Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis

Shibata, Tomoyuki; Tahara, Tomomitsu; Hirata, Ichiro; Arisawa, Tomiyasu

doi:10.1016/j.humimm.2009.04.030

Cited by 119 publications

(98 citation statements)

References 30 publications

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“…The genotype frequencies of 197A/A, 197A/G and 197G/G were 16, 46 and 38% in recipients and 14, 51 and 36% in donors. These were similar to previous reports 38,48 in Japanese populations (15,52 and 33%, respectively) and Caucasian populations (13, 48 and 39%, respectively), and were in accord with the Hardy-Weinberg equilibrium (P ¼ 0.91).…”

Section: Discovery Studysupporting

confidence: 92%

A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

Espinoza

Takami

Onizuka

et al. 2011

Bone Marrow Transplant

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IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLAmatched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP). In the discovery study, the presence of a 197A genotype in the recipient resulted in a higher incidence of grades II-IV acute GVHD (hazard ratio (HR), 1.87; 95% confidence interval (CI), 1.23-2.85; P ¼ 0.004). The donor IL-17A genotype did not significantly influence the transplant outcomes. The validation study showed a trend toward an association of the recipient 197A genotype with an increased risk of grades III-IV acute GVHD (HR, 5.84; 95% CI,; P ¼ 0.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95% CI, 1.29-11.59; P ¼ 0.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD.

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Section: Discovery Studysupporting

confidence: 92%

A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

Espinoza

Takami

Onizuka

et al. 2011

Bone Marrow Transplant

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“…Important roles of both IL-17 and MIF in the inflammatory response to H. pylori infection have been demonstrated (25,26). Recently, we have also shown the potential roles of IL-17A, -17F and MIF polymorphisms in the gastric inflammation (27,28) and carcinogenesis (29,30).…”

Section: Introductionmentioning

confidence: 85%

Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa

et al. 2009

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Abstract. CpG island hyper-methylation (CIHM) is one of the major events in the gastric carcinogenesis and also occurs in non-neoplastic gastric mucosa. IL-17A, -17F and MIF have a crucial role in the gastric inflammationand carcinogenesis. The CIHM status in the non-cancerous gastric mucosa, in relation to IL-17A (-197G>A, rs2275913), -17F (7488T>C, rs763780) and MIF (-173G>C and -794 tetranucleotide repeats) polymorphisms was investigated. Gastric mucosa samples were obtained from 121 cancer free subjects. CIHM of p14, p16, DAP-kinase and CDH1 genes were determined by methylation-specific polymerase chain reaction (MSP). CIHM high was defined as three or all CpG islands methylated. We employed the PCR-SSCP (multiplex PCR for IL-17A and -17F) method to detect the gene polymorphisms. No association were found between CIHM status and L-17A (-197G>A), IL-17F (7488T>C) and MIF (-173G>C) polymorphisms. MIF 5-CATT repeat carrier (5/5+5/6+5/7) held a significantly higher risk of CIHM of DAP-kinase (OR=2.33, 95% CI=1.07-5.09, p=0.03) and CIHM high (OR=3.63, 95% CI=1.31-10.08, p=0.01). Weak association was also found between the same genotype and increased risk of CIHM of p16 (OR=2.45, 95% CI=0. 90-6.68, p=0.08) and CDH1 (OR=2.23, 95% CI=0.94-5.32, p=0.07). 6-CATT repeat carrier (5/6+6/6+6/7) was significantly associated with reduced risk of CIHM of p16 (OR=0.31, 95% CI=0.11-0.90, p=0.03), CDH1 (OR=0.40, 95% CI=0.17-0.98, p=0.045), DAP-kinase (OR=0.37, 95% CI=0.17-0.83, p=0.02) and CIHM high (OR=0.25, 95% CI=0.09-0.74, p=0.01). -7-CATT repeat carrier (6/7+7/7) was weakly associated with reduced risk of CIHM of p16 (OR=0.34, 95% CI=0.10-1.13, p=0.08), DAP-kinase (OR=0.43, 95% CI=0.17-1.06, p=0.07) and CIHM high (OR=0.38, 95% CI=0.12-1.20, p=0.098). The present results provided the first evidence that the genetic polymorphisms MIF polymorphism is associated with CIHM status in the human gastric mucosa. Genetic polymorphisms of MIF-794-CATT repeat may be involved in methylation related carcinogenesis in the stomach.

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“…IL-17 was found to stimulate fibroblasts to produce IL-6, IL-11, IL-8 (Mo et al, 2001;Ran et al, 2012). Majority of analyzes about genetic polymorphism of IL-17 were focus on a range of cancers, including breast cancer, gastric cancer and cervical cancer (Quan et al, 2005;Shibata et al, 2009;Shu et al, 2010;Wang et al, 2012). But no analysis about the relationship between IL-17 polymorphisms and silicosis has been reported.…”

Section: Discussionmentioning

confidence: 99%

Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

Chen

Fan²,

Jin³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis

Cited by 119 publications

References 30 publications

A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa

Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

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