Genetic polymorphisms in very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China

Li, Jing; Guo, Chenghao; Yan, Mengdan; Niu, Fanglin; Chen, Peng; Li, Bin; Jin, Tianbo

doi:10.1097/md.0000000000010559

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Therefore, the study of differences in pharmacogenomics among different populations can provide valuable theoretical basis for individualized drug treatment based on different populations. At present, there are studies on population genetics of genes related to drug-metabolism enzymes in ethnic minorities in Yunnan Province (Zhuang population [4] and Yi population [5] ), Tibet Autonomous Region (Lhoba population, [6] Deng population, [7] Sherpa population, [8] and Tibetan population [9] ), Xinjiang Uygur Autonomous Region (Uygur population, [10] Tajik ethnic population, [11] and Kyrgyz population), [12] and Guizhou province (Miao people [13] ). The Lisu originates from the ancient Diqiang family and has the origin relationship with the Yi people.…”

Section: Introductionmentioning

confidence: 99%

Population genetic difference of pharmacogenomic VIP gene variants in the Lisu population from Yunnan Province

et al. 2018

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Individual differences in drug clinical response are related to pharmacogenomics. The genetic variation of drug-metabolizing enzymes, drug receptors, and their downstream protein genes is the main factor causing individual differences in drug response. The genetic backgrounds among different ethnic groups are quite different. In this study, we aimed to detect the distribution difference of genotype frequency in very important pharmacogenetic (VIP) gene variants in the Lisu.Using the chi-squared test, we compared the genotype frequencies of the VIP variants in 105 Lisu people with those in 26 populations from the 1000 Genome project separately. Bonferroni's multiple adjustment was also conducted (P < .05/(26∗49)). Moreover, Arlequin v3.5 and Structure v2.3.4 software were used to analyze the genetic distance and genetic structure.There were 9, 9, 11, 12, 11, 11, 9, 17, 13, 13, 16, 5, 3, 5, 3, 4, 17, 14, 16, 17, 16, 10, 13, 12, 10, and 9 single nucleotide polymorphisms that differed in frequency distribution, when Lisu people compared with the 26 populations separately. Only CYP2E1 rs2070676 was different in the Lisu population compared with the 26 groups from the 1000 Genome project. PTGS2 rs5275 and CYP2D6 rs1065852 were different in the Lisu population compared with most of the populations. Additionally, genetic backgrounds of Lisu and Han Chinese in Beijing were closest according to the lowest F-statistics value and resemblance in genetic structures.Our results complete the information of the Lisu population in pharmacogenomics database.

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Section: Introductionmentioning

confidence: 99%

Population genetic difference of pharmacogenomic VIP gene variants in the Lisu population from Yunnan Province

et al. 2018

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“…Shi et al researched the genetic polymorphism of VIP variation in the pharmacogenomic of the Himalayan Deng people in southeast Tibet (Shi et al, ). Li et al investigated the genetic polymorphism of very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China (Li et al, ). However, no report has addressed studies of pharmacogenomics information regarding the Bai nationality.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms analysis of pharmacogenomic VIP variants in Bai ethnic group from China

Chen

Ding²,

Cheng

et al. 2019

Molec Gen & Gen Med

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Background The pharmacogenomics study has been widely used for the study of very important pharmacogenetic (VIP) variants among different ethnic groups. However, there is little known about the pharmacogenomics information regarding Bai family. Our study aimed to screen the polymorphism of the VIP gene in Bai nationality. Methods We genotyped 81 VIP variants (selected from the PharmGKB database) in the Bai population and then compared them to the other 11 major HapMap populations by chi‐square test, structure and F‐statistics (Fst) analysis. Results Our results indicated that rs20417 (PTGS2), rs4148323 (UGT1A), and rs1131596 (SLC19A1) were most different in Bai compared with most of the 11 populations from the HapMap data set. Furthermore, population structure and F‐statistics (Fst) analysis also demonstrated that the Bai population has the closest genetic relationship with Han Chinese in Beijing, China (CHB), followed by Japanese in Tokyo, Japan (JPT), and the farthest population from the Yoruba in Ibadan, Nigeria (YRI). Conclusions Our study not only presented the genotype frequency difference between the selected population of the Bai population and the other 11 populations, but also showed that the Bai population is most similar to the CHB populations, followed by JPT. These findings would contribute to the development of individualized medicine for the Bai population.

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“…The Han and Zhuang ethnic groups make up the largest proportion of the population of the Guangxi Zhuang Autonomous Region of China (62 and 32%, respectively). Previously, a large number of studies have focused on diseases in these two groups within the population with several genetic differences, including the prevalence of genes linked to hyperlipidemia and 3'APOB-VNTR polymorphisms, and other differences, including the presence of many pharmacogenetic variants and drug detoxification mechanisms, having been identified (5)(6)(7). In this light, the present study was performed to explore diagnostic biomarkers of coronary artery stenosis in patients of the ethnic Zhuang group with CHD and to validate potential correlations between the expression levels of TLR2/4 in the circulatory system.…”

Section: Introductionmentioning

confidence: 99%

Correlation between coronary stenosis and Toll‑like receptors 2 and 4 levels in Chinese Zhuang patients with coronary heart disease

et al. 2019

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The present study attempted to determine the correlation of the degree of coronary artery stenosis and Tolllike receptor 2/4 (TLR2/4) levels in Chinese Zhuang patients with coronary heart disease (CHD). A total of 466 Chinese patients from the Zhuang Ethnic population diagnosed with CHD at the , together with 102 control patients, were recruited for the present study. The patients with CHD were divided into three groups depending on the number of diseased arteries. The patients with CHD were also classified according to their Gensini scores. Blood liver and renal function parameters, as well as blood sugar and lipid levels were measured. ELISA was used for TLR2/4 measurements. There were no significant differences with gender, age and body mass index between the CHD and control groups. The levels of TLR2/4 in the peripheral blood of the control and CHD groups were 2.34±0.85/5.08±2.41 and 5.22±3.16/9.33±4.92 ng/ml, respectively, and the differences were significant (P<0.001). Analysis of the three subgroups of vessel disease indicated that the expression of TLR2/4 was progressively higher with the increase in the number of affected vessels (P<0.01). There were also significant differences between the mild, moderate and severe stenosis groups (P<0.01). A positive linear correlation between TLR2/4 and the Gensini coronary artery score was identified (r=0.508 and 0.346, respectively; P<0.0001). In conclusion, the present study determined a positive correlation between the degree of coronary artery stenosis and the expression level of TLR2/4 in the serum of Chinese Zhuang patients with CHD. Serum TLR2/4 may be used to predict the severity of CHD.

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Genetic polymorphisms in very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China

Cited by 3 publications

References 37 publications

Population genetic difference of pharmacogenomic VIP gene variants in the Lisu population from Yunnan Province

Population genetic difference of pharmacogenomic VIP gene variants in the Lisu population from Yunnan Province

Genetic polymorphisms analysis of pharmacogenomic VIP variants in Bai ethnic group from China

Correlation between coronary stenosis and Toll‑like receptors 2 and 4 levels in Chinese Zhuang patients with coronary heart disease

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