Genetic Risk Factors in Young Patients With Ischemic Colitis

Clinical Characteristics of Young-Onset Ischemic Colitis

“…Further prospective data accumulation of young IC patients might clarify the relationship between these factors and IC pathogenesis. Additionally, polymorphisms of the coagulation factor V and plasminogen activator inhibitor genes are thought to be predisposing causes of young IC in Europe [21]. Thus, it may be of value to examine such gene polymorphisms in young Japanese IC patients as well.…”

“…Constipation [12], history of abdominal operation [12], irritable bowel syndrome [13], vasculitis [14], contraceptive pill use [15,16], cocaine [17] and methamphetamine use [18], sickle cell anemia [19], long-distance running [20], and polymorphisms in the coagulation factor V and plasminogen activator inhibitor genes [21] are thought to be predisposing factors for young-onset IC. However, such risk factors have not been fully investigated in the Japanese population.…”

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

“…Vasospasm of the colonic vessels is another mechanism for the development of ischemic colitis, either due to systemic hypoperfusion, which shunts the blood from the intestine to the brain and other viable organs, or due to the exposure to vasoconstrictor drugs and substances that have direct or indirect effects on the splanchnic circulation, such as phenylephrine and cocaine . A third pathophysiological mechanism is thromboembolism due to either hypercoagulable states, including gene mutations and coagulation factor deficiencies, or cardiac emboli . According to the previous studies, 28–72% of the patients with ischemic colitis have one or more coagulation disorders .…”

Ischemic colitis: Clinical practice in diagnosis and treatment

“…Vasculitides, estrogens, cocaine and methamphetamine use, psychotropic drugs, sickle cell disease, long-distance running and heritable disorders of coagulation should be considered [19][20][21][22][23][24] . In a recent study [25] , the frequency of the 506 Q allele of the factor V (FV) 506 RQ (Leiden) mutation and the mutant 4G allele of plasminogen activator inhibitor (PAI) polymorphism were found to be significantly higher in young patients with IC compared with healthy controls.…”