Genetic mapping of the chicken prolactin receptor gene: A candidate gene for the control of broodiness

Dunn, Ian; McEwan, Gordon T.A.; Okhubo, T; Sharp, P J; Paton, Ian R.; Burt, David W.

doi:10.1080/00071669888160

Cited by 25 publications

(15 citation statements)

References 3 publications

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“…PRLR mediates various physiological functions, including immunoregulation (Skwarlo-Sonta, 1992), osmoregulation (Ensor and Phillips, 1970;Morley et al, 1981;Donnen and Smith, 1982a, b;Nouwen et al, 1984;Arad et al, 1986;Roberts and Dantzler, 1992;Roberts, 1998), and the onset and maintenance of incubation behavior (Riddle et al, 1935;Saeki and Tanabe, 1955;Sharp et al, 1979) in Galliformes. Our study indicates that these two genes are located very close to each other on the chicken Z chromosome (at Zp2.2) and confirms the linkage mapping data published by Dunn et al (1998). The close proximity of these genes has also been observed on human chromosome 5 (Arden et al, 1990) and mouse chromosome 15 (Barker et al, 1992;Huppi et al, 1996), which supports the presence of evolutionary conservation of the chromosome region comprising GHR and PRLR among chicken, human, and mouse (Table 1).…”

Section: Resultssupporting

confidence: 78%

Comparative FISH mapping on Z chromosomes of chicken and Japanese quail

Suzuki

Kansaku²,

Kurosaki³

et al. 1999

Cytogenet Genome Res

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Using direct R-banding fluorescence in situ hybridization, we assigned five functional genes—growth hormone receptor (GHR), prolactin receptor (PRLR), spleen tyrosine kinase (SYK), aldolase B (ALDOB), and muscle skeletal receptor tyrosine kinase (MUSK)—to the chicken Z chromosome. SYK and MUSK were newly localized to the chicken Z chromosome in this study. GHR and PRLR were situated close to each other on the short arm of the chicken Z chromosome, as are their counterparts on human chromosome 5. SYK, MUSK, and ALDOB, which have been mapped to human chromosome 9, were localized to the long arm of the chicken Z chromosome. Thus, the present results indicate the presence of conserved synteny between the chicken Z chromosome and human chromosomes 5 and 9. Using the same method, four of the genes (GHR, PRLR, ALDOB, and MUSK) were assigned to the Japanese quail Z chromosome. The locations of these four Z-linked genes were conserved between chicken and Japanese quail. The results support the notion that the avian Z chromosome and the mammalian X chromosome did not evolve from a common ancestral linkage group.

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Section: Resultssupporting

confidence: 78%

Comparative FISH mapping on Z chromosomes of chicken and Japanese quail

Suzuki

Kansaku²,

Kurosaki³

et al. 1999

Cytogenet Genome Res

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“…Prolactin receptor (PRLR) is a single transmembrane protein that belongs to class 1 of cytokine receptor superfamily, which is also considered as a candidate gene for broodiness (Dunn, 1998). It has been proven that the expression of PRLR could induce PRL expression and modulates PRL inducible signal transmitting (Marone et al., 1997; Vleck et al., 2000), and in some instance, PRLR participated in incubation.…”

Section: Discussionmentioning

confidence: 99%

Physiological and hormonal aspects in female domestic pigeons (Columba livia) associated with breeding stage and experience

Dong

Jia

Zou

2012

Animal Physiology Nutrition

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The present study examined the changes in serum biochemical values, hormone profiles and ovary prolactin receptor (PRLR) gene expression occurring in female domestic pigeons (Columba livia) under different breeding status and experience. The egg-laying pigeons had lower calcium, total protein, albumin, prolactin levels and higher oestrogen levels than those of incubating birds (p < 0.05). First-time breeders had higher (p < 0.05) progesterone levels and lower (p < 0.05) prolactin levels than that of experienced ones. The levels of oestrogen and follicle-stimulating hormone (FSH) increased with age (p < 0.05). The very old birds showed a pronounced increase (p < 0.05) in PRL, FSH and progesterone and a little decrease in oestrogen. Serum prolactin level was not correlated with the ovary PRLR mRNA expression pattern among all the pigeons. Results showed that serum physiological profile of female pigeons was correlated with breeding status, whereas reproductive hormone levels were correlated with advancing breeding experience. It was concluded that female pigeons had a good ability of recovering from nutrient loss after each breeding attempts, and the degradation of reproductive performance might be attributed to changes in the endocrine system.

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“…Prolactin gene in chicken (cPRL) specifically on the promoter region is a candidate gene for brooding behaviour (Shimada et al, 1991;Dunn et al, 1998), and egg production . cPRL promoter gene is an important part that responsible in the expression or the function of cPRL.…”

Section: Resultsmentioning

confidence: 99%

“…In birds, cPRL is coded by a gene located on chromosome 2 (Miao et al, 1999;Au and Leung, 2000), and become a candidate gene for brooding trait (Shimada et al, 1991;Dunn et al, 1998) and egg production . Chicken prolactin gene is 9.536 bp in size, consisted of 3 parts, promoter-1, promoter-2 and promoter-3 with 330 bp, 287 bp, and 314 bp, respectively (Kansaku, 2000).…”

Section: Introductionmentioning

confidence: 99%

A 24-bp Indel (Insertion-Deletion) Polymorphism in Promoter Prolactin Gene

Lumatauw

Mu’in

2016

JAP

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Abstract. Prolactin in chicken (cPRL) is a polypeptide hormone that plays a crucial role in incubation and brooding behavior. This hormone is coded by a gene located at chromosome 2. The objective of this study was to investigate 24-bp indel polymorphism in promoter prolactin gene of Papua local chickens. A number of 60 DNA samples came from 60 Papua local chickens (25 males and 35 females) were used in this study. PCR (Polymerase Chain Reaction) method with a pair of specific primer was applied and a specific DNA fragment with 130 and/or 154 bp contained 24-bp indel was successfully amplified. Results of electrophoresis run on 1.5 % agarose gel showed three genotypes: II, ID and DD with the frequency of 6,7%, 48.3% and 45% respectively. The frequency of I allele and D allele was 0.69 and 0.31, respectively. Results indicated that the I allele frequency was medium in Papua local chickens population. Results therefore suggest that incubation behavior in hen population of Papua local chickens is easy to eliminate by increasing the I allele frequency in the population.Key words: 24-bp Indel, Papua local chicken, polymorphism, promoter prolactin gene.

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Genetic mapping of the chicken prolactin receptor gene: A candidate gene for the control of broodiness

Cited by 25 publications

References 3 publications

Comparative FISH mapping on Z chromosomes of chicken and Japanese quail

Comparative FISH mapping on Z chromosomes of chicken and Japanese quail

Physiological and hormonal aspects in female domestic pigeons (Columba livia) associated with breeding stage and experience

A 24-bp Indel (Insertion-Deletion) Polymorphism in Promoter Prolactin Gene

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