclusion criteria [12][13][14][18][19][20]. Among the 8 excluded full-text articles, 4 of them didn't have sufficient data for analysis.…”

Section: Studiesmentioning

confidence: 99%

IDH1 mutation is associated with a higher preoperative seizure incidence in low-grade glioma: A systematic review and meta-analysis

Shan

et al. 2018

Seizure

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“…The role of EOR as the strongest predictors of postoperative seizure long-term outcome ( Table 4) has recently been demonstrated in a limited number of retrospective studies [8,[15][16][17][19][20][21][22][23]. Only two investigations examined which value of EOR corresponded to the threshold above which seizure control, defined as Engel Class level, was optimal [16,17].…”

Section: The Role Of Eormentioning

confidence: 99%

“…It is likely that LGGs, which show less infiltrative growth, as oligodendrogliomas, are less prone to modify the tumor microenvironment, comparing to infiltrative lesions. Thus, electrical signaling of peritumoral tissues may be less impaired in oligodendrogliomas [20].…”

Section: It Is a Matter Of Interaction Between Eor And Tumor Growth Pmentioning

confidence: 99%

Predictors of Postoperative Seizure Outcome in Low Grade Glioma: From Volumetric Analysis to Molecular Stratification

Ius

Pauletto

Tomasino

et al. 2020

Cancers

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The importance of the extent of resection (EOR) has been widely demonstrated as the main predictor for survival, nevertheless its effect on tumor related epilepsy is less investigated. A total of 155 patients were enrolled after a first-line surgery for supratentorial Diffuse Low Grade Gliomas (DLGGs). Postoperative seizure outcome was analyzed stratifying the results by tumor volumetric data and molecular markers according to 2016 WHO classification. Receiver operating characteristic (ROC) curves were computed to asses EOR, residual tumor volume, and ∆T2T1 MRI index (expressing the tumor growing pattern) corresponding to optimal seizure outcome. A total of 70.97% of patients were seizure-free 18 months after surgery. Better seizure outcome was observed in IDH1/2 mutated and 1p/19q codeleted subgroup. At multivariate analysis, age (p = 0.014), EOR (p = 0.030), ∆T2T1 MRI index (p = 0.016) resulted as independent predictors of postoperative seizure control. Optimal parameters to improve postoperative seizure outcome were EOR ≥ 85%, ∆T2T1 MRI index ≤ 18 cm 3 , residual tumor volume ≤ 15 cm 3 . This study confirms the role of EOR and tumor growing pattern on postoperative seizure outcome independently from the molecular class. Higher ∆T2T1 MRI index, representing the infiltrative component of the tumor, is associated with worse seizure outcome and strengthens the evidence of common pathogenic mechanisms underlying tumor growth and postoperative seizure outcome.to manifest with focal and focal-to-bilateral tonic-clonic seizures, and more than 50% of cases show pharmaco-resistance, which contributes negatively on quality of life [3][4][5]. Recent studies have pointed out that epileptogenesis and tumor growth in DLGG may share common pathogenic mechanisms that can influence each other, thus representing two aspects of the same disease [6]. In this context, several genetic alterations have been identified as risk factors of glioma-related epilepsy. Mutations of the gene encoding the isocitrate-dehydrogenase1 (IDH1) and 2 (IDH2) can be found in about 70%-80% of DLGG [7]. These mutations have been associated with metabolic changes that are potentially epileptogenic, in accordance with the capability of IDH-mutated glioma cells to penetrate and surround the neurons in the gray matter [8,9].Seizure outcome represents an important challenge in the daily management of DLGG patients. In particular, decision-making still varies across surgical centers given the lack of well-established and universally recognized predictors of seizure outcomes.In the last decades, numerous studies, based on the objective evaluation of the extent of resection (EOR) has been published, demonstrating that an extensive surgery leads to increased overall patient survival and decreased malignant progression [10][11][12][13][14].Although EOR has also been shown to be one of the main strongest significant predictor markers for seizure outcome [7,[15][16][17][18], its predictive role has not been completely clarified in complex predictor models for epilep...

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“…[2][3][4] Therefore, it is important to achieve better seizure control to improve the patients' quality of life. 5,6) It has been reported that approximately 30% of the cases are uncontrolled seizures, regardless of appropriate is generally used in LGG and malignant gliomas, resulted in 50% reduction in seizure frequency in 48% of patients. 17,18) From a histopathological point of view, oligodendrogliomas are more often associated with the prevalence of seizures than are astrocytomas.…”

Section: Introductionmentioning

confidence: 99%

Molecular Aberrations Associated with Seizure Control in Diffuse Astrocytic and Oligodendroglial Tumors

Suzuki

Mikuni

Sugita

et al. 2020

Neurol. Med. Chir.(Tokyo)

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Diffuse astrocytic and oligodendroglial tumors are frequently associated with symptomatic epilepsy, and predictive seizure control is important for the improvement of patient quality of life. To elucidate the factors related to drug resistance of brain tumor-associated epilepsy from a pathological perspective. From January 2012 to October 2017, 36 patients diagnosed with diffuse astrocytic or oligodendroglial tumors were included. Assessment for seizure control was performed according to the Engel classification of seizures. Patient clinical, radiological, and pathological data were stratified based on the following 16 variables: age, sex, location of tumor, existence of the preoperative seizure, extent of resection, administration of temozolomide, radiation therapy, recurrence, Karnofsky performance scale, isocitrate dehydrogenase 1, 1p/19q co-deletion, Olig2, platelet-derived growth factor receptor alpha, p53, ATRX, and Ki67. These factors were compared between the well-controlled group and drug-resistant seizure group. Twenty-seven patients experienced seizures; of these, 14 cases were well-controlled, and 13 cases were drug-resistant. Neither clinical nor radiological characteristics were significantly different between these two groups, though p53 immunodetection levels were significantly higher, and the frequency of 1p/19q co-deletion was significantly lower in the group with drug-resistant seizures than in the wellcontrolled group. In the multivariate analysis, only one item was selected according to stepwise methods, and a significant difference was observed for p53 (OR, 21.600; 95% CI, 2.135-218.579; P = 0.009). Upregulation of p53 may be a molecular mechanism underlying drug resistant epilepsy associated with diffuse astrocytic and oligodendroglial tumors.

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Genetic features of oligodendrogliomas and presence of seizures. The relationship of seizures and genetics in LGOs

Cited by 18 publications

References 0 publications

IDH1 mutation is associated with a higher preoperative seizure incidence in low-grade glioma: A systematic review and meta-analysis

IDH1 mutation is associated with a higher preoperative seizure incidence in low-grade glioma: A systematic review and meta-analysis

Predictors of Postoperative Seizure Outcome in Low Grade Glioma: From Volumetric Analysis to Molecular Stratification

Molecular Aberrations Associated with Seizure Control in Diffuse Astrocytic and Oligodendroglial Tumors

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