Genetic parameters of wound healing in patients with neuropatic diabetic foot ulcers

Zaitseva, Ekaterina L.; Tokmakova, Alla Y.; Voronkova, I A; Petrov, V. M.; Tiulpakov, Anatoly; Shestakova, Marina V.

doi:10.14341/dm9291

Cited by 5 publications

(9 citation statements)

References 13 publications

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“…We found 12 RCTs 24,[38][39][40][41][42][43][44][45][46][47][48] comprising 986 participants comparing collagen/alginate dressings to a standard of care and which fulfilled our inclusion criteria. None of the studies were double-blind; three 38,39,41 were outcome blind, one 44 patient blind, and one had uncertain blinding.…”

Section: Collagen or Alginatesmentioning

confidence: 99%

“…Eleven studies reported on reduction in ulcer area. 24,[39][40][41][42][43][44][45][46][47][48] Only two 41,46 reported this being significantly improved in the intervention arm compared to a control dressing. The former was performed in a primarily inpatient population, and, as outcomes were assessed at only 9 days, generalisability is limited.…”

Section: Outcome: Reduction In Ulcer Areamentioning

confidence: 99%

“…We included 19 studies comparing negative-pressure wound therapy to standard of care, 46,166,[255][256][257][258][259][260][261][262][263][264][265][266][267][268][269][270][271] which fitted our inclusion criteria, the majority of which were in post-surgical diabetes-related foot wounds. Two were in a mixed population comprising post-surgical and non-surgical wounds, 255,267 and only one in nonsurgical wounds alone.…”

Section: Intervention 8: Negative Pressure Wound Therapymentioning

confidence: 99%

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Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: A systematic review

Chen,

Vilorio,

Dhatariya

et al. 2024

Diabetes Metabolism Res

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BackgroundIt is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high‐quality evidence and cost‐effectiveness. In previous years, the systematic review accompanying guidelines published by the International Working Group of the Diabetic Foot performed 4‐yearly updates of previous searches, including trials of prospective, cross‐sectional and case‐control design.AimsDue to a need to re‐evaluate older studies against newer standards of reporting and assessment of risk of bias, we performed a whole new search from conception, but limiting studies to randomised control trials only.Materials and MethodsFor this systematic review, we searched PubMed, Scopus and Web of Science databases for published studies on randomised control trials of interventions to enhance healing of diabetes‐related foot ulcers. We only included trials comparing interventions to standard of care. Two independent reviewers selected articles for inclusion and assessed relevant outcomes as well as methodological quality.ResultsThe literature search identified 22,250 articles, of which 262 were selected for full text review across 10 categories of interventions. Overall, the certainty of evidence for a majority of wound healing interventions was low or very low, with moderate evidence existing for two interventions (sucrose‐octasulfate and leucocyte, platelet and fibrin patch) and low quality evidence for a further four (hyperbaric oxygen, topical oxygen, placental derived products and negative pressure wound therapy). The majority of interventions had insufficient evidence.ConclusionOverall, the evidence to support any other intervention to enhance wound healing is lacking and further high‐quality randomised control trials are encouraged.

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Section: Collagen or Alginatesmentioning

confidence: 99%

Section: Outcome: Reduction In Ulcer Areamentioning

confidence: 99%

Section: Intervention 8: Negative Pressure Wound Therapymentioning

confidence: 99%

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Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: A systematic review

Chen,

Vilorio,

Dhatariya

et al. 2024

Diabetes Metabolism Res

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“…All were at moderate or high risk of bias and most were non-blinded. Four studies compared collagen only with moist wound therapy, 45,47,48,52 one study 46 used collagen-alginate, one used a calcium alginate, 51 one compared a collagen/oxidised regenerated cellulose/silver treatment with foam, 29 one the same collagen/oxidised regenerated cellulose but without silver, 54 one compared collagen with negative pressure wound therapy, 50 one compared collagen with gauze or hydrocolloid dressings 49 , and another two 51,53 alginate alone as the intervention. Of the 12 studies, nine of them 29,[45][46][47]49,[51][52][53][54] did not report a difference in wound healing or reduction in ulcer area at the end of study duration.…”

Section: Honey or Bee Productsmentioning

confidence: 99%

“…241 Overall, the balance of effects was not thought to favour either Rationale: We identified 19 studies which fulfiled our inclusion criteria. 50,152,[244][245][246][247][248][249][250][251][252][253][254][255][256][257][258][259][260] All studies were thought to be at moderate to high risk of bias.…”

Section: Rationalementioning

confidence: 99%

Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update)

Chen,

Vilorio,

Dhatariya

et al. 2023

Diabetes Metabolism Res

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AimsPrinciples of wound management, including debridement, wound bed preparation, and newer technologies involving alternation of wound physiology to facilitate healing, are of utmost importance when attempting to heal a chronic diabetes‐related foot ulcer. However, the rising incidence and costs of diabetes‐related foot ulcer management necessitate that interventions to enhance wound healing of chronic diabetes‐related foot ulcers are supported by high‐quality evidence of efficacy and cost effectiveness when used in conjunction with established aspects of gold‐standard multidisciplinary care. This is the 2023 International Working Group on the Diabetic Foot (IWGDF) evidence‐based guideline on wound healing interventions to promote healing of foot ulcers in persons with diabetes. It serves as an update of the 2019 IWGDF guideline.Materials and MethodsWe followed the GRADE approach by devising clinical questions and important outcomes in the Patient‐Intervention‐Control‐Outcome (PICO) format, undertaking a systematic review, developing summary of judgements tables, and writing recommendations and rationale for each question. Each recommendation is based on the evidence found in the systematic review and, using the GRADE summary of judgement items, including desirable and undesirable effects, certainty of evidence, patient values, resources required, cost effectiveness, equity, feasibility, and acceptability, we formulated recommendations that were agreed by the authors and reviewed by independent experts and stakeholders.ResultsFrom the results of the systematic review and evidence‐to‐decision making process, we were able to make 29 separate recommendations. We made a number of conditional supportive recommendations for the use of interventions to improve healing of foot ulcers in people with diabetes. These include the use of sucrose octasulfate dressings, the use of negative pressure wound therapies for post‐operative wounds, the use of placental‐derived products, the use of the autologous leucocyte/platelet/fibrin patch, the use of topical oxygen therapy, and the use of hyperbaric oxygen. Although in all cases it was stressed that these should be used where best standard of care was not able to heal the wound alone and where resources were available for the interventions.ConclusionsThese wound healing recommendations should support improved outcomes for people with diabetes and ulcers of the foot, and we hope that widescale implementation will follow. However, although the certainty of much of the evidence on which to base the recommendations is improving, it remains poor overall. We encourage not more, but better quality trials including those with a health economic analysis, into this area.

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Bioreactors for Vocal Fold Tissue Engineering

Martins

Biehl

Sze

et al. 2022

Tissue Engineering Part B: Reviews

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Genetic parameters of wound healing in patients with neuropatic diabetic foot ulcers

Cited by 5 publications

References 13 publications

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: A systematic review

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: A systematic review

Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update)

Bioreactors for Vocal Fold Tissue Engineering

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